Professor Emma Hamilton-Williams
Professorial Research Fellow
Frazer Institute
+61 7 344 36989
Professor Emma Hamilton-Williams leads the Type 1 diabetes pathogenesis and therapy group.
Research projects
- Early-life factors and the gut microbiota as drivers of islet autoimmunity and type 1 diabetes
- Gut-microbiome targeted therapeutics for type 1 diabetes
- Antigen-specific immunotherapy for type 1 diabetes
- Molecular mechanisms of tolerance for suppression of autoreactive T cells
Researcher biography
Associate Professor Emma Hamilton-Williams' career focuses on understanding how immune tolerance is disrupted leading to the development of the autoimmune disease type 1 diabetes. She received her PhD from the Australian National University in 2001, followed by postdoctoral training in Germany and the Scripps Research Institute in the USA.
In 2012, she started a laboratory at the Frazer Institute, University of Queensland where she investigates the gut microbiota as a potential trigger or therapy target for type 1 diabetes, as well as developing an immunotherapy for type 1 diabetes. The overall aim of her research is to find new ways to prevent or treat the underlying immune dysfunction causing autoimmunity.
She is Chief Scientific Officer for an Australia-wide pregnancy-birth cohort study of children at increased risk of type 1 diabetes, which aims to uncover the environmental drivers of this disease. Her laboratory uses big-data approaches including proteomics, metabolomics and metagenomics to understand the function of the gut microbiota linked to disease.
She recently conducted a clinical trial of a microbiome-targeting biotherapy aimed at restoring a healthy microbiome and immune tolerance, with an ultimate aim of preventing type 1 diabetes.
Book Chapters
Tillett, Bree J. and Hamilton-Williams, Emma E. (2020). Microbiota derived factors as drivers of type 1 diabetes. The microbiome in health and disease. (pp. 215-235) Cambridge, MA United States: Academic Press.
Hamilton-Williams, E. E. and Kurts, C. (2006). Influence of toll-like receptor ligands and danger signals on T cell cross-tolerance. Towards an understanding of initiating T cell immunity. (pp. 147-168) edited by Anthony T. Vella. Kerala, India: Research Signpost.
Journal Articles
Tillett, Bree J., Dwiyanto, Jacky, Secombe, Kate R., George, Thomas, Zhang, Vivian, Anderson, Dovile, Duggan, Emily, Giri, Rabina, Loo, Dorothy, Stoll, Thomas, Morrison, Mark, Begun, Jakob, Hill, Michelle M., Gurzov, Esteban N., Bell, Kirstine J., Saad, Sonia, Barlow, Christopher K., Creek, Darren J., Chong, Chun Wie, Mariño, Eliana and Hamilton-Williams, Emma E. (2025). SCFA biotherapy delays diabetes in humanized gnotobiotic mice by remodeling mucosal homeostasis and metabolome. Nature Communications, 16 (1) 2893, 1-20. doi: 10.1038/s41467-025-58319-y
Thomson, Rebecca L, Brown, James D, Oakey, Helena, Palmer, Kirsten, Ashwood, Pat, Penno, Megan A S, McGorm, Kelly J, Battersby, Rachel, Colman, Peter G, Craig, Maria E, Davis, Elizabeth A, Huynh, Tony, Harrison, Leonard C, Haynes, Aveni, Sinnott, Richard O, Vuillermin, Peter J, Wentworth, John M, Soldatos, Georgia, Couper, Jennifer J, ENDIA Study Group and Hamilton-Williams, Emma (ENDIA Study Group member) (2024). Dietary patterns during pregnancy and maternal and birth outcomes in women with type 1 diabetes: the Environmental Determinants of Islet Autoimmunity (ENDIA) study. Diabetologia, 67 (11), 2420-2432. doi: 10.1007/s00125-024-06259-5
Haynes, Aveni, Tully, Alexandra, Smith, Grant J, Penno, Megan A S, Craig, Maria E, Wentworth, John M, Huynh, Tony, Colman, Peter G, Soldatos, Georgia, Anderson, Amanda J, McGorm, Kelly J, Oakey, Helena, Couper, Jennifer J, Davis, Elizabeth A, ENDIA Study Group and Hamilton-Williams, Emma (ENDIA Study Group member) (2024). Early dysglycemia is detectable using continuous glucose monitoring in very young children at risk of type 1 diabetes. Diabetes Care, 47 (10), 1750-1756. doi: 10.2337/dc24-0540
Thomson, Rebecca L, Oakey, Helena, Haynes, Aveni, Craig, Maria E, Harrison, Leonard C, Wentworth, John M, Anderson, Amanda, Ashwood, Pat, Barry, Simon, Brittain, Bek, Brown, James D, Colman, Peter G, Davis, Elizabeth A, Hamilton-Williams, Emma, Huynh, Dao, Huynh, Tony, Kim, Ki-Wook, McGorm, Kelly J, Morahan, Grant, Rawlinson, William, Sinnott, Richard O, Soldatos, Georgia, Tye-Din, Jason A, Vuillermin, Peter J, Penno, Megan A S and Couper, Jennifer J (2024). Environmental Determinants of Islet Autoimmunity (ENDIA) longitudinal prospective pregnancy to childhood cohort study of Australian children at risk of type 1 diabetes: parental demographics and birth information. BMJ Open Diabetes Research & Care, 12 (4) e004130, 1-13. doi: 10.1136/bmjdrc-2024-004130
Budden, Kurtis F, Shukla, Shakti D, Bowerman, Kate L, Vaughan, Annalicia, Gellatly, Shaan L, Wood, David L A, Lachner, Nancy, Idrees, Sobia, Rehman, Saima Firdous, Faiz, Alen, Patel, Vyoma K, Donovan, Chantal, Alemao, Charlotte A, Shen, Sj, Amorim, Nadia, Majumder, Rajib, Vanka, Kanth S, Mason, Jazz, Haw, Tatt Jhong, Tillet, Bree, Fricker, Michael, Keely, Simon, Hansbro, Nicole, Belz, Gabrielle T, Horvat, Jay, Ashhurst, Thomas, van Vreden, Caryn, McGuire, Helen, Fazekas de St Groth, Barbara ... Hansbro, Philip M (2024). Faecal microbial transfer and complex carbohydrates mediate protection against COPD. Gut, 73 (5), 751-769. doi: 10.1136/gutjnl-2023-330521
Oakey, Helena, Giles, Lynne C, Thomson, Rebecca L, Lê Cao, Kim-Anh, Ashwood, Pat, Brown, James D, Knight, Emma J, Barry, Simon C, Craig, Maria E, Colman, Peter G, Davis, Elizabeth A, Hamilton-Williams, Emma E, Harrison, Leonard C, Haynes, Aveni, Kim, Ki Wook, Mallitt, Kylie-Ann, McGorm, Kelly, Morahan, Grant, Rawlinson, William D, Sinnott, Richard O, Soldatos, Georgia, Wentworth, John M, Couper, Jennifer J, Penno, Megan A S and ENDIA Study Group (2023). Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort. Annals of Medicine, 55 (1) 2198255, 1-12. doi: 10.1080/07853890.2023.2198255
Harrison, Leonard C., Bandala-Sanchez, Esther, Oakey, Helena, Colman, Peter G., Watson, Kelly, Kim, Ki Wook, Wu, Roy, Hamilton-Williams, Emma E, Stone, Natalie L., Haynes, Aveni, Thomson, Rebecca L., Vuillermin, Peter J., Soldatos, Georgia, Rawlinson, William D., McGorm, Kelly J., Morahan, Grant, Sinnott, Richard O., Barry, Simon C., Wentworth, John M., Couper, Jennifer J., Penno, Megan As and ENDIA Study Group (2023). A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes. Journal of Diabetes Investigation, 14 (9), 1092-1100. doi: 10.1111/jdi.14031
McGorm, Kelly D., Brown, James G., Roberts, Alison, Greenbank, Susan, Brasacchio, Daniella, Sawyer, Alyssa C. P., Oakey, Helena G., Colman, Peter E., Craig, Maria A., Davis, Elizabeth, Soldatos, Georgia L., Thomson, Rebecca M., Wentworth, John J., Couper, Jennifer, Penno, Megan A. S., ENDIA Study Group and Hamilton-Williams, Emma E. (2023). Experiences of caregivers and at-risk children enrolled in a prospective pregnancy-birth cohort study into the causes of type 1 diabetes: the ENDIA Study. Children, 10 (4) 637, 1-12. doi: 10.3390/children10040637
Brenu, Ekua W., Harris, Mark and Hamilton-Williams, Emma E. (2023). Circulating biomarkers during progression to type 1 diabetes: a systematic review. Frontiers in Endocrinology, 14 1117076, 1117076. doi: 10.3389/fendo.2023.1117076
Okada, Mirei, Zhang, Vivian, Loaiza Naranjo, Jeniffer D., Tillett, Bree J., Wong, F. Susan, Steptoe, Raymond J., Bergot, Anne‐Sophie and Hamilton‐Williams, Emma E (2023). Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry. Immunology and Cell Biology, 101 (1), 36-48. doi: 10.1111/imcb.12593
Gavin, Patrick G., Kim, Ki Wook, Craig, Maria E., Hill, Michelle M. and Hamilton-Williams, Emma E. (2022). Multi-omic interactions in the gut of children at the onset of islet autoimmunity. Microbiome, 10 (1) 230, 230. doi: 10.1186/s40168-022-01425-6
Hall, Madeleine, Oakey, Helena, Penno, Megan A. S., McGorm, Kelly, Anderson, Amanda J., Ashwood, Pat, Colman, Peter G., Craig, Maria E., Davis, Elizabeth A., Harris, Mark, Harrison, Leonard C., Haynes, Aveni, Morbey, Claire, Sinnott, Richard O., Soldatos, Georgia, Vuillermin, Peter J., Wentworth, John M., Thomson, Rebecca L., Couper, Jennifer J., ENDIA Study Group., Barry, Simon C., Craig, Maria E., Colman, Peter G., Couper, Jennifer J., Davis, Elizabeth A., Harris, Mark, Harrison, Leonard C., Haynes, Aveni, Kim, Ki Wook ... Cavenett, Leanne (2022). Mental health during late pregnancy and postpartum in mothers with and without type 1 diabetes: The ENDIA study. Diabetes Care, 45 (5), 1082-1090. doi: 10.2337/dc21-2335
Bandala-Sanchez, Esther, Roth-Schulze, Alexandra J., Oakey, Helena, Penno, Megan A.S., Bediaga, Naiara G., Naselli, Gaetano, Ngui, Katrina M., Smith, Alannah D., Huang, Dexing, Zozaya-Valdes, Enrique, Thomson, Rebecca L., Brown, James D., Vuillermin, Peter J., Barry, Simon C., Craig, Maria E., Rawlinson, William D., Davis, Elizabeth A., Harris, Mark, Soldatos, Georgia, Colman, Peter G., Wentworth, John M., Haynes, Aveni, Morahan, Grant, Sinnott, Richard O., Papenfuss, Anthony T., Couper, Jennifer J., Harrison, Leonard C., on behalf of the ENDIA Study Group and Hamilton-Williams, Emma (2022). Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation. Diabetes Research and Clinical Practice, 184 109189, 1-23. doi: 10.1016/j.diabres.2022.109189
Bell, Kirstine J., Saad, Sonia, Tillett, Bree J., McGuire, Helen M., Bordbar, Sara, Yap, Yu Anne, Nguyen, Long T., Wilkins, Marc R., Corley, Susan, Brodie, Shannon, Duong, Sussan, Wright, Courtney J., Twigg, Stephen, de St Groth, Barbara Fazekas, Harrison, Leonard C., Mackay, Charles R., Gurzov, Esteban N., Hamilton-Williams, Emma E. and Mariño, Eliana (2022). Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation. Microbiome, 10 (1) 9, 9. doi: 10.1186/s40168-021-01193-9
Buckle, Irina, Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Zhang, Vivian, Talekar, Meghna, Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2022). Tolerance induction by liposomes targeting a single CD8 epitope IGRP in a model of type 1 diabetes is impeded by co-targeting a CD4 islet epitope. Immunology and Cell Biology, 100 (1), 33-48. doi: 10.1111/imcb.12506
Roth-Schulze, Alexandra J., Penno, Megan A. S., Ngui, Katrina M., Oakey, Helena, Bandala-Sanchez, Esther, Smith, Alannah D., Allnutt, Theo R., Thomson, Rebecca L., Vuillermin, Peter J., Craig, Maria E., Rawlinson, William D., Davis, Elizabeth A., Harris, Mark, Soldatos, Georgia, Colman, Peter G., Wentworth, John M., Haynes, Aveni, Barry, Simon C., Sinnott, Richard O., Morahan, Grant, Bediaga, Naiara G., Smyth, Gordon K., Papenfuss, Anthony T., Couper, Jennifer J., Harrison, Leonard C., ENDIA Study Group and Hamilton-Williams, Emma (2021). Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome. Microbiome, 9 (1) 167, 167. doi: 10.1186/s40168-021-01104-y
Rødahl, Inga, Gotley, James, Andersen, Stacey B., Yu, Meihua, Mehdi, Ahmed M., Christ, Angelika N., Hamilton-Williams, Emma E., Frazer, Ian H., Lukowski, Samuel W. and Chandra, Janin (2021). Acquisition of murine splenic myeloid cells for protein and gene expression profiling by advanced flow cytometry and CITE-seq. STAR Protocols, 2 (4) 100842, 1-27. doi: 10.1016/j.xpro.2021.100842
Borg, Danielle, Rae, Kym, Fiveash, Corrine, Schagen, Johanna, James-McAlpine, Janelle, Friedlander, Frances, Thurston, Claire, Oliveri, Maria, Harmey, Theresa, Cavanagh, Erika, Edwards, Christopher, Fontanarosa, Davide, Perkins, Tony, de Zubicaray, Greig, Moritz, Karen, Kumar, Sailesh, Clifton, Vicki, Queensland Family Cohort Research Collaborative, Hamilton-Williams, Emma and Bora, Samudragupta (2021). Queensland Family Cohort: a study protocol. BMJ Open, 11 (6) e044463, 1-13. doi: 10.1136/bmjopen-2020-044463
Gavin, Patrick G., Wong, Justin, Loo, Dorothy, Zipris, Danny, Hill, Michelle M. and Hamilton-Williams, Emma E. (2021). Metaproteomic sample preparation methods bias the recovery of host and microbial proteins according to taxa and cellular compartment. Journal of Proteomics, 240 104219, 104219. doi: 10.1016/j.jprot.2021.104219
Hamilton-Williams, Emma E., Lorca, Graciela L., Norris, Jill M. and Dunne, Jessica L. (2021). A triple threat? The role of diet, nutrition, and the microbiota in T1D pathogenesis. Frontiers in Nutrition, 8 600756, 600756. doi: 10.3389/fnut.2021.600756
Musthaffa, Yassmin, Hamilton‐Williams, Emma E, Nel, Hendrik J., Bergot, Anne‐Sophie, Mehdi, Ahmed M., Harris, Mark and Thomas, Ranjeny (2021). Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes. Clinical & Translational Immunology, 10 (7) e1315, e1315. doi: 10.1002/cti2.1315
Yap, Yu Anne, McLeod, Keiran H., McKenzie, Craig I., Gavin, Patrick G., Davalos‐Salas, Mercedes, Richards, James L., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Eng, Vik Ven, Pearson, Jaclyn S., Hamilton‐Williams, Emma E., Mackay, Charles R. and Mariño, Eliana (2021). An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection. Clinical and Translational Immunology, 10 (1) e1233, e1233. doi: 10.1002/cti2.1233
Musthaffa, Yassmin, Nel, Hendrik J., Ramnoruth, Nishta, Patel, Swati, Hamilton-Williams, Emma E., Harris, Mark and Thomas, Ranjeny (2020). Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes. Frontiers in Immunology, 11 587469, 587469. doi: 10.3389/fimmu.2020.587469
Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Buckle, Irina and Hamilton-Williams, Emma E. (2020). A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes. Current Diabetes Reports, 20 (12) 70, 70. doi: 10.1007/s11892-020-01363-3
Bergot, Anne-Sophie, Buckle, Irina, Cikaluru, Sumana, Naranjo, Jennifer Loaiza, Wright, Casey Maree, Zheng, Guoliang, Talekar, Meghna, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2020). Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes. Journal of Immunology, 204 (7), ji1901128-1797. doi: 10.4049/jimmunol.1901128
Craig, Maria E., Kim, Ki Wook, Isaacs, Sonia R., Penno, Megan A., Hamilton-Williams, Emma E., Couper, Jennifer J. and Rawlinson, William D. (2019). Early-life factors contributing to type 1 diabetes. Diabetologia, 62 (10), 1823-1834. doi: 10.1007/s00125-019-4942-x
Gavin, Patrick G. and Hamilton-Williams, Emma E. (2019). The gut microbiota in type 1 diabetes: friend or foe?. Current Opinion in Endocrinology, Diabetes and Obesity, 26 (4), 207-212. doi: 10.1097/MED.0000000000000483
Mullaney, Jane A., Stephens, Juliette E., Geeling, Brooke E. and Hamilton-Williams, Emma E. (2018). Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice. Immunology and Cell Biology, 97 (1), 97-103. doi: 10.1111/imcb.12201
Gavin, Patrick G., Mullaney, Jane A., Loo, Dorothy, Cao, Kim-Anh Lê, Gottlieb, Peter A., Hill, Michelle M., Zipris, Danny and Hamilton-Williams, Emma E. (2018). Intestinal metaproteomics reveals host-microbiota interactions in subjects at risk for Type 1 Diabetes. Diabetes Care, 41 (10), 2178-2186. doi: 10.2337/dc18-0777
Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A. and Hamilton-Williams, Emma E. (2018). Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome, 6 (1), 51. doi: 10.1186/s40168-018-0438-z
Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018). A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 (5) e98212. doi: 10.1172/jci.insight.98212
Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A. and Hamilton-Williams, Emma E. (2018). Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome, 6 (1) 35, 1-16. doi: 10.1186/s40168-018-0417-4
Brenu, Ekua W., Bartley, Timothy J., Wright, Casey M. and Hamilton-Williams, Emma E. (2017). CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes. Immunology and Cell Biology, 95 (9), 803-813. doi: 10.1038/icb.2017.49
Reeves, Peta L. S., Rudraraju, Rajeev, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice. European Journal of Immunology, 47 (9), 1550-1561. doi: 10.1002/eji.201747089
Reeves, Peta L. S., Rudraraju, Rajeev, Liu, Xiao, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice. Immunology and Cell Biology, 95 (9), 765-774. doi: 10.1038/icb.2017.48
Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009
James, Cini R., Buckle, Irina, Muscate, Franziska, Otsuka, Masayuki, Nakao, Mari, Oon, Jack S. H., Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2016). Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunology and Cell Biology, 94 (5), 509-519. doi: 10.1038/icb.2016.7
Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17
Hamilton-Williams, Emma E., Rainbow, Daniel B., Cheung, Jocelyn, Christensen, Mikkel, Lyons, Paul A., Peterson, Laurence B., Steward, Charles A., Sherman, Linda A. and Wicker, Linda S. (2013). Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mammalian Genome, 24 (9-10), 358-375. doi: 10.1007/s00335-013-9466-y
Lin, Xiaotian, Hamilton-Williams, Emma E., Rainbow, Daniel B., Hunter, Kara M., Dai, Yang D., Cheung, Jocelyn, Peterson, Laurence B., Wicker, Linda S. and Sherman, Linda A. (2013). Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. Journal of Immunology, 190 (7), 3109-3120. doi: 10.4049/jimmunol.1203422
Maine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S. and Sherman, Linda A. (2012). PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology, 188 (11), 5267-5275. doi: 10.4049/jimmunol.1200150
Hamilton-Williams, Emma E., Cheung, Jocelyn, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2012). Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes, 61 (1), 166-174. doi: 10.2337/db11-0790
Sheng, Huiming, Hassanali, Saleena, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma, Dias, Peter and Dai, Yang D. (2011). Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. Journal of Immunology, 187 (4), 1591-1600. doi: 10.4049/jimmunol.1100231
Hamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2010). Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells. Diabetes, 59 (6), 1478-1486. doi: 10.2337/db09-1801
Hamilton-Williams, Emma E., Martinez, Xavier, Clark, Jan, Howlett, Sarah, Hunter, Kara M., Rainbow, Daniel B., Wen, Li, Shlomchik, Mark J., Katz, Jonathan D., Beilhack, Georg F., Wicker, Linda S. and Sherman, Linda A. (2009). Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. Journal of Immunology, 183 (3), 1533-1541. doi: 10.4049/jimmunol.0900428
Heymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (7), 2114-2114. doi: 10.1172/JCI38399C1
Heymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (5), 1286-1297. doi: 10.1172/JCI38399
Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gotot, Janine and Kurts, Christian (2009). CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigens. European Journal of Immunology, 39 (1), 225-233. doi: 10.1002/eji.200838699
Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Kurts, Christian (2008). Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. Journal of Immunology, 181 (7), 4447-4451. doi: 10.4049/jimmunol.181.7.4447
Benke, Dirk, Kruger, Thilo, Lang, Andreas, Hamilton-Williams, Emma E. and Kurts, Christian (2006). Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens. Journal of Immunological Methods, 310 (1-2), 12-19. doi: 10.1016/j.jim.2005.10.019
Hamilton-Williams, Emma E., Lang, Andreas, Benke, Dirk, Davey, Gayle M., Wiesmuller, Karl-Heinz and Kurts, Christian (2005). Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens. Journal of Immunology, 174 (3), 1159-1163. doi: 10.4049/jimmunol.174.3.1159
Lang, Andreas, Benke, Dirk, Eitner, Frank, Engel, Daniel, Ehrlich, Svenja, Breloer, Minka, Hamilton-Williams, Emma, Specht, Sabine, Hoerauf, Achim, Floege, Jürgen, von Bonin, Arne and Kurts, Christian (2005). Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signal. Journal of the American Society of Nephrology, 16 (2), 383-391. doi: 10.1681/ASN.2004040276
Kruger, T, Benke, D, Eitner, F, Lang, A, Wirtz, M, Hamilton-Williams, EE, Engel, D, Giese, B, Muller-Newen, G, Floege, J and Kurts, C (2004). Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. Journal of the American Society of Nephrology, 15 (3), 613-621. doi: 10.1097/01.ASN.0000114553.36258.91
Hamilton-Williams, EE, Palmer, SE, Charlton, B and Slattery, RM (2003). Beta cell MHC class I is a late requirement for diabetes. Proceedings of the National Academy of Sciences of the United States of America, 100 (11), 6688-6693. doi: 10.1073/pnas.1131954100
Hanninen, A, Hamilton-Williams, E and Kurts, C (2003). Development of new strategies to prevent type diabetes: the role of animal models. Annals of Medicine, 35 (8), 546-563. doi: 10.1080/07853890310014597
Brandenburg, VM, Kurts, C, Eitner, F, Hamilton-Williams, E and Heintz, B (2002). Acute reversible renal failure in acute generalized exanthematous pustulosis. Nephrology Dialysis Transplantation, 17 (10), 1857-1858. doi: 10.1093/ndt/17.10.1857
Hamilton-Williams, EE, Serreze, DV, Charlton, B, Johnson, EA, Marron, MP, Mullbacher, A and Slattery, RM (2001). Transgenic rescue implicates beta(2)-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proceedings of the National Academy of Sciences of the United States of America, 98 (20), 11533-11538. doi: 10.1073/pnas.191383798
Conference Papers
Walker, G., Mallitt, K. -A., Sevendal, A., Ward, E., Caguicla, J., Naing, Z., Couper, J., Penno, M., Wentworth, J., Hamilton-Williams, E., Craig, M., Kim, K. W. and Rawlinson, W. (2024). No increased risk of islet autoimmunity following SARS-CoV-2 infection in ENDIA children. 50th Annual Conference of the International Society for Pediatric and Adolescent Diabetes (ISPAD), Lisbon, Portugal, 16-19 October 2024. Basel, Switzerland: S. Karger.
Bergot, A. S., Buckle,, Wright, C., Talekar, M., Hamilton-Williams, E. and Thomas, R. (2018). Antigen-Specific CD4 regulation by Liposomes encapsulating calcitriol and ChgA mimotope in NOD mice. 15th International Symposium on Dendritic Cells (DC), Aachen, Germany, 10-14 June 2018. Hoboken, NJ, United States: Wiley. doi: 10.1002/eji.201871000
Bergot, Anne-Sophie, Talekar, Meghna, Nel, Hanno, Galea, Ryan, Harris, Mark, Hamilton-Williams, Emma and Thomas, Ranjeny (2017). Antigen specific immunotherapy for autoimmune disease targeting dendritic cells. 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS), Kanazawa Japan, 29 October - 2 November 2017. London United Kingdom: Elsevier.
Buckle, I, Steptoe, R. J., Thomas, R. and Hamilton-Williams, E. E. (2016). Development of a model for antigen-specific tolerising immunotherapy and response in NOD mice. International Congress of Immunology (ICI 2016), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley.
Mullaney, J., Stephens, J. and Hamilton-Williams, E. (2016). Type 1 diabetes susceptibility genes impair gut physiology and lead to perturbations in the microbiota. International Congress of Immunology (ICI), Melbourne, Australia, Aug 21-26, 2016. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. doi: 10.1002/eji.201670200
Dai, Yang, Sheng, Huiming, Hassanali, Saleema, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma and Dias, Peter (2011). Exosome-like microparticles can stimulate both innate and adaptive autoimmunity in non-obese diabetes mice. AMER ASSOC IMMUNOLOGISTS.
Kurts, Christian, Ludwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Gotot, Janine (2009). Antigen-specific suppression of non-lymphoid tissue auto-antibody production by CD25(+) FoxP3(+) regulatory T cells. BETHESDA: AMER ASSOC IMMUNOLOGISTS.
Hamilton-Williams, Emma E., Martinez, Xavier, Hunter, Kara M., Rainbow, Dan, Wicker, Linda S. and Sherman, Linda A. (2009). Expression of the Diabetes Associated Alleles of ldd3 and ldd5 in DCs Drives Loss of Tolerance in NOD Mice. 9th Annual Meeting of the Federation-of-Clinical-Immunology-Societies, San Francisco Ca, Jun 11-14, 2009. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. doi: 10.1016/j.clim.2009.03.270
Hamilton-Williams, Emma, Martinez, Javier, Wong, Justin, Wicker, Linda and Sherman, Linda (2008). Restoration of CD8 self-tolerance in NOD mice by protective Idd9 genes. FEDERATION AMER SOC EXP BIOL.
Hamilton-Williams, E.E., Martinez, X., Lyman, M., Hunter, K., Wicker, L.S. and Sherman, L.A. (2007). The use of Idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen. Conference on How Do We Best Employ Animal Models for Type 1 Diabetes and Multiple Sclerosis, San Francisco, CA, United States, 8-9 November 2006. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1394.003
Kurts, C, Lang, A, Kruger, T, Benke, D, Hamilton-Williams, E, Wirtz, M, Ehrlich, S, von Bonin, A, Assmann, K, Eitner, F and Floege, J (2003). Release of heat shock protein 60 is an endogenous enhancer of nephrotoxic nephritis. 36th Annual Meeting of the American-Society-of-Nephrology, San Diego California, Nov 12-17, 2003. LIPPINCOTT WILLIAMS & WILKINS.