Steptoe Group - Research projects
Our current research projects are focussed around gene therapy approaches to immunotherapy using genetically-engineered hematopoietic stem cells. We are using advanced models employing human cells that allow us to investigate whether immune responses that underlie type 1 diabetes in humans can be turned off.
We are exploring protocols for safe and simple gene transfer that facilitate translation of gene therapy for immunotherapy to patients.
We also are investigating novel immunthepaeutics to bolster immune responses against tumours.
Student projects
- Cellular and molecular pathways of T-cell tolerance
- Prevention and reversal of autoimmune diabetes
- Novel methods of gene delivery for tolerance
- Immunotherapy of allergies and anaphylaxis