Khosrotehrani Group - Research

Our current research projects cover three main clinical questions. Each question is addressed in the laboratory but also in clinical research

Skin wound healing

• Modulation of wound inflammation and microbiome (NHMRC)
• Molecular drivers of wound vascularisation and endovascular progenitors (ARC Discovery)
• Scarring and endothelial to mesenchymal transition in wounds and scleroderma (DOD)

Clinical translation

• IxeHeal trial: blocking IL17 to accelerate healing of chronic venous ulcers

Keratinocyte cancers​

• Epidermal clonal behaviour upon Ultraviolet irradiation and carcinogenesis (NHMRC)
• Immune responses to basal cell carcinoma

Clinical translation

• Chemo-immunoprevention of keratinocyte cancers in solid organ transplant recipients
• Laser ablation to reduce mutational burden in photodamaged skin (clinical trial)(NHMRC)
• Anti-proliferative agents to reduce skin cancer in organ transplant recipients (Randomized, double blind clinical trial)(PA-Research Foundation)
• VMAT surface radiation to prevent skin cancer (randomized clinical trial) (Genesis Care)

Melanoma

• Melanoma vascularisation through endovascular progenitors and metastasis (NHMRC)

Clinical translation

• Phase 0 study of Sox18 inhibition in adjuvant setting (Randomized clinical trial)(NHMRC)
• Vascular and immune biomarkers of disease progression in melanoma (Cancer Council)

Student projects

• Modulation of wound inflammation and microbiome