Associate Professor Arutha Kulasinghe

Kulasinghe, Arutha, Berrell, Naomi, Donovan, Meg L. and Nilges, Benedikt S. (2025). Spatial-Omics Methods and Applications. Methods in Molecular Biology. (pp. 101-146) New York, NY: Springer US. doi: 10.1007/978-1-0716-4276-4_5

Radfar, Payar, Es, Hamidreza Aboulkheyr, Kulasinghe, Arutha, Thiery, Jean Paul and Warkiani, Majid Ebrahimi (2023). Circulating tumour cell isolation and molecular profiling; potential therapeutic intervention. Circulating tumor cells. (pp. 359-385) edited by Richard J. Cote and Evi Lianidou. Cham, Switzerland: Springer. doi: 10.1007/978-3-031-22903-9_14

Müller Bark, Juliana, Kulasinghe, Arutha, Amenábar, José Miguel and Punyadeera, Chamindie (2021). Exosomes in cancer. Advances in Clinical Chemistry. (pp. 1-40) edited by Gregory S Makowski. San Diego, CA, United States: Academic Press. doi: 10.1016/bs.acc.2020.06.006

Azadi, Shohreh, Aboulkheyr Es, Hamidreza, Kulasinghe, Arutha, Bordhan, Pritam and Ebrahimi Warkiani, Majid (2020). Application of microfluidic technology in cancer research and therapy. Advances in Clinical Chemistry. (pp. 193-235) edited by Gregory S. Makowski. Cambridge, MA, United States: Academic Press. doi: 10.1016/bs.acc.2020.02.012

Kulasinghe, Arutha, Warkiani, Majid Ebrahimi and Punyadeera, Chamindie (2019). The isolation and characterization of circulating tumor cells from head and neck cancer patient blood samples using spiral microfluidic technology. Methods in Molecular Biology. (pp. 129-136) New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-9769-5_8

Kulasinghe, Arutha, Schmidt, Henri and Punyadeera, Chamindie (2016). Circulating tumor cells: isolation, expansion, characterization and translation to clinic. Circulating tumor cells (CTCs): detection methods, health impact and emerging clinical challenges. (pp. 1-18) edited by Paresh Chandra Ray. New York, NY United States: Nova Science Publishers, Inc..

Zhang, Xi, Kulasinghe, Arutha, Karim, Rafid Shahriyar and Punyadeera, Chamindie (2015). Saliva diagnostics for oral diseases. Advances in salivary diagnostics. (pp. 131-156) edited by Charles F. Streckfus. Berlin, Germany: Springer Berlin Heidelberg. doi: 10.1007/978-3-662-45399-5_7

Kulasinghe, Arutha, Lim, Yenkai, Perry, Chris F. L. and Punyadeera, Chamindie (2015). Current trends and management in head and neck cancers. Head and neck cancer: epidemiology, management, and treatment outcomes. (pp. 41-74) edited by Madison R. Hall. New York, NY United States: Nova Science Publishers.

Tan, Chin Wee, Berrell, Naomi, Donovan, Meg L., Monkman, James, Lawler, Clara, Sadeghirad, Habib, Naei, Vahid Yaghoubi, Chen, Jinjin, Rossenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Filanoski, Brian, Kang, Christine, Beechem, Joseph M., Fraser, John F., Barnett, Catherine, Ladwa, Rahul, Hughes, Brett G. M. and Kulasinghe, Arutha (2025). The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment. npj Precision Oncology, 9 (1) 191. doi: 10.1038/s41698-025-00963-0

Naei, Vahid Yaghoubi, Tubelleza, Rafael, Monkman, James, Sadeghirad, Habib, Donovan, Meg L., Blick, Tony, Wicher, Agata, Bodbin, Sara, Viratham, Amelie, Stad, Robert, Basu, Subham, Cooper, Caroline, Barnett, Catherine, O’Byrne, Ken, Ladwa, Rahul, Warkiani, Majid Ebrahimi, Hughes, Brett G. M. and Kulasinghe, Arutha (2025). Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response. Journal of Translational Medicine, 23 (1) 177, 177. doi: 10.1186/s12967-025-06186-y

Rouaen, Jourdin R. C., Salerno, Antonietta, Shai-Hee, Tyler, Murray, Jayne E., Castrogiovanni, Giulia, McHenry, Charlotte, Jue, Toni Rose, Pham, Vu, Bell, Jessica Lilian, Poursani, Ensieh, Valli, Emanuele, Cazzoli, Riccardo, Damstra, Naomi, Nelson, Delia J., Stevens, Kofi L. P., Chee, Jonathan, Slapetova, Iveta, Kasherman, Maria, Whan, Renee, Lin, Francis, Cochran, Blake J., Tedla, Nicodemus, Veli, Feyza Colakoglu, Yuksel, Aysen, Mayoh, Chelsea, Saletta, Federica, Mercatelli, Daniele, Chtanova, Tatyana, Kulasinghe, Arutha ... Vittorio, Orazio (2024). Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma. Nature Communications, 15 (1) 10462, 1-20. doi: 10.1038/s41467-024-54689-x

Berrell, Naomi, Monkman, James, Donovan, Meg, Blick, Tony, O'Byrne, Ken, Ladwa, Rahul, Tan, Chin Wee and Kulasinghe, Arutha (2024). Spatial resolution of the head and neck cancer tumor microenvironment to identify tumor and stromal features associated with therapy response. Immunology and Cell Biology, 102 (9), 830-846. doi: 10.1111/imcb.12811

Donovan, Meg L., Jhaveri, Niyati, Ma, Ning, Cheikh, Bassem Ben, DeRosa, James, Mihani, Ritu, Berrell, Naomi, Suen, Jacky Y., Monkman, James, Fraser, John F. and Kulasinghe, Arutha (2024). Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion. STAR Protocols, 5 (3) 103226, 1-18. doi: 10.1016/j.xpro.2024.103226

Zhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, 1-12. doi: 10.1002/advs.202401818

Menéndez, Victoria, Solórzano, José L., García-Cosío, Mónica, Cereceda, Laura, Díaz, Eva, Estévez, Mónica, Roncador, Giovanna, Vega, Zaira, Montalbán, Carlos, Kulasinghe, Arutha and García, Juan F. (2024). Mapping the spatial dynamics of the CD4+ T cell spectrum in classical Hodgkin lymphoma. Modern Pathology, 37 (9) 100551, 100551. doi: 10.1016/j.modpat.2024.100551

Sadeghirad, Habib, Monkman, James, Tan, Chin Wee, Liu, Ning, Yunis, Joseph, Donovan, Meg L., Moradi, Afshin, Jhaveri, Niyati, Perry, Chris, Adams, Mark N., O’Byrne, Ken, Warkiani, Majid E., Ladwa, Rahul, Hughes, Brett G.M. and Kulasinghe, Arutha (2024). Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response. Journal of Translational Medicine, 22 (1) 677, 677. doi: 10.1186/s12967-024-05409-y

Yaghoubi Naei, Vahid, Monkman, James, Sadeghirad, Habib, Mehdi, Ahmed, Blick, Tony, Mullally, William, O'Byrne, Ken, Warkiani, Majid Ebrahimi and Kulasinghe, Arutha (2024). Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survival. Clinical & Translational Immunology, 13 (7) e1522, e1522. doi: 10.1002/cti2.1522

Shanmugasundaram, Karthik B., Ahmed, Emtiaz, Miao, Xinzhe, Kulasinghe, Arutha, Fletcher, James A., Monkman, James, Mainwaring, Paul, Masud, Mostafa Kamal, Park, Hyeongyu, Hossain, Md Shahriar A., Yamauchi, Yusuke, Sina, Abu A. I., O’Byrne, Kenneth, Wuethrich, Alain and Trau, Matt (2024). A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue. ACS Sensors, 9 (6), 3009-3016. doi: 10.1021/acssensors.4c00192

Yaghoubi Naei, Vahid, Ivanova, Ekaterina, Mullally, William, O'Leary, Connor G, Ladwa, Rahul, O'Byrne, Ken, Warkiani, Majid E and Kulasinghe, Arutha (2024). Characterisation of circulating tumor‐associated and immune cells in patients with advanced‐stage non‐small cell lung cancer. Clinical and Translational Immunology, 13 (6) e1516, e1516. doi: 10.1002/cti2.1516

Sadeghirad, Habib, Yaghoubi Naei, Vahid, O’Byrne, Ken, Warkiani, Majid E and Kulasinghe, Arutha (2024). In situ characterization of the tumor microenvironment. Current Opinion in Biotechnology, 86 103083, 103083. doi: 10.1016/j.copbio.2024.103083

Monkman, James, Moradi, Afshin, Yunis, Joseph, Ivison, Geoff, Mayer, Aaron, Ladwa, Rahul, O’Byrne, Ken and Kulasinghe, Arutha (2024). Spatial insights into immunotherapy response in non-small cell lung cancer (NSCLC) by multiplexed tissue imaging. Journal of Translational Medicine, 22 (1) 239, 239. doi: 10.1186/s12967-024-05035-8

Davoudi, Fatemeh, Moradi, Afshin, Sadeghirad, Habib and Kulasinghe, Arutha (2024). Tissue biomarkers of immune checkpoint inhibitor therapy. Immunology and Cell Biology, 102 (3), 179-193. doi: 10.1111/imcb.12723

Orr, Miranda E., Kulasinghe, Arutha, Kolar, Grant R., Heyn, Holger, Plummer, Jasmine, Kristensen, Lasse Sommer, Kjems, Jorgen, Mills, Gordon, Garcia-Vallejo, Juan J., Nijman, I.J., West, Nicholas P. and Cox, Amanda (2024). Sounding an Alarm over Spatial Biology : Scientists from across the globe highlight spatial biology's triumphs and legal trials while issuing an urgent call for antitrust action. Genetic Engineering and Biotechnology News, 44 (3), 16-17. doi: 10.1089/gen.44.03.07

Wiegmans, A. P., Ivanova, E., Naei, V. Y., Monkman, J., Fletcher, J., Mullally, W., Warkiani, M. E., O’Byrne, K. and Kulasinghe, A. (2024). Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer. Clinical and Experimental Metastasis, 41 (2), 219-228. doi: 10.1007/s10585-024-10270-w

Carney, Meagan, Pelaia, Tiana Maria, Chew, Tracy, Teoh, Sally, Phu, Amy, Kim, Karan, Wang, Ya, Iredell, Jonathan, Zerbib, Yoann, McLean, Anthony, Schughart, Klaus, Tang, Benjamin, Shojaei, Maryam, Short, Kirsty R, PREDICT-19 consortium and Kulasinghe, Arutha (PREDICT-19 consortium member) (2024). Host transcriptomics and machine learning for secondary bacterial infections in patients with COVID-19: a prospective, observational cohort study. The Lancet Microbe, 5 (3), e272-e281. doi: 10.1016/S2666-5247(23)00363-4

Ravichandran, Akhilandeshwari, Monkman, James, Mehdi, Ahmed M., Blick, Tony, Snell, Cameron, Kulasinghe, Arutha and Bray, Laura J. (2024). The in situ transcriptomic landscape of breast tumour-associated and normal adjacent endothelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870 (2) 166985, 166985. doi: 10.1016/j.bbadis.2023.166985

Tu, Cui, Kulasinghe, Arutha, Barbour, Andrew and Souza-Fonseca-Guimaraes, Fernando (2024). Leveraging spatial omics for the development of precision sarcoma treatments. Trends in Pharmacological Sciences, 45 (2), 134-144. doi: 10.1016/j.tips.2023.12.006

Liu, Ning, Bhuva, Dharmesh D, Mohamed, Ahmed, Bokelund, Micah, Kulasinghe, Arutha, Tan, Chin Wee and Davis, Melissa J (2024). standR: spatial transcriptomic analysis for GeoMx DSP data. Nucleic Acids Research, 52 (1) e2, 1-11. doi: 10.1093/nar/gkad1026

Shah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2024). Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells. British Journal of Cancer, 130 (7), 1196-1205. doi: 10.1038/s41416-024-02584-z

Berrell, Naomi, Sadeghirad, Habib, Blick, Tony, Bidgood, Charles, Leggatt, Graham R., O'Byrne, Ken and Kulasinghe, Arutha (2023). Metabolomics at the tumor microenvironment interface: decoding cellular conversations. Medicinal Research Reviews, 44 (3), 1121-1146. doi: 10.1002/med.22010

Kulasinghe, A., Monkman, J., Moradi, A., Yunis, J., Ivison, G., Mayer, A. and O'Byrne, K. (2023). MA09.03 High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer. Journal of Thoracic Oncology, 18 (11), S129-s129. doi: 10.1016/j.jtho.2023.09.173

Nair, Soumyalekshmi, Nova-Lamperti, Estefania, Labarca, Gonzalo, Kulasinghe, Arutha, Short, Kirsty R., Carrión, Flavio and Salomon, Carlos (2023). Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19. Journal of Translational Medicine, 21 (1) 709, 1-19. doi: 10.1186/s12967-023-04552-2

Kulasinghe, Arutha, Wood, Fiona and Belz, Gabrielle (2023). The seductive allure of spatial biology: accelerating new discoveries in the life sciences. Immunology and Cell Biology, 101 (9), 798-804. doi: 10.1111/imcb.12669

Jhaveri, Niyati, Ben Cheikh, Bassem, Nikulina, Nadezhda, Ma, Ning, Klymyshyn, Dmytro, DeRosa, James, Mihani, Ritu, Pratapa, Aditya, Kassim, Yasmin, Bommakanti, Sidharth, Shang, Olive, Berry, Shannon, Ihley, Nicholas, McLane, Michael, He, Yan, Zheng, Yi, Monkman, James, Cooper, Caroline, O'Byrne, Ken, Anand, Bhaskar, Prater, Michael, Basu, Subham, Hughes, Brett G. M., Kulasinghe, Arutha and Braubach, Oliver (2023). Mapping the spatial proteome of head and neck tumors: key immune mediators and metabolic determinants in the tumor microenvironment. GEN Biotechnology, 2 (5), 418-434. doi: 10.1089/genbio.2023.0029

Yaghoubi Naei, Vahid, Bordhan, Pritam, Mirakhorli, Fatemeh, Khorrami, Motahare, Shrestha, Jesus, Nazari, Hojjatollah, Kulasinghe, Arutha and Ebrahimi Warkiani, Majid (2023). Advances in novel strategies for isolation, characterization, and analysis of CTCs and ctDNA. Therapeutic Advances in Medical Oncology, 15 17588359231192401, 1-40. doi: 10.1177/17588359231192401

Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Matigian, Nicholas, Cumberbatch, Marie, Bhagat, Milan, Ladwa, Rahul, Mueller, Scott N., Adams, Mark N., O'Byrne, Ken and Kulasinghe, Arutha (2023). Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer. Immunology, 169 (4), 487-502. doi: 10.1111/imm.13646

Kulasinghe, Arutha (2023). Mapping immunotherapy sensitivity with multiomic approaches. Immuno Oncology Insights, 4 (6), 235-237. doi: 10.18609/ioi.2023.031

Ahmed, Mostak, Wuethrich, Alain, Constantin, Nicolas, Shanmugasundaram, Karthik Balaji, Mainwaring, Paul, Kulasinghe, Arutha, O’Leary, Connor, O’Byrne, Ken, Sina, Abu Ali Ibn, Carrascosa, Laura G. and Trau, Matt (2023). Liquid biopsy snapshots of key phosphoproteomic pathways in lung cancer patients for diagnosis and therapy monitoring. Analytical Chemistry, 95 (22), 8522-8532. doi: 10.1021/acs.analchem.3c00519

Sadeghirad, Habib, Liu, Ning, Monkman, James, Ma, Ning, Cheikh, Bassem Ben, Jhaveri, Niyati, Tan, Chin Wee, Warkiani, Majid Ebrahimi, Adams, Mark N., Nguyen, Quan, Ladwa, Rahul, Braubach, Oliver, O’Byrne, Ken, Davis, Melissa, Hughes, Brett G. M. and Kulasinghe, Arutha (2023). Compartmentalized spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma identifies immune checkpoint molecules and tumor necrosis factor receptor superfamily members as biomarkers of response to immunotherapy. Frontiers in Immunology, 14 1135489, 1-16. doi: 10.3389/fimmu.2023.1135489

Wang, Ya, Schughart, Klaus, Pelaia, Tiana Maria, Chew, Tracy, Kim, Karan, Karvunidis, Thomas, Knippenberg, Ben, Teoh, Sally, Phu, Amy L., Short, Kirsty R., Iredell, Jonathan, Thevarajan, Irani, Audsley, Jennifer, Macdonald, Stephen, Burcham, Jonathon, McLean, Anthony, Tang, Benjamin, Shojaei, Maryam, PREDICT-19 consortium, Kulasinghe, Arutha and Carney, Meagan E. (2023). Blood transcriptome responses in patients correlate with severity of COVID-19 disease. Frontiers in Immunology, 13 1043219, 1-18. doi: 10.3389/fimmu.2022.1043219

Shojaei, Maryam, Shamshirian, Amir, Monkman, James, Grice, Laura, Tran, Minh, Tan, Chin Wee, Teo, Siok Min, Rodrigues Rossi, Gustavo, McCulloch, Timothy R., Nalos, Marek, Raei, Maedeh, Razavi, Alireza, Ghasemian, Roya, Gheibi, Mobina, Roozbeh, Fatemeh, Sly, Peter D., Spann, Kirsten M., Chew, Keng Yih, Zhu, Yanshan, Xia, Yao, Wells, Timothy J., Senegaglia, Alexandra Cristina, Kuniyoshi, Carmen Lúcia, Franck, Claudio Luciano, dos Santos, Anna Flavia Ribeiro, Noronha, Lucia de, Motamen, Sepideh, Valadan, Reza, Amjadi, Omolbanin ... Tang, Benjamin (2023). IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study. Frontiers in Immunology, 13 1060438, 1-14. doi: 10.3389/fimmu.2022.1060438

Radfar, Payar, Aboulkheyr Es, Hamidreza, Salomon, Rob, Kulasinghe, Arutha, Ramalingam, Naveen, Sarafraz-Yazdi, Ehsan, Thiery, Jean Paul and Warkiani, Majid Ebrahimi (2022). Single-cell analysis of circulating tumour cells: enabling technologies and clinical applications. Trends in Biotechnology, 40 (9), 1041-1060. doi: 10.1016/j.tibtech.2022.02.004

Sadeghi Rad, Habib, Bahrami, Tayyeb, Layeghi, Sepideh Mehrpour, Yousefi, Hassan, Rezaei, Meysam, Hosseini‐Fard, Seyed Reza, Radfar, Payar, Warkiani, Majid Ebrahimi, O’Byrne, Ken and Kulasinghe, Arutha (2022). Immunotherapeutic targets in non‐small cell lung cancer. Immunology, 168 (2), 1-17. doi: 10.1111/imm.13562

Tran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13 911873, 911873. doi: 10.3389/fimmu.2022.911873

Sadeghirad, Habib, Monkman, James, Mehdi, Ahmed M., Ladwa, Rahul, O’Byrne, Ken, Hughes, Brett G. M. and Kulasinghe, Arutha (2022). Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell Carcinomas. Frontiers in Immunology, 13 895513, 1-11. doi: 10.3389/fimmu.2022.895513

Shiravand, Yavar, Khodadadi, Faezeh, Kashani, Seyyed Mohammad Amin, Hosseini-Fard, Seyed Reza, Hosseini, Shadi, Sadeghirad, Habib, Ladwa, Rahul, O’Byrne, Ken and Kulasinghe, Arutha (2022). Immune checkpoint inhibitors in cancer therapy. Current Oncology, 29 (5), 3044-3060. doi: 10.3390/curroncol29050247

Kapeleris, Joanna, Ebrahimi Warkiani, Majid, Kulasinghe, Arutha, Vela, Ian, Kenny, Liz, Ladwa, Rahul, O’Byrne, Kenneth and Punyadeera, Chamindie (2022). Clinical applications of circulating tumour cells and circulating tumour dna in non-small cell lung cancer—an update. Frontiers in Oncology, 12 859152, 1-18. doi: 10.3389/fonc.2022.859152

Herath, Sayuri, Sadeghi Rad, Habib, Radfar, Payar, Ladwa, Rahul, Warkiani, Majid, O’Byrne, Ken and Kulasinghe, Arutha (2022). The role of circulating biomarkers in lung cancer. Frontiers in Oncology, 11 801269, 1-13. doi: 10.3389/fonc.2021.801269

Kulasinghe, Arutha, Monkman, James, Shah, Esha T., Matigian, Nicholas, Adams, Mark N. and O’Byrne, Ken (2022). Spatial profiling identifies prognostic features of response to adjuvant therapy in Triple Negative Breast Cancer (TNBC). Frontiers in Oncology, 11 798296, 798296. doi: 10.3389/fonc.2021.798296

Mackenzie, Nathan J, Nicholls, Clarissa, Templeton, Abby R, Perera, Mahasha PJ, Jeffery, Penny L, Zimmermann, Kate, Kulasinghe, Arutha, Kenna, Tony J, Vela, Ian, Williams, Elizabeth D and Thomas, Patrick B (2022). Modelling the tumor immune microenvironment for precision immunotherapy. Clinical and Translational Immunology, 11 (6) e1400, 1-22. doi: 10.1002/cti2.1400

Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S F, Clifton, Vicki L. and Kulasinghe, Arutha (2022). Corrigendum: The effects of COVID-19 on the placenta during pregnancy. Frontiers in immunology, 13 998406, 998406. doi: 10.3389/fimmu.2022.998406

Rad, Habib Sadeghi, Shiravand, Yavar, Radfar, Payar, Ladwa, Rahul, Perry, Chris, Han, Xiaoyuan, Warkiani, Majid Ebrahimi, Adams, Mark N., Hughes, Brett G.M., O'Byrne, Ken and Kulasinghe, Arutha (2022). Understanding the tumor microenvironment in head and neck squamous cell carcinoma. Clinical & Translational Immunology, 11 (6) e1397, e1397. doi: 10.1002/cti2.1397

Kulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021

Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350

Karimi, Amirali, Shobeiri, Parnian, Kulasinghe, Arutha and Rezaei, Nima (2021). Novel systemic inflammation markers to predict COVID-19 prognosis. Frontiers in Immunology, 12 741061. doi: 10.3389/fimmu.2021.741061

Yekelchyk, Michail, Madan, Esha, Wilhelm, Jochen, Short, Kirsty R, Palma, António M, Liao, Linbu, Camacho, Denise, Nkadori, Everlyne, Winters, Michael T, Rice, Emily S, Rolim, Inês, Cruz‐Duarte, Raquel, Pelham, Christopher J, Nagane, Masaki, Gupta, Kartik, Chaudhary, Sahil, Braun, Thomas, Pillappa, Raghavendra, Parker, Mark S, Menter, Thomas, Matter, Matthias, Haslbauer, Jasmin Dionne, Tolnay, Markus, Galior, Kornelia D, Matkwoskyj, Kristina A, McGregor, Stephanie M, Muller, Laura K, Rakha, Emad A, Lopez‐Beltran, Antonio ... Gogna, Rajan (2021). Flower lose, a cell fitness marker, predicts COVID‐19 prognosis. EMBO Molecular Medicine, 13 (11) e13714, e13714. doi: 10.15252/emmm.202013714

Kulasinghe, Arutha, O'Leary, Connor, Monkman, James, Bharti, Vandhana, Irwin, Darryl, Dutta, Sanjay, Richard, Derek J., Hughes, Brett, Ladwa, Rahul and O'Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). Lung Cancer, 160, 73-77. doi: 10.1016/j.lungcan.2021.08.005

Rad, Habib Sadeghi, Röhl, Joan, Stylianou, Nataly, Allenby, Mark C., Bazaz, Sajad Razavi, Warkiani, Majid E., Guimaraes, Fernando S. F., Clifton, Vicki L. and Kulasinghe, Arutha (2021). The effects of COVID-19 on the placenta during pregnancy. Frontiers in Immunology, 12 743022. doi: 10.3389/fimmu.2021.743022

Sato, Kei, Sinclair, Jane E., Sadeghirad, Habib, Fraser, John F., Short, Kirsty R. and Kulasinghe, Arutha (2021). Cardiovascular disease in SARS‐CoV‐2 infection. Clinical and Translational Immunology, 10 (9) e1343, e1343. doi: 10.1002/cti2.1343

Rad, Habib Sadeghi, Rad, Hamid Sadeghi, Shiravand, Yavar, Radfar, Payar, Arpon, David, Warkiani, Majid Ebrahimi, O'Byrne, Ken and Kulasinghe, Arutha (2021). The Pandora’s box of novel technologies that may revolutionize lung cancer. Lung Cancer, 159, 34-41. doi: 10.1016/j.lungcan.2021.06.022

Rzhevskiy, Alexey, Kapitannikova, Alina, Malinina, Polina, Volovetsky, Arthur, Aboulkheyr Es, Hamidreza, Kulasinghe, Arutha, Thiery, Jean Paul, Maslennikova, Anna, Zvyagin, Andrei V. and Ebrahimi Warkiani, Majid (2021). Emerging role of circulating tumor cells in immunotherapy. Theranostics, 11 (16), 8057-8075. doi: 10.7150/thno.59677

Müller Bark, Juliana, Kulasinghe, Arutha, Hartel, Gunter, Leo, Paul, Warkiani, Majid Ebrahimi, Jeffree, Rosalind L., Chua, Benjamin, Day, Bryan W. and Punyadeera, Chamindie (2021). Isolation of circulating tumour cells in patients with glioblastoma using spiral microfluidic technology – a pilot study. Frontiers in Oncology, 11 681130, 681130. doi: 10.3389/fonc.2021.681130

Sadeghi Rad, Habib, Monkman, James, Warkiani, Majid E., Ladwa, Rahul, O'Byrne, Ken, Rezaei, Nima and Kulasinghe, Arutha (2021). Understanding the tumor microenvironment for effective immunotherapy. Medicinal Research Reviews, 41 (3), 1474-1498. doi: 10.1002/med.21765

Kalita-de Croft, Priyakshi, Rad, Habib Sadeghi, Gasper, Harry, O'Byrne, Ken, Lakhani, Sunil R. and Kulasinghe, Arutha (2021). Spatial profiling technologies and applications for brain cancers. Expert Review of Molecular Diagnostics, 21 (3), 323-332. doi: 10.1080/14737159.2021.1900735

Kulasinghe, Arutha, Taheri, Touraj, O'Byrne, Ken, Hughes, Brett G. M., Kenny, Liz and Punyadeera, Chamindie (2021). Highly multiplexed digital spatial profiling of the tumor microenvironment of head and neck squamous cell carcinoma patients. Frontiers in Oncology, 10 607349, 607349. doi: 10.3389/fonc.2020.607349

Rasheduzzaman, Mohammad, Kulasinghe, Arutha, Dolcetti, Riccardo, Kenny, Liz, Johnson, Newell W., Kolarich, Daniel and Punyadeera, Chamindie (2020). Protein glycosylation in head and neck cancers: From diagnosis to treatment. Biochimica et Biophysica Acta - Reviews on Cancer, 1874 (2) 188422. doi: 10.1016/j.bbcan.2020.188422

Monkman, James, Taheri, Touraj, Warkiani, Majid Ebrahimi, O’Leary, Connor, Ladwa, Rahul, Richard, Derek, O’ Byrne, Ken and Kulasinghe, Arutha (2020). High-plex and high-throughput digital spatial profiling of non-small-cell lung cancer (NSCLC). Cancers, 12 (12) 3551, 1-16. doi: 10.3390/cancers12123551

Kulasinghe, Arutha, Monkman, James, Nalder, Mark, O’Leary, Connor, Ladwa, Rahul and O’Byrne, Ken (2020). Transformation or progression from adenocarcinoma to small cell lung cancer detected by serially tracking mutations in the blood. Reports, 3 (4) 33, 33. doi: 10.3390/reports3040033

Herath, Sayuri, Razavi Bazaz, Sajad, Monkman, James, Ebrahimi Warkiani, Majid, Richard, Derek, O’Byrne, Ken and Kulasinghe, Arutha (2020). Circulating tumor cell clusters: insights into tumour dissemination and metastasis. Expert Review of Molecular Diagnostics, 20 (11), 1139-1147. doi: 10.1080/14737159.2020.1846523

Hanaei, Sara, Takian, Amirhossein, Majdzadeh, Reza, Maboloc, Christopher Ryan, Grossmann, Igor, Gomes, Orlando, Milosevic, Milos, Gupta, Manoj, Shamshirsaz, Alireza A., Harbi, Amine, Burhan, Amer M., Uddin, Lucina Q., Kulasinghe, Arutha, Lam, Chi-Ming, Ramakrishna, Seeram, Alavi, Abass, Nouwen, Jan L., Dorigo, Tommaso, Schreiber, Michael, Abraham, Ajith, Shelkovaya, Natalya, Krysztofiak, Wojtek, Ebrahimi Warkiani, Majid, Sellke, Frank, Ogino, Shuji, Barba, Francisco J., Brand, Serge, Vasconcelos, Clara, Salunke, Deepak B. and Rezaei, Nima (2020). Emerging standards and the hybrid model for organizing scientific events during and after the COVID-19 pandemic. Disaster Medicine and Public Health Preparedness, 16 (3) PII S1935789320004061, 1-6. doi: 10.1017/dmp.2020.406

O’Leary, Connor, Gasper, Harry, Sahin, Katherine B., Tang, Ming, Kulasinghe, Arutha, Adams, Mark N., Richard, Derek J. and O’Byrne, Ken J. (2020). Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). Pharmaceuticals, 13 (10) 273, 1-16. doi: 10.3390/ph13100273

Kapeleris, Joanna, Kulasinghe, Arutha, Warkiani, Majid Ebrahimi, Oleary, Connor, Vela, Ian, Leo, Paul, Sternes, Peter, O'Byrne, Kenneth and Punyadeera, Chamindie (2020). Ex vivo culture of circulating tumour cells derived from non-small cell lung cancer. Translational Lung Cancer Research, 9 (5), 1795-1809. doi: 10.21037/tlcr-20-521

Kulasinghe, Arutha, Lim, Yenkai, Kapeleris, Joanna, Warkiani, Majid, O'Byrne, Ken and Punyadeera, Chamindie (2020). The use of three-dimensional DNA fluorescent in situ hybridization (3D DNA FISH) for the detection of Anaplastic Lymphoma Kinase (ALK) in Non-Small Cell Lung Cancer (NSCLC) circulating tumor cells. Cells, 9 (6) 1465, 1-8. doi: 10.3390/cells9061465

Müller Bark, Juliana, Kulasinghe, Arutha, Chua, Benjamin, Day, Bryan W. and Punyadeera, Chamindie (2020). Circulating biomarkers in patients with glioblastoma. British Journal of Cancer, 122 (3), 295-305. doi: 10.1038/s41416-019-0603-6

Sadeghi Rad, Habib, Bazaz, Sajad Razavi, Monkman, James, Ebrahimi Warkiani, Majid, Rezaei, Nima, O'Byrne, Ken and Kulasinghe, Arutha (2020). The evolving landscape of predictive biomarkers in immuno-oncology with a focus on spatial technologies. Clinical and Translational Immunology, 9 (11) e1215, 1-12. doi: 10.1002/cti2.1215

Zhou, Jian, Kulasinghe, Arutha, Bogseth, Amanda, O’Byrne, Ken, Punyadeera, Chamindie and Papautsky, Ian (2019). Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel. Microsystems and Nanoengineering, 5 (1) 8, 8. doi: 10.1038/s41378-019-0045-6

Kulasinghe, Arutha, Hughes, Brett G. M., Kenny, Liz and Punyadeera, Chamindie (2019). An update: circulating tumor cells in head and neck cancer. Expert Review of Molecular Diagnostics, 19 (12), 1109-1115. doi: 10.1080/14737159.2020.1688145

Kulasinghe, Arutha, Kapeleris, Joanna, Cooper, Carolina, Warkiani, Majid Ebrahimi, O’Byrne, Kenneth and Punyadeera, Chamindie (2019). Phenotypic characterization of circulating lung cancer cells for clinically actionable targets. Cancers, 11 (3) 380, 380. doi: 10.3390/cancers11030380

Kulasinghe, Arutha, Zhou, Jian, Kenny, Liz, Papautsky, Ian and Punyadeera, Chamindie (2019). Capture of circulating tumour cell clusters using straight microfluidic chips. Cancers, 11 (1) 89, 89. doi: 10.3390/cancers11010089

Kulasinghe, Arutha, Schmidt, Henri, Perry, Chris, Whitfield, Bernard, Kenny, Liz, Nelson, Colleen, Warkiani, Majid E. and Punyadeera, Chamindie (2018). A collective route to head and neck cancer metastasis. Scientific Reports, 8 (1) 746, 1-8. doi: 10.1038/s41598-017-19117-9

Kulasinghe, Arutha, Kapeleris, Joanna, Kimberley, Rebecca, Mattarollo, Stephen R., Thompson, Erik W., Thiery, Jean-Paul, Kenny, Liz, O’Byrne, Ken and Punyadeera, Chamindie (2018). The prognostic significance of circulating tumor cells in head and neck and non-small-cell lung cancer. Cancer Medicine, 7 (12), 5910-5919. doi: 10.1002/cam4.1832

Schmidt, Henri, Kulasinghe, Arutha, Allcock, Richard J. N., Tan, Lit Yeen, Mokany, Elisa, Kenny, Liz and Punyadeera, Chamindie (2018). A pilot study to non-invasively track PIK3CA mutation in head and neck cancer. Diagnostics, 8 (4) 79, 79. doi: 10.3390/diagnostics8040079

Kapeleris, Joanna, Kulasinghe, Arutha, Warkiani, Majid E., Vela, Ian, Kenny, Liz, O' Byrne, Kenneth and Punyadeera, Chamindie (2018). The prognostic role of circulating tumor cells (CTCs) in lung cancer. Frontiers in Oncology, 8 (AUG) 311, 311. doi: 10.3389/fonc.2018.00311

Kulasinghe, Arutha, Wu, Hanjie, Punyadeera, Chamindie and Warkiani, Majid Ebrahimi (2018). The use of microfluidic technology for cancer applications and liquid biopsy. Micromachines, 9 (8) 397, 1-22. doi: 10.3390/mi9080397

Kulasinghe, Arutha, Kenny, Liz and Punyadeera, Chamindie (2017). Circulating tumour cell PD-L1 test for head and neck cancers. Oral Oncology, 75, 6-7. doi: 10.1016/j.oraloncology.2017.10.011

Kulasinghe, Arutha, Perry, Chris, Kenny, Liz, Warkiani, Majid E., Nelson, Colleen and Punyadeera, Chamindie (2017). PD-L1 expressing circulating tumour cells in head and neck cancers. BMC Cancer, 17 (1) 333, 333. doi: 10.1186/s12885-017-3316-3

Kulasinghe, Arutha, Tran, Thao Huynh Phuoc, Blick, Tony, O'Byrne, Ken, Thompson, Erik W., Warkiani, Majid E., Nelson, Colleen, Kenny, Liz and Punyadeera, Chamindie (2017). Enrichment of circulating head and neck tumour cells using spiral microfluidic technology. Scientific Reports, 7 (1) 42517, 42517. doi: 10.1038/srep42517

Schmidt, Henri, Kulasinghe, Arutha, Kenny, Liz and Punyadeera, Chamindie (2016). The development of a liquid biopsy for head and neck cancers. Oral Oncology, 61, 8-11. doi: 10.1016/j.oraloncology.2016.07.014

Kulasinghe, Arutha, Kenny, Liz, Perry, Chris, Thiery, Jean-Paul, Jovanovic, Lidija, Vela, Ian, Nelson, Colleen and Punyadeera, Chamindie (2016). Impact of label-free technologies in head and neck cancer circulating tumour cells. Oncotarget, 7 (44), 71223-71234. doi: 10.18632/oncotarget.12086

Schmidt, Henri, Kulasinghe, Arutha, Perry, Chris, Nelson, Colleen and Punyadeera, Chamindie (2016). A liquid biopsy for head and neck cancers. Expert Review of Molecular Diagnostics, 16 (2), 165-172. doi: 10.1586/14737159.2016.1127758

Kulasinghe, Arutha, Perry, Chris, Boyle, Glen M., O'Byrne, Ken, Davies, Anthony, Jovanovic, Lidija, Nelson, Colleen and Punyadeera, Chamindie (2016). Epithelial-mesenchymal axis in head and neck cancer cell lines. Journal of Solid Tumors, 6 (1). doi: 10.5430/jst.v6n1p28

Kulasinghe, Arutha, Perry, Chris, Warkiani, Majid E., Blick, Tony, Davies, Anthony, O'Byrne, Ken, Thompson, Erik W., Nelson, Colleen C., Vela, Ian and Punyadeera, Chamindie (2016). Short term ex-vivo expansion of circulating head and neck tumour cells. Oncotarget, 7 (37), 60101-60109. doi: 10.18632/oncotarget.11159

Kulasinghe, Arutha, Perry, Chris, Jovanovic, Lidija, Nelson, Colleen and Chamindie Punyadeera, (2015). Circulating tumour cells in metastatic head and neck cancers. International Journal of Cancer, 136 (11), 2515-2523. doi: 10.1002/ijc.29108

Markovits, Ettai, Monkman, James, Kilgallon, Aaron, Aung, Thazin Nwe, Rimm, David and Kulasinghe, Arutha (2025). Tumor microenvironment profiling of multiplexed images in head and neck cancer reveals spatial features associated with immunotherapy response. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-156

Monkman, James, Tan, Chin Wee, Tubelleza, Rafael, OByrne, Ken and Kulasinghe, Arutha (2025). Spatial deconvolution of non-small-cell lung cancer tissues prior to immune checkpoint inhibitor therapy. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-2082

Falkenstein, Brian, Yan, Raymond, Quinn, Shannon, Tosun, Akif Burak, Chennubhotla, S. Chakra, Kulasinghe, Arutha and Pullara, Filippo (2025). A Bayesian framework for unraveling disease biology from spatially resolved single-cell omics datasets by combining unbiased approaches with biological priors for cell-based microdomain discovery. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-2485

Tan, Chin Wee, Berrell, Naomi, Donovan, Meg L., Monkman, James, Sadeghirad, Habib, Naei, Vahid Yaghoubi, Chen, Jinjin, Rossenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Filanoski, Brian, Kang, Christine, Beechem, Joseph M., Fraser, John F., Barnett, Catherine, Ladwa, Rahul, Hughes, Brett G. and Kulasinghe, Arutha (2025). Characterising head and neck tumour microenvironment using high plex spatial omics technologies and analyses. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-175

Naei, Vahid Yaghoubi, Tubelleza, Rafael, Monkman, James, Sadeghirad, Habib, Donovan, Meg L., Blick, Tony, Wicher, Agata, Bodbin, Sara, Basu, Subham, Stad, Robert, Barnett, Catherine, O’Byrne, Ken, Ladwa, Rahul, Cooper, Caroline, Warkiani, Majid Ebrahimi, Hughes, Brett G.M. and Kulasinghe, Arutha (2025). Exploring PD1/PDL1 interactions and macrophage-tumor barriers in head and neck cancer: A spatial approach to immunotherapy response. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-750

Tu, Cui, Tan, Chin Wee, Monkman, James, Almeida, Ana Clara, Antonio-Carreon, Gabrielle, Omer, Natacha, Hull, Giaan, Chung, Kimberly, Mehdi, Ahmed, Salerno, Antonietta, Vittorio, Orazio, Mayer, Aaron, Machado de Souza, Cleber, de Almeida Brehm Pinhati, Fernanda, Elifio-Esposito, Selene, Nicholls, Wayne, de Noronha, Lucia, Kulasinghe, Arutha and Souza-Fonseca-Guimaraes, Fernando (2025). Spatial profiling of tumor microenvironment uncovers potential novel therapeutic approach in pediatric neuroblastoma. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-2705

Donovan, Meg L., Sadeghirad, Habib, Berrell, Naomi, Monkman, James, Naei, Vahid Yaghoubi, Tan, Chin Wee, Yunis, Joseph, West, Zoe, Warkiani, Majid E., Ladwa, Rahul, Hughes, Brett G., Da Gama Duarte, Jessica and Kulasinghe, Arutha (2025). 2D and 3D spatial characterisation of tertiary lymphoid structures in head and neck cancer patients receiving immune checkpoint blockade therapy. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-5252

Belle, Clemence J., Brosda, Sandra, Bonazzi, Vanessa F., Bulteau, Victor, Stuart, Thomas, Xiong, Zherui, Lambie, Duncan, Johansson, Peter A., Aoude, Lauren G., Patel, Kalpana, Stehbens, Samantha J., Stark, Mitchell S., Haass, Nikolas K., Xu, Wen, Pinkham, Mark B., Foote, Matthew C., Olson, Sarah, Atkinson, Victoria, Kulasinghe, Arutha, Nguyen, Quan H. and Barbour, Andrew (2025). Unravelling melanoma brain metastasis tumor microenvironment characteristics using spatial transcriptomics. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-5076

Naei, Vahid Yaghoubi, Monkman, James, Hughes, Brett and Kulasinghe, Arutha (2024). An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0558

Yan, Raymond, Quinn, Shannon, Falkenstein, Brian, Monkman, James, O’Bryne, Kenneth, Chakra Chennubhotla, S, Pullara, Filippo and Kulasinghe, Arutha (2024). Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patients. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0212

Kulasinghe, Arutha (2024). Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy response. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0110

Markovits, Ettai, Monkman, James, Aung, Thazin, Reeves, Jason, O’Byrne, Ken, Czertock, Rotem, Puig, Oscar, Rimm, David and Kulasinghe, Arutha (2024). Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patients. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0109

Kulasinghe, A., Monkman, J., Markovits, E. and O'Byrne, K. (2024). Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic Mapping. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.032

Yaghoubi Naei, V., Mullally, W., Warkiani, M., O'Byrne, K. and Kulasinghe, A. (2024). Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLC. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.473

Kulasinghe, A., Monkman, J. and O'Byrne, K.J. (2024). Multiomic spatial profiling of whole-slide NSCLC tissues from patients receiving anti PD-1 therapy identifies metabolic phenotypes associated with therapy resistance. ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.2037

Kulasinghe, A., Yan, R., Quinn, S., Falkenstein, B., Monkman, J., O'Byrne, K.J., Chennubhotla, S.C. and Pullara, F. (2024). Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC). ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.142

Monkman, James, Czertok, Rotem, Bookstein, Shai, Arbiv, Becky, Shachaf, Yuval, Elran, Ron, Bloom, Kenneth, Puig, Oscar, O'Byrne, Ken, Markovits, Ettai and Kulasinghe, Arutha (2024). Spatially resolved cell profiling unveils tumor metabolic states associated with immunotherapy response in NSCLC. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1158

Bodbin, Sara, Ma, Ning, Pratapa, Aditya, Nikulina, Nadya, Monkman, James, Jhaveri, Niyati, Elofsson, Hampus, Basu, Subham, Zieba-Wicher, Agata and Kulasinghe, Arutha (2024). Integration of high-plex tumor-Immune phenotyping and checkpoint interactions for deeper spatial characterization of human cancer tissues. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1525

Jhaveri, Niyati, Ben Cheikh, Bassem, Klymyshyn, Dmytro, Ma, Ning, Pratapa, Aditya, Monkman, James, Nelson, Nadine and Kulasinghe, Arutha (2024). A spatio-temporal approach to mapping the dynamics of cutaneous squamous cell carcinoma progression and immunotherapy response: A journey through TiME. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-6872

Sadeghirad, Habib, Tan, Chin Wee, Liu, Ning, Monkman, James, Cooper, Caroline, O’Byrne, Ken, Davis, Melissa, Hughes, Brett and Kulasinghe, Arutha (2024). Spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma revealed immune cell type infiltration into the TME as a predictor of immunotherapy response. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1154

Tu, Cui, Tan, Chin Wee, Liu, Ning, Kulasinghe, Arutha and Souza-Fonseca-Guimaraes, Fernando (2024). Spatial profiling of pediatric rhabdomyosarcoma to elucidate their immunosuppressive tumor microenvironment. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-73

Sadeghirad, Habib, Naei, Vahid Yaghoubi, Monkman, James, Basu, Subham, Wicher, Agata, Ladwa, Rahul, Hughes, Brett G.M. and Kulasinghe, Arutha (2024). Defining PD-1/PD-L1 receptor-ligand interactions in the head and neck cancer tumor microenvironment identifies unique ‘immune cell rivers’ of cellular interactions. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-5188

Pratapa, Aditya, Hernandez, Lydia, Cheikh, Bassem Ben, Jhaveri, Niyati and Kulasinghe, Arutha (2024). Ultrahigh-plex spatial phenotyping of head and neck cancer tissue uncovers multiomic signatures of immunotherapy response. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-5503

Aung, Thazin N., Moutafi, Myrto, Trontzas, Ioannis, Kulasinghe, Arutha, Monkman, James, Gavrielatou, Niki, Vathiotis, Ioannis, Warrell, Jonathan H. and Rimm, David L. (2024). Spatial-specific gene signatures to predict immunotherapy outcomes in lung cancer. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1141

O'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432

Kulasinghe, A., Monkman, J., Moradi, A., Yunis, J., Ivison, G., Mayer, A. and O'Byrne, K. (2023). High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer. 2023 World Conference on Lung Cancer, Singapore, Singapore, 9 - 12 September 2023. New York, NY, United States: Elsevier.

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken and Kulasinghe, Arutha (2023). Identifying a role for macrophages in predicting immunotherapy responses of non-small cell lung cancer (NSCLC). Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0105

Jhaveri, Niyati, Klymyshyn, Dmytro, Pratapa, Aditya, Cheikh, Bassem Ben, Monkman, James, Prater, Michael, Nelson, Nadine, Mammadova, Najiba and Kulasinghe, Arutha (2023). Spatio-temporal monitoring of the tumor microenvironment in cutaneous squamous cell carcinoma. Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0090

Kulasinghe, Arutha (2023). From pixels to clinical Insights: deciphering spatial tumour-immune microenvironment features of immunotherapy response and resistance in lung cancer. Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0099

Ladwa, R., Monkman, J., Sadeghirad, H., Cooper, C., Belz, G., Bowman, J., Schaider, H., Liu, H., Kulasinghe, A. and Porceddu, S. (2023). High-plex spatial profiling of cutaneous squamous cell carcinoma to identify biomarkers associated with clinical outcomes: The cMIC study. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.2278

Kulasinghe, A., Ma, N., Pratapa, A., Monkman, J., Braubach, O. and O'Byrne, K. J. (2023). Multi-omic spatial phenotyping of the NSCLC tumour microenvironment for the development of a spatial score associated with immunotherapy resistance. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.1352

Ji, HaYeun, Jhaveri, Niyati, Pratapa, Aditya, Ma, Ning, Ben Cheikh, Bassem, Monkman, James, O'Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer. Annual Meeting of the American-Association-of-Immunologists (AAI), Washington Dc, May 11-15, 2023. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Ji, HaYeun, Jhaveri, Niyati, Pratapa, Aditya, Ma, Ning, Ben Cheikh, Bassem, Monkman, James, O’Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.171.09

Ji, HaYeun, Jhaveri, Niyati, Ma, Ning, Cheikh, Bassem B., Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-5647

Sadeghirad, Habib, Liu, Ning, Monkman, James, Tan, Chin Wee, Cooper, Caroline, Caldera, Jeni, Church, Sarah, Schneider, Fabian, Mansfield, James Robert, O'Byrne, Ken, Davis, Melissa, Hughes, Brett and Kulasinghe, Arutha (2023). Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-4626

Jhaveri, Niyati, Klymyshyn, Dmytro, Cheikh, Bassem B., Monkman, James, Winkowski, Dan, Mansfield, James, Basu, Subham, Prater, Michael, Nelson, Nadine, Belz, Gabrielle, Braubach, Oliver and Kulasinghe, Arutha (2023). Abstract 6774: The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-6774

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Braubach, Oliver and Kulasinghe, Arutha (2023). Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-6768

Monkman, James, Moradi, Afshin, O'Leary, Connor, Wu, Zhenqin, Hamel, Steven, Mason, David, Schneider, Fabian, Mansfield, James Robert, Meyer, Aaron, O'Byrne, Ken and Kulasinghe, Arutha (2023). Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-4627

Kulasinghe, Arutha (2023). Multiomic dissection of immunotherapy response groups in lung cancer. HOBOKEN: WILEY.

O'Leary, Connor, Monkman, James, Richard, Derek, O'Byrne, Kenneth, Kulasinghe, Arutha and Adams, Mark (2023). Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy. Australian Lung Cancer Conference 2023, Gold Coast, QLD Australia, 15-17 February 2023. Richmond, VIC Australia: John Wiley & Sons.

Kulasinghe, Arutha, Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Cumberbatch, Marie, Bhagat, Milan, Schneider, Fabian, Thaagard, Jeppe, Mansfield, James, Ladwa, Rahul, Mueller, Scott, Adams, Mark and O’byrne, Kenneth (2022). Delineation of spatial tissue signatures of immunotherapy response groups in non-small cell lung cancer (NSCLC). SITC 37th Annual Meeting (SITC 2022), Boston, MA USA, 8-12 November 2022. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/jitc-2022-sitc2022.0118

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Braubach, Oliver and Kulasinghe, Arutha (2022). Decoding immunotherapy responses with high-dimensional and high-throughput spatial phenotyping of non-small cell lung cancer (NSCLC). SITC 37th Annual Meeting (SITC 2022), Boston, MA USA, 8-12 November 2022. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/jitc-2022-sitc2022.0120

Kulasinghe, Arutha, Tan, Chin Wee, Liu, Ning, Monkman, James, Killingbeck, Emily, Kim, Youngmi, Pan, Liuliu, Blick, Tony, Bhuva, Dharmesh, Feher, Kristen, Leon, Michael, Gregory, Mark, Short, Kirsty, Guimaraes, Fernando, Rhodes, Michael, Belz, Gabrielle and Davis, Melissa (2022). Deep single-cell, proteogenomic insights from SARS-CoV-2 infected lung tissues. SITC 37th Annual Meeting (SITC 2022), Boston, MA USA, 8-12 November 2022. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/jitc-2022-sitc2022.0923

Kulasinghe, Arutha, Sadeghirad, Habib, Liu, Ning, Monkman, James, Tan, Chin Wee, Cooper, Caroline, Church, Sarah, Schneider, Fabian, Thaagard, Jeppe, Mansfield, James, O’byrne, Kenneth, Davis, Melissa and Hughes, Brett (2022). High-plex spatial proteomic profiling of immunotherapy response groups in head and neck cancer identifies tissue signatures associated with therapy response. SITC 37th Annual Meeting (SITC 2022), Boston, MA United States, 8–12 November 2022. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2022-sitc2022.0117

Kulasinghe, Arutha, Jhaveri, Niyati, Klymyshyn, Dmytro, Cheikh, Bassem Ben, Ladwa, Rahul, Liu, Howard, Cooper, Caroline, Belz, Gabrielle, Porceddu, Sandro and Braubach, Oliver (2022). High-dimensional spatial phenotyping of cutaneous squamous cell carcinoma from immune-competent and immunocompromised patients. SITC 37th Annual Meeting (SITC 2022), Boston, MA United States, 8–12 November 2022. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2022-sitc2022.0079

O'Byrne, K. J., Ma, N., Sadeghirad, H., Jhaveri, N., Monkman, J., Pratapa, A., Cheikh, B. Ben, Ladwa, R., Hughes, B. G. M., Braubach, O. and Kulasinghe, A. (2022). High dimensional immuno-phenotyping of immunotherapy response in head and neck cancer. Annual Meeting of the European-Society-for-Medical-Oncology (ESMO), Electr Network, Sep 09-13, 2022. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2022.07.778

Grice, Laura, Ni, Guiyan, Jin, Xinnan, Tran, Minh, Killingbeck, Emily, Gregory, Mark, Mulay, Onkar, Teoh, Siok-Min, Kulasinghe, Arutha, Leon, Michael, Murphy, Sarah, Warren, Sarah, Kim, Youngmi and Nguyen, Quan (2022). Abstract 3817: A single-cell, spatial multiomics atlas and cellular interactome of all major skin cancer types. American Association for Cancer Research Annual Meeting, Philadelphia, PA, United States, 8-13 April 2022. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2022-3817

Ma, Ning, Braubach, Oliver, Rebutini, Patricia Zadorosnei, Machado-Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, de Noronha, Lucia, Souza-Fonseca-Guimaraes, Fernando and Kulasinghe, Arutha (2022). Mapping the spatial biology of COVID-19 immunopathology in placenta tissues. Immunology 2022 Meeting, Portland, OR United States, 6-10 May 2022. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.208.supp.125.20

Kulasinghe, A., Monkman, J. and O'Byrne, K. J. (2021). Stromal compartment specific gene signatures dissect immunotherapy response groups in non-small cell lung cancer. ESMO Immuno-Oncology Congres, Electr Network, Dec 08-11, 2021. AMSTERDAM: ELSEVIER. doi: 10.1016/j.annonc.2021.10.032

Monkman, James, Kulasinghe, Arutha, O’Leary, Connor, Richard, Derek and O’Byrne, Ken (2021). The role of the immune microenvironment in EGFR mutant NSCLC. 19th Annual British Thoracic Oncology Group Conference, Online, 22-23 April 2021. Shannon, Ireland: Elsevier Ireland. doi: 10.1016/s0169-5002(21)00204-x

Kulasinghe, Arutha, Monkman, James, Dutta, Sanjay, O’Leary, Connor, Ladwa, Rahul and O’Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). 19th Annual British Thoracic Oncology Group Conference 2021, Virtual, 22-23 April 2021. Shannon, Ireland: Elsevier Ireland. doi: 10.1016/s0169-5002(21)00199-9

Dutta, Sanjay, Leo, Paul, Kulasinghe, Arutha, Monkman, James, Pennisi, David, Roberts, Kate, Ladwa, Rahul and O’Byrne, Ken (2021). Genetic mutations and signatures in lung cancer – findings from a whole exome sequencing platform. 19th Annual British Thoracic Oncology Group Conference 2021, Virtual, 22-23 April 2021. Shannon, Ireland: Elsevier Ireland. doi: 10.1016/s0169-5002(21)00200-2

Kulasinghe, Arutha, Monkman, James, Dutta, Sanjay, O'Leary, Connor, Ladwa, Rahul and O'Byrne, Ken (2021). The identification of circulating tumour DNA using MassARRAY technology in non-small-cell lung cancer (NSCLC). 19th Annual British Thoracic Oncology Group Conference 2021, Virtual, 22-23 April 2021. Shannon, Ireland: Elsevier. doi: 10.1016/S0169-5002(21)00199-9

Kulasinghe, Arutha, O’Leary, Connor, Ladwa, Rahul, Warkiani, Majid and O’byrne, Kenneth (2020). Highly multiplexed digital spatial profiling of the tumor microenvironment of non-small-cell lung cancer (NSCLC). 35th Anniversary Annual Meeting (SITC 2020), Virtual, 9-14 November 2020. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2020-sitc2020.0043

Kulasinghe, Arutha, Kapeleris, Joanna, Kenny, Liz, Hughes, Brett, Warkiani, Majid, Vela, Ian, Thiery, Jean-Paul, O'Byrne, Ken and Punyadeera, Chamindie (2020). Abstract 3384: characterization of the tumor microenvironment and liquid biopsy in head and neck and non-small cell lung cancer. AACR Annual Meeting 2020, Philadelphia, PA USA, 27-28 April 2020 and 22-24 June 2020. Philadelphia, PA USA: American Association for Cancer Research. doi: 10.1158/1538-7445.am2020-3384

Kulasinghe, Arutha, Kapeleris, Joanna, Kenny, Liz, Warkiani, Majid, Vela, Ian, Thiery, Jean Paul, O’Byrne, Ken and Punyadeera, Chamindie (2020). Abstract A03: isolation, characterization, and expansion of circulating tumor cells in head and neck cancers. AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research, Austin, TX USA, 29-30 April 2019. Philadelphia, PA USA: American Association for Cancer Research. doi: 10.1158/1557-3265.aacrahns19-a03

O'Byrne, Kenneth John, Kapeleris, Joanna, Kulasinghe, Arutha, Warkiani, Majid E., O'Leary, Connor Gerard, Ladwa, Rahul, Vela, Ian, Leo, Paul, Sternes, Peter and Punyadeera, Chamindie (2020). Culture of circulating tumour cells derived from non-small cell lung cancer. 2020 ASCO Annual Meeting, Online, 30 May 2020. Alexandria, VA USA: American Society of Clinical Oncology. doi: 10.1200/jco.2020.38.15_suppl.e21692

Kulasinghe, Arutha, Perry, Chris, Kenny, Liz, Blick, Tony, Warkiani, Majid, Vela, Ian, O'Byrne, Ken, Thiery, Jean-Paul, Thompson, Erik, Nelson, Colleen and Punyadeera, Chamindie (2018). Abstract 5572: Circulating tumor cells: The tumor trail left in the blood. Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago Il, Apr 14-18, 2018. PHILADELPHIA: American Association for Cancer Research. doi: 10.1158/1538-7445.am2018-5572

Kulasinghe, Arutha, Monkman, James, Tubelleza, Rafael, Kilgallon, Aaron and Lawler, Clara (2025). Metabolic microenvironment predictors of NSCLC immunotherapy response. The University of Queensland. (Dataset) doi: 10.48610/73b218c

Monkman, James, Kim, Honesty, Mayer, Aaron, Mehdi, Ahmed, Matigian, Nicholas, Cumberbatch, Marie, Bhagat, Milan, Ladwa, Rahul, Mueller, Scott N., Adams, Mark N., O’Byrne, Ken and Kulasinghe, Arutha (2021). IL-2 stromal signatures dissect immunotherapy response groups in nonsmall cell lung cancer (NSCLC). doi: 10.1101/2021.08.05.21261528

Kulasinghe, Arutha Jeevana (2021). Circulating tumour cells in head and neck cancers. PhD Thesis, Faculty of Health, Queensland University of Technology. doi: 10.5204/thesis.eprints.110534

Associate Professor Arutha Kulasinghe

Researcher biography

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Journal Articles

Conference Papers

Data Collection

Preprint

Thesis