Camilla graduated from the Ji Lin University (China) in 2003 with a B.E. in Bio-pharmaceutical Engineering. In 2007, she received her Master degree in Medical Biotechnology studies from Flinders University of South Australia. In 2009 she received an ANU PhD scholarship and began her PhD study at The John Curtin School of Medical Research, Australian National University. Her work was to evaluate the adjuvant activity of interferon epsilon (IFN-ε) and Toll-like receptor 9 (TLR9) to enhance HIV-specific mucosal Immunity. After completed her PhD, Cami joined the Professor John Upham’s laboratory at the Lung and Allergy Research Centre, investigating how human rhinoviruses affect innate immune response specifically in plasmacytoid dendritic cells (pDC) regulated, RV-stimulated type I interferon (IFN-I) response in human. She has also been involving in IVC research project, using influenza vaccination to understand and improve anti-viral immunity in Chronic Obstructive Pulmonary Disease (COPD). Her current project (AVIDA) is to investigate anti-viral immune dysfunction in severe asthma varies across inflammatory phenotypes.
Journal Articles
Snape, Natale, Anderson, Gary P., Irving, Louis B., Jarnicki, Andrew G., Hurt, Aeron C., Collins, Tina, Xi, Yang and Upham, John W. (2022). Vaccine strain affects seroconversion after influenza vaccination in COPD patients and healthy older people. npj Vaccines, 7 (1) 8, 8. doi: 10.1038/s41541-021-00422-4
Murray, Liisa M., Thillaiyampalam, Gayathri, Xi, Yang, Cristino, Alexandre S. and Upham, John W. (2021). Whole transcriptome analysis of high and low IFN‐α producers reveals differential response patterns following rhinovirus stimulation. Clinical and Translational Immunology, 10 (11) e1356, 1-17. doi: 10.1002/cti2.1356
van der Heide, Saskia L., Xi, Yang and Upham, John W. (2020). Natural killer cells and host defense against human rhinoviruses is partially dependent on type I IFN signaling. Frontiers in Cellular and Infection Microbiology, 10 510619, 1-12. doi: 10.3389/fcimb.2020.510619
Xi, Yang and Upham, John W. (2020). Plasmacytoid dendritic cells and asthma: a review of current knowledge. Expert Review of Respiratory Medicine, 14 (11), 1095-`1106. doi: 10.1080/17476348.2020.1803741
Murray, Liisa, Xi, Yang and Upham, John W. (2019). CLEC4C gene expression can be used to quantify circulating plasmacytoid dendritic cells. Journal of Immunological Methods, 464, 126-130. doi: 10.1016/j.jim.2018.11.001
Jurak, Lisa M., Xi, Yang, Landgraf, Megan, Carroll, Melanie L., Murray, Liisa and Upham, John W. (2018). Interleukin 33 selectively augments rhinovirus-induced type 2 immune responses in asthmatic but not healthy people. Frontiers in Immunology, 9 (AUG) 1895, 1895. doi: 10.3389/fimmu.2018.01895
Chen, Alice C. -H., Tran, Hai B., Xi, Yang, Yerkovich, Stephanie T., Baines, Katherine J., Pizzutto, Susan J., Carroll, Melanie, Robertson, Avril A. B., Cooper, Matthew A., Schroder, Kate, Simpson, Jodie L., Gibson, Peter G., Hodge, Greg, Masters, Ian B., Buntain, Helen M., Petsky, Helen L., Prime, Samantha J., Chang, Anne B., Hodge, Sandra and Upham, John W. (2018). Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research, 4 (1) 00130-2017, 00130-2017. doi: 10.1183/23120541.00130-2017
Xi, Yang, Troy, Niamh M., Anderson, Denise, Pena, Olga M., Lynch, Jason P., Phipps, Simon, Bosco, Anthony and Upham, John W. (2017). Critical role of plasmacytoid dendritic cells in regulating gene expression and innate immune responses to human rhinovirus-16. Frontiers in Immunology, 8 (OCT) 1351, 1351. doi: 10.3389/fimmu.2017.01351
Chen, Alice C.-H., Xi, Yang, Carroll, Melanie, Petsky, Helen L., Gardiner, Samantha J., Pizzutto, Susan J., Yerkovich, Stephanie T., Baines, Katherine J., Gibson, Peter G., Hodge, Sandra, Masters, Ian B., Buntain, Helen M., Chang, Anne B. and Upham, John W. (2017). Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β. ERJ Open Research, 3 (4) 00025-2017, 00025-2017. doi: 10.1183/23120541.00025-2017
Upham, John W. and Xi, Yang (2017). Dendritic cells in human lung disease: recent advances. Chest, 151 (3), 668-673. doi: 10.1016/j.chest.2016.09.030
Xi, Yang, Finlayson, Arvid, White, Oliva J., Carroll, Melanie L. and Upham, John W. (2015). Rhinovirus stimulated IFN-α production: how important are plasmacytoid DCs, monocytes and endosomal pH?. Clinical and Translational Immunology, 4 (10) e46, e46. doi: 10.1038/cti.2015.27
Wong, K.J, Timbrell, Victoria L., Xi, Y, Upham, J.W, Collins, A.M and Davies, J.M (2015). IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis. Allergy: European Journal of Allergy and Clinical Immunology, 70 (4), 420-428. doi: 10.1111/all.12563
Wijesundara, Danushka Kumara, Xi, Yang and Ranasinghe, Charani (2014). Unraveling the convoluted biological roles of type I interferons in infection and immunity: a way forward for therapeutics and vaccine design. Frontiers in Immunology, 5 (AUG) Article 412, 412. doi: 10.3389/fimmu.2014.00412
Xi, Yang, Day, Stephanie L., Jackson, Ronald J. and Ranasinghe, Charani (2012). Role of novel type I interferon epsilon in viral infection and mucosal immunity. Mucosal Immunology, 5 (6), 610-622. doi: 10.1038/mi.2012.35
Xi, Y, Day, SL, Jackson, RJ and Ranasinghe, C (2012). Role of novel type I interferon epsilon in mucosal immunity. Retrovirology, 9 (S2) P192, 192-192. doi: 10.1186/1742-4690-9-s2-p192
Conference Papers
Gupta, S., Fricker, M., Xi, Y., Grainge, C., Upham, J. and Simpson, J. (2020). FC Gamma receptor (FCGR) I expression is increased in severe asthma particularly in participants with non-eosinophilic airway inflammation. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, QLD Australia, 27-31 March 2020. Hoboken, NJ USA: Wiley.
Upham, J., Murray, L. and Xi, Y. (2020). Factors associated with respiratory infection frequency in healthy and asthmatic adults differ between women and men. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, QLD Australia, 27-31 March 2020. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.
Upham, J., Jurak, L. and Xi, Y. (2018). IL-33 and rhinovirus effects on IL-33 receptor expression in asthma. The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, ,, Adelaide, Australia, 23–27 March 2018. Hoboken, NJ United States: Wiley.
Upham, J. W., Jurak, L. and Xi, Y. (2018). Differential effects of IL-33 on anti-viral immune responses in asthmatic and healthy individuals. International Conference of the American Thoracic Society, San Diego, CA, United States, 18-23 May, 2018. New York, NY, United States: American Thoracic Society.
Upham, John, Jurak, Lisa and Xi, Yang (2017). IL-33 augments rhinovirus-induced type 2 immune responses in asthma via selective upregulation of one chain of the IL-33 receptor. ERS International Congress 2017, Milan, Italy, 9-13 September 2017. Lausanne, Switzerland: European Respiratory Society. doi: 10.1183/1393003.congress-2017.pa567
Upham, J. W., Murray, L., Xi, Y., Revez, J. and Ferreira, M. (2017). Determinants Of Rhinovirus And Nucleic Acid Induced Cytokine Production In A Large Group Of Healthy And Asthmatic Individuals. International Conference of the American-Thoracic-Society (ATS), Washington Afghanistan, 19-24 May 2017. New York, NY United States: American Thoracic Society.
Murray, Liisa, Xi, Yang, Revez, Joana A., Ferreira, Manuel A. and Upham, John W. (2017). Determinants of Rhinovirus and Nucleic Acid Induced Cytokine Production in a Large Cohort. The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Canberra, Australia, 24–28 March 2017. Richmond, VIC Australia: Wiley.
Upham, John, Xi, Camilla, Pena, Olga and Bosco, Anthony (2016). LSC Abstract - Punching above their weight: Plasmacytoid dendritic cells play a critical role in regulating rhinovirus induced gene expression pathways. ERS International Congress 2016, London, United Kingdom, 3-7 September, 2016. Lausanne, Switzerland: European Respiratory Society. doi: 10.1183/13993003.congress-2016.PP236
Xi, Y., Bosco, A. and Upham, J. W. (2016). Critical role of pDC in regulating gene expression and innate immune responses to human rhinovirus. International Congress of Immunology (ICI), Melbourne Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Xi, Yang , Anthony, Bosco and Upham, John (2016). Critical Role of pDC in regulating gene expression and innate immune responses to human rhinovirus. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016.
Upham, J., Xi, C., Pena, O. and Bosco, A. (2016). Plasmacytoid Dendritic Cells Play A Critical Role In Regulating Gene Expression Patterns Induced By Human Rhinoviruses. International Conference of the American-Thoracic-Society (ATS), San Francisco Ca United States, 13-18 May 2016. New York, NY United States: American Thoracic Society.
Upham, J., Landgraf, M., Xi, Y. and Carroll, M. (2016). Il-33 Augments Rhinovirus-Induced Type 2 Immune Responses in Subjects with Asthma, But Not in Healthy Individuals. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1-6 April 2016. HOBOKEN: WILEY-BLACKWELL.
Upham, J., Xi, Y., Pena, O. and Bosco, A. (2016). Plasmacytoid Dendritic Cells Play a Critical Role in Regulating Rhinovirus Induced Gene Expression Pathways. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, 1-6 April 2016. HOBOKEN: European Respiratory Society. doi: 10.1183/13993003.congress-2016.pp236
Upham, John, Landgraf, Megan and Xi, Camilla (2015). Interleukin-33 augments rhinovirus-induced type 2 immune responses in people with asthma, but not in healthy donors. Lausanne, Switzerland: European Respiratory Society. doi: 10.1183/13993003.congress-2015.pa4369