Professor Antje Blumenthal
Professor
Frazer Institute
Affiliate Associate Professor
Institute for Molecular Bioscience
Centre Director of Australian Infectious Diseases Research Centre
Australian Infectious Diseases Research Centre
+61 7 344 36984
Professor Antje Blumenthal leads the Infection and inflammation group.
Research projects
- Innate immune recognition of Mycobacterium tuberculosis and other pathogens
- Molecular mechanisms of macrophage functions
- Regulators of immune responses during infection and inflammation
- Discovery of novel anti-microbials
- Enhancing host defence mechanisms in severe bacterial infections
Researcher biography
Professor Antje Blumenthal combines her expertise in immunology and microbiology to lead research on molecular mechanisms that control immune responses to infection, alongside more recently developed research on new antimicrobials. The overall goal of her research is to improve our ability to treat severe bacterial infections as part of the global efforts to overcome the threat posed by antibiotic-resistant bacteria. Prof Blumenthal graduated with a major in Microbiology from the Christian-Albrechts-University in Kiel, Germany, pursued PhD research in Immunology at the Leibniz Research Center for Medicine and Biosciences Borstel, Germany, and undertook postdoctoral training at Weill Cornell Medical College, New York, USA. She joined The University of Queensland Diamantina Institute in 2010 where she leads the Infection & Inflammation Group, fostering cross-disciplinary collaborations with immunologists, microbiologists, chemists, clinical research teams and industry partners. Her research is enabled by major funding from international and national agencies, and has been recognised internationally and nationally by prestigious awards, speaking invitations at eminent conferences and institutions, invitations to peer-review for esteemed journals and funding agencies. Prof Blumenthal is an enthusiastic undergraduate teacher and research student advisor. She is proactive in advancing the careers of junior scientists, leads the development and implementation of initiatives that promote equity, diversity and inclusion in science, and a positive workplace culture. Through leadership roles within the University and professional societies as well as editorial roles for international journals, Prof Blumenthal actively contributes to the scientific community.
Journal Articles
Walsham, James, Hammond, Naomi, Blumenthal, Antje, Cohen, Jeremy, Myburgh, John, Finfer, Simon, Evans, David, Peake, Sandra, Kruger, Peter, McCullough, James, Johnk, Loki, Ghelani, Dhaval, Billot, Laurent, Shan, Sana, Meyer, Jason, Rajbhandari, Dorrilyn, Koch, Carolyn, Bellomo, Rinaldo, Burrell, Louise M., Young, Morag, Roberts, Michael, Mackenzie, Lorraine, Medley, Gregory, Dalton, Joshua and Venkatesh, Balasubramanian (2024). Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial. Intensive Care Medicine. doi: 10.1007/s00134-024-07616-z
Mathmann, Carmen D., Schultz, Thomas E., Cadena, Leslie C. Dominguez and Blumenthal, Antje (2024). Myddosomes in Toll-like receptor signaling-one to bind and rule them all. Immunology and Cell Biology, 102 (9), 752-756. doi: 10.1111/imcb.12816
Schlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8
Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Irwin, Adam (RSG member), Phillips, Natalie (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768
Rollo, Rachel F., Mori, Giorgia, Hill, Timothy A., Hillemann, Doris, Niemann, Stefan, Homolka, Susanne, Fairlie, David P. and Blumenthal, Antje (2023). Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis. Microbiology Spectrum, 11 (4). doi: 10.1128/spectrum.00465-23
Mattke, Adrian, Johnson, Kerry, Gibbons, Kristen, Long, Debbie, Robertson, Jeremy, Venugopal, Prem, Blumenthal, Antje, Schibler, Andreas and Schlapbach, Luregn (2023). Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial. JMIR Research Protocols, 12 e43760, 1-10. doi: 10.2196/43760
Enosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan and Man, Si Ming (2023). Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes. The EMBO Journal, 42 (6) e112558, e112558. doi: 10.15252/embj.2022112558
Donovan, Meg L., Bielefeldt‐Ohmann, Helle, Rollo, Rachel F., McPherson, Stephen, Schultz, Thomas E., Mori, Giorgia, Kling, Jessica C. and Blumenthal, Antje (2022). Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis. Immunology, 169 (1), 13-26. doi: 10.1111/imm.13606
Sim, Seen Ling, Blumenthal, Antje, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration. Frontiers in Endocrinology, 13 957833, 957833. doi: 10.3389/fendo.2022.957833
Ramnath, Divya, Das Gupta, Kaustav, Wang, Yizhuo, Abrol, Rishika, Curson, James E. B., Lim, Junxian, Reid, Robert C., Mansell, Ashley, Blumenthal, Antje, Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2022). The histone deacetylase Hdac7 supports LPS‐inducible glycolysis and Il‐1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111 (2), 327-336. doi: 10.1002/jlb.2mr1021-260r
Wilson, Alicia S., Randall, Katrina L., Pettitt, Jessica A., Ellyard, Julia I., Blumenthal, Antje, Enders, Anselm, Quah, Benjamin J., Bopp, Tobias, Parish, Christopher R. and Brüstle, Anne (2022). Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2. Nature Communications, 13 (1) 528, 528. doi: 10.1038/s41467-022-28172-4
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
Sinha, Roma, Ngo, Minh Dao, Bartlett, Stacey, Bielefeldt-Ohmann, Helle, Keshvari, Sahar, Hasnain, Sumaira Z., Donovan, Meg L., Kling, Jessica C., Blumenthal, Antje, Chen, Chen, Short, Kirsty R. and Ronacher, Katharina (2021). Pre-Diabetes Increases Tuberculosis Disease Severity, While High Body Fat Without Impaired Glucose Tolerance Is Protective. Frontiers in Cellular and Infection Microbiology, 11 691823, 691823. doi: 10.3389/fcimb.2021.691823
Cohen, Jeremy, Blumenthal, Antje, Cuellar-Partida, Gabriel, Evans, David M., Finfer, Simon, Li, Qiang, Ljungberg, Johanna, Myburgh, John, Peach, Elizabeth, Powell, Joseph, Rajbhandari, Dorrilyn, Rhodes, Andrew, Senabouth, Anne and Venkatesh, Balasubramanian (2021). The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock. Intensive Care Medicine, 47 (9), 974-983. doi: 10.1007/s00134-021-06464-5
Mori, Giorgia, Morrison, Mark and Blumenthal, Antje (2021). Microbiome-immune interactions in tuberculosis. PLoS Pathogens, 17 (4) e1009377, e1009377. doi: 10.1371/journal.ppat.1009377
Gibbons, Kristen S., Schlapbach, Luregn J., Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d'Udekem, Yves, Alphonso, Nelson, Winlaw, David, Johnson, Kerry, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick and Schibler, Andreas (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58.
Gibbons, Kristen S., Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, Schlapbach, Luregn J., Johnson, Kerry, Horton, Stephen B., Long, Debbie A., Beca, John, Erickson, Simon, Festa, Marino, d’Udekem, Yves, Alphonso, Nelson, Winlaw, David, Delzoppo, Carmel, van Loon, Kim, Gannon, Brenda, Fooken, Jonas, Blumenthal, Antje, Young, Paul J., Butt, Warwick, Schibler, Andreas, Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, Paediatric Intensive Care Unit, Queensland Children’s Hospital, Children’s Health Queensland, Brisbane, Queensland, Australia, Department of Intensive Care Medicine and Neonatology, and Children’s Research Center, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland, Cardiac Surgical Unit, Royal Children’s Hospital, Melbourne, Victoria, Australia, Faculty of Medicine, Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia, Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, Queensland, Australia, Paediatric Intensive Care Unit, Queensland Children’s Hospital, Children’s Health Queensland, Brisbane, Queensland, Australia, Paediatric Intensive Care Unit, Starship Children’s Hospital, Auckland, New Zealand ... Paediatric Intensive Care Unit, Queensland Children’s Hospital, Children’s Health Queensland, Brisbane, Queensland, Australia (2021). Statistical analysis plan for the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial. Critical Care and Resuscitation, 23 (1), 47-58. doi: 10.51893/2021.1.oa4
Burgess, M., Chen, Y. C.E., Mapp, S., Blumenthal, A., Mollee, P., Gill, D. and Saunders, N. A. (2021). Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients (Oncogene, (2020), 39, 35, (5756-5767), 10.1038/s41388-020-01394-w). Oncogene, 40 (6), 1203-1203. doi: 10.1038/s41388-020-01619-y
Chen, Yu-Chen Enya, Burgess, Melinda, Mapp, Sally, Mollee, Peter, Gill, Devinder, Blumenthal, Antje and Saunders, Nicholas A. (2021). SIRPα suppresses response to therapeutic antibodies by nurse like cells from chronic lymphocytic leukemia patients. Frontiers in Immunology, 11 610523, 1-12. doi: 10.3389/fimmu.2020.610523
Domínguez Cadena, Leslie C., Schultz, Thomas E., Zamoshnikova, Alina, Donovan, Meg L., Mathmann, Carmen D., Yu, Chien-Hsiung, Mori, Giorgia, Stow, Jennifer L and Blumenthal, Antje (2021). Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection. Immunology and Cell Biology, 99 (10), 1067-1076. doi: 10.1111/imcb.12503
Mohamed, Osama G., Khalil, Zeinab G., Salim, Angela A., Cui, Hui, Blumenthal, Antje and Capon, Robert J. (2020). Lincolnenins A–D: isomeric bactericidal bianthracenes from Streptomyces lincolnensis. The Journal of Organic Chemistry, 86 (16) acs.joc.0c02492, 11011-11018. doi: 10.1021/acs.joc.0c02492
D'Urso, Shannon, Rajbhandari, Dorrilyn, Peach, Elizabeth, De Guzman, Erika, Li, Qiang, Medland, Sarah E., Gordon, Scott D., Martin, Nicholas G., Ligthart, Symen, Brown, Matthew A., Powell, Joseph, McArthur, Colin, Rhodes, Andrew, Meyer, Jason, Finfer, Simon, Myburgh, John, Blumenthal, Antje, Cohen, Jeremy, Venkatesh, Balasubramanian, Cuellar-Partida, Gabriel and Evans, David M. (2020). Septic shock: a genomewide association study and polygenic risk score analysis. Twin Research and Human Genetics, 23 (4) PII S1832427420000602, 204-213. doi: 10.1017/thg.2020.60
Burgess, M., Chen, U. C. E., Mapp, S., Blumenthal, A., Mollee, P., Gill, D. and Saunders, N. A. (2020). HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients. Oncogene, 39 (35), 5756-5767. doi: 10.1038/s41388-020-01394-w
Kapetanovic, Ronan, Afroz, Syeda Farhana, Ramnath, Divya, Lawrence, Grace M.E.P., Okada, Takashi, Curson, James E.B., Bruin, Jost, Fairlie, David P., Schroder, Kate, St John, Justin C., Blumenthal, Antje and Sweet, Matthew J. (2020). Lipopolysaccharide promotes Drp1‐dependent mitochondrial fission and associated inflammatory responses in macrophages. Immunology and Cell Biology, 98 (7) imcb.12363, 528-539. doi: 10.1111/imcb.12363
Blumenthal, Antje, Martin-Orozco, Elena, McBride, Jere W., Carson, Dennis A. and Sen, Malini (2020). Editorial: Wnt signaling in immune cell regulation during microbial infection and cancer. Frontiers in Immunology, 11 1133, 1133. doi: 10.3389/fimmu.2020.01133
Das Gupta, Kaustav, Shakespear, Melanie R., Curson, James E.B., Murthy, Ambika M.V., Iyer, Abishek, Hodson, Mark P., Ramnath, Divya, Tillu, Vikas A., von Pein, Jessica B., Reid, Robert C., Tunny, Kathryn, Hohenhaus, Daniel M., Moradi, Shayli Varasteh, Kelly, Gregory M., Kobayashi, Takumi, Gunter, Jennifer H., Stevenson, Alexander J., Xu, Weijun, Luo, Lin, Jones, Alun, Johnston, Wayne A., Blumenthal, Antje, Alexandrov, Kirill, Collins, Brett M., Stow, Jennifer L., Fairlie, David P. and Sweet, Matthew J. (2020). Class IIa histone deacetylases drive toll-like receptor-inducible glycolysis and macrophage inflammatory responses via pyruvate kinase M2. Cell Reports, 30 (8), 2712-2728.e8. doi: 10.1016/j.celrep.2020.02.007
Ljungberg, Johanna K., Kling, Jessica C., Tran, Thao Thanh and Blumenthal, Antje (2019). Functions of the WNT signaling network in shaping host responses to infection. Frontiers in Immunology, 10 2521, 2521. doi: 10.3389/fimmu.2019.02521
Schlapbach, Luregn J., Horton, Stephen Brian, Long, Debbie Amanda, Beca, John, Erickson, Simon, Festa, Marino, d’Udekem, Yves, Alphonso, Nelson, Winlaw, David, Johnson, Kerry, Delzoppo, Carmel, van Loon, Kim, Gannon, B., Fooken, Jonas, Blumenthal, Antje, Young, Paul, Jones, Mark, Butt, Warwick and Schibler, Andreas (2019). Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial. BMJ Open, 9 (8) e026664, e026664. doi: 10.1136/bmjopen-2018-026664
Khalil, Zeinab G., Hill, Timothy A., De Leon Rodriguez, Luis M., Lohman, Rink-Jan, Hoang, Huy N., Reiling, Norbert, Hillemann, Doris, Brimble, Margaret A., Fairlie, David, Blumenthal, Antje and Capon, Robert J. (2019). Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular. Antimicrobial Agents and Chemotherapy, 63 (3) e01773-18. doi: 10.1128/AAC.01773-18
Enya Chen, Yu-Chen, Burgess, Melinda, Mapp, Sally, Mollee, Peter, Gill, Devinder, Blumenthal, Antje and Saunders, Nicholas A. (2019). PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia. Leukemia, 34 (2), 451-461. doi: 10.1038/s41375-019-0556-z
Kling, Jessica C., Jordan, Margaret A., Pitt, Lauren A., Meiners, Jana, Thanh-Tran, Thao , Tran, Le Son , Nguyen, Tam T. K., Mittal, Deepak, Villani, Rehan, Steptoe, Raymond J., Khosrotehrani, Kiarash, Berzins, Stuart P., Baxter, Alan G., Godfrey, Dale I. and Blumenthal, Antje (2018). Temporal regulation of natural Killer T cell interferon gamma responses by beta-catenin-dependent and -independent Wnt signaling. Frontiers in Immunology, 9 (MAR) 483, 483. doi: 10.3389/fimmu.2018.00483
Chamoun, Michelle N., Blumenthal, Antje, Sullivan, Matthew J., Schembri, Mark A. and Ulett, Glen C. (2018). Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology, 44 (4), 1-22. doi: 10.1080/1040841X.2018.1426556
Schultz, Thomas E., Wiesmüller, Karl-Heinz, Lucas, Megan, Dobos, Karen M., Baxter, Alan G. and Blumenthal, Antje (2018). The N-terminal peptide moiety of the Mycobacterium tuberculosis 19 kDa lipoprotein harbors RP105-agonistic properties. Journal of Leukocyte Biology, 103 (2), 311-319. doi: 10.1002/JLB.2MA0517-190RR
Donovan, Meg L., Schultz, Thomas E., Duke, Taylor J. and Blumenthal, Antje (2017). Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological Consequences. Frontiers in Immunology, 8 (NOV) 1633, 1-16. doi: 10.3389/fimmu.2017.01633
Khalil, Zeinab G., Salim, Angela A., Vuong, Daniel, Crombie, Andrew, Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2017). Amycolatopsins A-C: antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494. The Journal of Antibiotics, 70 (12), 1097-1103. doi: 10.1038/ja.2017.119
Chen, Y. C. E., Mapp, S., Blumenthal, A., Burgess, M. L., Mazzieri, R., Mattarollo, S., Mollee, P., Gill, D. and Saunders, N. A. (2017). The duality of macrophage function in Chronic Lymphocytic Leukaemia. Biochimica et Biophysica Acta (BBA) Reviews on Cancer, 1868 (1), 176-182. doi: 10.1016/j.bbcan.2017.03.006
Noguchi, Shuhei, Arakawa, Takahiro, Fukuda, Shiro, Furuno, Masaaki, Hasegawa, Akira, Hori, Fumi, Ishikawa-Kato, Sachi, Kaida, Kaoru, Kaiho, Ai, Kanamori-Katayama, Mutsumi, Kawashima, Tsugumi, Kojima, Miki, Kubosaki, Atsutaka, Manabe, Ri-ichiroh, Murata, Mitsuyoshi, Nagao-Sato, Sayaka, Nakazato, Kenichi, Ninomiya, Noriko, Nishiyori-Sueki, Hiromi, Noma, Shohei, Saijyo, Eri, Saka, Akiko, Sakai, Mizuho, Simon, Christophe, Suzuki, Naoko, Tagami, Michihira, Watanabe, Shoko, Yoshida, Shigehiro, Arner, Peter ... Hayashizaki, Yoshihide (2017). FANTOM5 CAGE profiles of human and mouse samples. Scientific Data, 4 (1) 170112, 170112. doi: 10.1038/sdata.2017.112
Gatica-Andrades, Marcela, Vagenas, Dimitrios, Kling, Jessica, Nguyen, Tam T. K., Benham, Helen, Thomas, Ranjeny, Korner, Heinrich, Venkatesh, Bala, Cohen, Jeremy and Blumenthal, Antje (2017). WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice. Blood Advances, 1 (16), 1274-1286. doi: 10.1182/bloodadvances.2017006163
Overgaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole K., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017). CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 (3), 837-844. doi: 10.1189/jlb.1AB0217-065R
Kling, Jessica C. and Blumenthal, Antje (2017). Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes. Journal of Leukocyte Biology, 101 (4), 827-840. doi: 10.1189/jlb.1MR0616-272R
Wall, Adam A., Luo, Lin, Hung, Yu, Tong, Samuel J., Condon, Nicholas D., Blumenthal, Antje, Sweet, Matthew J. and Stow, Jennifer L. (2017). Small GTPase Rab8a-recruited phosphatidylinositol 3-kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors. Journal of Biological Chemistry, 292 (11), 4411-4422. doi: 10.1074/jbc.M116.766337
Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R. and Stacey, Katryn J. (2017). Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6. Immunology and Cell Biology, 95 (5), 491-495. doi: 10.1038/icb.2017.5
Schultz, Thomas E. and Blumenthal, Antje (2017). The RP105/MD-1 complex: molecular signaling mechanisms and pathophysiological implications. Journal of Leukocyte Biology, 101 (1), 183-192. doi: 10.1189/jlb.2VMR1215-582R
Cohen, Jeremy, Pretorius, Carel J., Ungerer, Jacobus P. J., Cardinal, John, Blumenthal, Antje, Presneill, Jeff, Gatica-Andrades, Marcela, Jarrett, Paul, Lassig-Smith, Melissa, Stuart, Janine, Dunlop, Rachel, Starr, Therese and Venkatesh, Bala (2016). Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity. Critical Care Medicine, 44 (6), 1034-1041. doi: 10.1097/CCM.0000000000001633
Ariffin, Juliana K., Kapetanovic, Ronan, Schaale, Kolja, Gatica-Andrades, Marcela, Blumenthal, Antje, Schroder, Kate and Sweet, Matthew J. (2016). The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology, 100 (1), 155-161. doi: 10.1189/jlb.2AB0815-339R
Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2015). Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 11 (12) e1005336. doi: 10.1371/journal.ppat.1005336
Irvine, Katharine M., Clouston, Andrew D., Gadd, Victoria L., Miller, Gregory C., Wong, Weng-Yew, Melino, Michelle, Maradana, Muralidhara Rao, MacDonald, Kelli, Lang, Richard A., Sweet, Matthew J., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in myeloid cells exacerbates liver fibrosis and the ductular reaction in chronic liver injury. Fibrogenesis and Tissue Repair, 8 (19) 19, 19. doi: 10.1186/s13069-015-0036-7
Yu, Chien-Hsiung, Micaroni, Massimo, Puyskens, Andreas, Schultz, Thomas E., Yeo, Jeremy Changyu, Stanley, Amanda C., Lucas, Megan, Kurihara, Jade, Dobos, Karen M., Stow, Jennifer L. and Blumenthal, Antje (2015). RP105 engages phosphatidylinositol 3-kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection. Journal of Immunology, 195 (8), 3890-3900. doi: 10.4049/jimmunol.1500017
Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje and Capon, Robert J. (2015). Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.. Journal of Natural Products, 78 (4), 949-952. doi: 10.1021/acs.jnatprod.5b00095
Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015). Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 (4), 1065-1073. doi: 10.1016/j.jaci.2015.02.032
Gaur, R. L., Ren, K., Blumenthal, A., Bhamidi, S., Gibbs, S., Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014). Correction: LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis (vol 10, e1004376, 2014). Plos Pathogens, 10 (10). doi: 10.1371/journal.ppat.1004489
Khalil, Zeinab G., Salim, Angela A., Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2014). Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. Organic Letters, 16 (19), 5120-5123. doi: 10.1021/ol502472c
Gaur, Rajiv L., Ren, Kangning, Blumenthal, Antje, Bhamidi, Suresh, Gibbs, Sara, Jackson, Mary, Zare, Richard N., Ehrt, Sabine, Ernst, Joel D. and Banaei, Niaz (2014). LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. PLoS Pathogens, 10 (9), e1004376.1-e1004376.14. doi: 10.1371/journal.ppat.1004376
Gosmann, Christina, Mattarollo, Stephen R., Bridge, Jennifer A., Frazer, Ian H. and Blumenthal, Antje (2014). IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia. Journal of Immunology, 193 (5), 2248-2257. doi: 10.4049/jimmunol.1400216
Inder, Kerry L., Ruelcke, Jayde E., Petelin, Lara, Moon, Hyeongsun, Choi, Eunju, Rae, James, Blumenthal, Antje, Hutmacher, Dietmar, Saunders, Nicholas A., Stow, Jennifer L., Parton, Robert G. and Hill, Michelle M. (2014). Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of Extracellular Vesicles, 3 (1) 23784, 23784.1-23784.14. doi: 10.3402/jev.v3.23784
Gosmann, Christina, Frazer, Ian H., Mattarollo, Stephen R. and Blumenthal, Antje (2014). IL-18, but not IL-12, induces production of IFN-gamma in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin. Journal of Investigative Dermatology, 134 (10), 2562-2569. doi: 10.1038/jid.2014.201
Trujillo, Carolina, Blumenthal, Antje, Marrero, Joeli, Rhee, Kyu Y., Schnappinger, Dirk and Ehrt, Sabine (2014). Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection. mBio, 5 (2) e00085-14, e00085-14.1-e00085-14.12. doi: 10.1128/mBio.00085-14
Raju, Ritesh, Khalil, Zeinab G., Piggott, Andrew M., Blumenthal, Antje, Gardiner, Donald L., Skinner-Adams, Tina S. and Capon, Robert J. (2014). Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244). Organic Letters, 16 (6), 1716-1719. doi: 10.1021/ol5003913
Forest, Alistair R. R., Kawaji, Hideya, Rehli, Michael, Baillie, J. Kenneth, De Hoon, Michael J. L., Haberle, Vanja, Lassmann, Timo, Kulakovskiy, Ivan V., Lizio, Marina, Itoh, Masayoshi, Andersson, Robin, Mungall, Christopher J., Meehan, Terrence F., Schmeier, Sebastian, Bertin, Nicholas, Jorgensen, Mette, Dimont, Emmanuel, Arner, Erik, Schmidl, Christian, Schaefer, Ulf, Medvedeva, Yulia A., Plessy, Charles, Vitezic, Morana, Severin, Jessica, Semple, Colin A., Ishizu, Yuri, Young, Robert S., Francescatto, Margherita, Altschuler, Intikhab ... Hayashizaki, Yoshihide (2014). A promoter-level mammalian expression atlas. Nature, 507 (7493), 462-470. doi: 10.1038/nature13182
Yu, C.-H., Nguyen, T.T.K., Irvine, K.M., Sweet, M.J., Frazer, I.H. and Blumenthal, A. (2014). Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4. European Journal of Immunology, 44 (5), 1480-1490. doi: 10.1002/eji.201343959
Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222
McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje and McMillan, Nigel A. J. (2013). Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Molecular Therapy - Nucleic Acid, 2 (1) e96, e96. doi: 10.1038/mtna.2013.22
Skalamera, Dubravka, Dahmer, Mareike, Purdon, Amy S., Wilson, Benjamin M., Ranall, Max V., Blumenthal, Antje, Gabrielli, Brian and Gonda, Thomas J. (2012). Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer. PloS One, 7 (12) e51733, e51733.1-e51733.15. doi: 10.1371/journal.pone.0051733
Blumenthal, Antje, Nagalingam, Gayathri, Huch, Jennifer H., Walker, Lara, Guillemin, Gilles J., Smythe, George A., Ehrt, Sabine, Britton, Warwick J. and Saunders, Bernadette M. (2012). M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PloS One, 7 (5) e37314, e37314.1-e37314.11. doi: 10.1371/journal.pone.0037314
Park, Sae Woong, Klotzsche, Marcus, Wilson, Daniel J., Boshoff, Helena I., Eoh, Hyungjin, Manjunatha, Ujjini, Blumenthal, Antje, Rhee, Kyu, Barry III, Clifton E., Aldrich, Courtney C., Ehrt, Sabine and Schnappinger, Dirk (2011). Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathogens, 7 (9) e1002264, e1002264.1-e1002264.10. doi: 10.1371/journal.ppat.1002264
Blumenthal, Antje, Trujillo, Carolina, Ehrt, Sabine and Schnappinger, Dirk (2010). Simultaneous analysis of multiple mycobacterium tuberculosis knockdown mutants in vitro and in vivo. PLoS One, 5 (12) e15667, e15667-1-e15667-12. doi: 10.1371/journal.pone.0015667
Seimon, Tracie A., Kim, Mi-Jeong, Blumenthal, Antje, Koo, Jovanka, Ehrt, Sabine, Wainwright, Helen, Bekker, Linda-Gail, Kaplan, Gilla, Nathan, Carl, Tabas, Ira and Russell, David G. (2010). Induction of ER stress in macrophages of tuberculosis granulomas. PLoS One, 5 (9) e12772, e12772.1-e12772.12. doi: 10.1371/journal.pone.0012772
Blumenthal, Antje, Isovski, Flonza and Rhee, Kyu Y. (2009). Tuberculosis and host metabolism: ancient associations, fresh insights. Translational Research, 154 (1), 7-14. doi: 10.1016/j.trsl.2009.04.004
Blumenthal, A., Kobayashi, Toshihiko, Pierini, Lynda M., Banaei, Niaz, Ernst, Joel D., Miyake, Kensuke and Ehrt, Sabine (2009). RP105 Facilitates Macrophage Activation by Mycobacterium tuberculosis Lipoproteins. Cell Host and Microbe, 5 (1), 35-46. doi: 10.1016/j.chom.2008.12.002
Blumenthal, Antje, Ehlers, Stefan, Lauber, Jörg, Buer, Jan, Lange, Christoph, Goldmann, Torsten, Heine, Holger, Brandt, Ernst and Reiling, Norbert (2006). The wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood, 108 (3), 965-973. doi: 10.1182/blood-2005-12-5046
Shi, Shuangping, Blumenthal, Antje, Hickey, Christopher M., Gandotra, Sheetal, Levy, David and Ehrt, Sabine (2005). Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alpha beta receptor and STAT1. Journal of Immunology, 175 (5), 3318-3328. doi: 10.4049/jimmunol.175.5.3318
Blumenthal, Antje, Lauber, Jorg, Hoffmann, Reinhard, Ernst, Martin, Keller, Christine, Buer, Jan, Ehlers, Stefan and Reiling, Norbert (2005). Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics. Infection and Immunity, 73 (6), 3330-3341. doi: 10.1128/IAI.73.6.3330-3341.2005
Mohamed, S. A., Wesch, D., Blumenthal, A., Bruse, P., Windler, K., Ernst, M., Kabelitz, D., Oehmichen, M. and Meissner, C. (2004). Detection of the 4977 bp deletion of mitochondrial DNA in different human blood cells. Experimental Gerontology, 39 (2), 181-188. doi: 10.1016/j.exger.2003.10.011
Keller, Christopher, Lauber, Joerg, Blumenthal, Antje, Buer, Jan and Ehlers, Stefan (2004). Resistance and susceptibility to tuberculosis analysed at the transcriptome level: Lessons from mouse macrophages. Tuberculosis, 84 (3-4), 144-158. doi: 10.1016/j.tube.2003.12.003
Gronow, Sabine, Noah, Christian, Blumenthal, Antje, Lindner, Buko and Brade, Helmut (2003). Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 and characterization of its chemical and biological properties. Journal of Biological Chemistry, 278 (3), 1647-1655. doi: 10.1074/jbc.M206942200
Blumenthal, Antje, Ehlers, Stefan, Ernst, Martin, Flad, Hans-Dieter and Reiling, Norbert (2002). Control of mycobacterial replication in human macrophages: Roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways. Infection and Immunity, 70 (9), 4961-4967. doi: 10.1128/IAI.70.9.4961-4967.2002
Reiling, N., Blumenthal, A., Flad, H. D., Ernst, M. and Ehlers, S. (2001). Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. Journal of Immunology, 167 (6), 3339-3345. doi: 10.4049/jimmunol.167.6.3339
Conference Papers
Sim, S., Kaur, S., Styke, C., Millard, S., Blumenthal, A., Pettit, A. and Khosrotehrani, K. (2023). 1511 Macrophages regulate endothelial progenitors’ quiescence and self-renewal during homeostasis and cutaneous wound healing via paracrine signaling. 1st International Societies for Investigative Dermatology Meeting, Tokyo, Japan, 10 - 13 May 2023. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jid.2023.03.1528
Mathmann, Carmen, Schultz, Thomas, Ongtengco, Cherica Felize J., Dalton, Emma, Domínguez Cadena, Leslie C., Zamoshnikova, Alina, Stow, Jennifer L. and Blumenthal, Antje (2023). SPATIOTEMPORAL REGULATION OF RP105 SUBCELLULAR LOCALIZATION SHAPES ENDOSOMAL TLR4 SIGNALING. IMMUNOLOGY 2023 Meeting, Washington, DC, United States, 11 - 15 May 2023. Rockville, MD, United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.160.06
Donovan, C., Kim, R., Gomez, H., Liu, G., Blumenthal, A. and Hansbro, P. (2020). Wntless in myeloid cells drives bleomycin-induced lung pathology. TSANZSRS 2020 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Melbourne, VIC Australia, 27-31 March 2020. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13777
Chen, Yu-Chen Enya, Burgess, Melinda Lea, Blumenthal, Antje, Mapp, Sally, Mollee, Peter, Gill, Devinder and Saunders, Nicholas Andrew (2018). Activation of Fc Gamma Receptor-Dependent Responses to Therapeutic Antibodies By Nurse like Cells Requires PI3Kdelta. 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA United States, 1-4 December 2018. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2018-99-109719
Tran, T. T., Andrades, M. G., Nguyen, T. T. K., Wyer, O., Kling, J. C., Begun, J. and Blumenthal, A. (2016). An inhibitor of Wnt protein production improves host control of Listeria monocytogenes. ICI 2016 International Congress of Immunology, Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH Verlag. doi: 10.1002/eji.201670200
Kling, J., Meiners, J. and Blumenthal, A. (2016). Wnt proteins drive the IL-12/IFN-gamma-axis in response to the Natural Killer T cell antigen, alpha-galactosylceramide. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200
Irvine, Katharine, Clouston, Andrew D., Blumenthal, Antje and Powell, Elizabeth E. (2015). Deletion of Wntless in macrophages exacerbates liver fibrosis and the ductular reaction in chronic liver injury. 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, United States, Nov 13-17, 2015. Hoboken, United States: John Wiley & Sons.
Ullah, M. A., Revez, J., Loh, Z., Simpson, J., Zhang,, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. A. and Phipps, S. (2015). IL-6R blockade attenuates experimental allergic asthma associated with activation of the IL-6 trans-signalling pathway. Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Barcelona, Spain, 6-10 June 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell.
Irvine, K. M., Clouston, A. D., Blumenthal, A. and Powell, E. E. (2015). Blocking Wnt protein secretion from macrophages exacerbates liver fibrosis and hepatic progenitor cell activation. GESA-AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week, Brisbane, QLD, Australia, 28 September - 2 October 2015. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/jgh.13087
Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, 27 March - 1 April 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12494_9
Gatica-Andrades, M. D., Nguyen, T. T. K., Schultz, T. E., Wyer, O. J. K., Melo-Bolivar, J., Walker, M. J., Frazer, I. H., Barnett, T. C. and Blumenthal, A. (2014). Interference with Wnt pathway improves host control of Listeria monocytogenes in vivo. British Society for Immunology Annual Congress 2014, Brighton, United Kingdom, 1-4 December 2014. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/imm.12406
Blumenthal, A., Ehlers, S., Ernst, M., Flad, H.-D. and Reiling, N. (2000). Infection of human monocyte-derived macrophages with Mycobacterium avium: MAP kinase activation is inversely correlated to bacterial survival in vitro. Joint Annual Meeting of the German and Dutch Societies of Immunology, Duseldorf, Germany, 29 November - 02 December 2000. Jena, Germany: Urban und Fischer Verlag.
Reiling, N., Blumenthal, A., Flad, H.-D., Ernst, M. and Ehlers, S. (2000). Mycobacteria-induced TNF and IL-10 formation by human macrophages: the role of MAP kinases. Joint Annual Meeting of the German and Dutch Societies of Immunology, Duseldorf, Germany, 29 November - 02 December 2000. Jena, Germany: Urban und Fischer Verlag.