Dr Megan Soon
Postdoctoral Research Fellow in Immunology Singel Cell Bioinformatics
Frazer Institute
+61 7 344 36985
Journal Articles
Webster, Rebecca, Oyong, Damian A., Llewellyn, Stacey, Abd-Rahman, Azrin N., Potter, Adam J., Mukhiya, Reena, Sahai, Nischal, Leelasena, Indika, Ujvary, Eniko, Mathison, Sue, Andrew, Dean W., Bukali, Luzia, de Labastida Rivera, Fabian, Engel, Jessica, Soon, Megan S. F., Frame, Teija, Hamelink, Julianne, Nalubega, Mayimuna, Dooley, Nicholas L., Loughland, Jessica R., Nguyen, Tran, Rosenberg-Hasson, Yael, Maysel-Auslender, Sofia, Sigal, Natalia, Foygel, Kira, Gower, Jeremy, Peters, Jenny, Woo, Ria, Amante, Fiona ... Boyle, Michelle J. (2025). Adjunctive ruxolitinib attenuates inflammation and enhances immunity in volunteers experimentally infected with Plasmodium falciparum. Science Translational Medicine, 17 (826) eaea2531, 1-15. doi: 10.1126/scitranslmed.aea2531
Xu, Xiaohan, Saxon, John, Soon, Megan Sioe Fei, Lee, Colin Y. C. and Tuong, Zewen Kelvin (2025). Data standards for single‐cell RNA‐sequencing of paediatric cancer. Clinical & Translational Immunology, 14 (5) e70033, e70033-5. doi: 10.1002/cti2.70033
Lee, Hyun Jae, Moreira, Marcela L., Li, Shihan, Asatsuma, Takahiro, Williams, Cameron G., Skinner, Oliver P., Asad, Saba, Bramhall, Michael, Jiang, Zhe, Liu, Zihan, Kerr, Ashlyn S., Engel, Jessica A., Soon, Megan S. F., Straube, Jasmin, Barrera, Irving, Murray, Evan, Chen, Fei, Nideffer, Jason, Jagannathan, Prasanna and Haque, Ashraful (2024). CD4+ T cells display a spectrum of recall dynamics during re-infection with malaria parasites. Nature Communications, 15 (1) 5497, 1-18. doi: 10.1038/s41467-024-49879-6
Williams, Cameron G., Moreira, Marcela L., Asatsuma, Takahiro, Lee, Hyun Jae, Li, Shihan, Burn, Thomas N., Barrera, Irving, Murray, Evan, Soon, Megan S. F., Engel, Jessica A., Khoury, David S., Le, Shirley, Wanrooy, Brooke J., Schienstock, Dominick, Alexandre, Yannick O., Skinner, Oliver P., Joseph, Rainon, Beattie, Lynette, Mueller, Scott N., Chen, Fei and Haque, Ashraful (2024). Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells (vol 43, 114317, 2024). Cell Reports, 43 (9) 114754. doi: 10.1016/j.celrep.2024.114754
Williams, Cameron G., Moreira, Marcela L., Asatsuma, Takahiro, Lee, Hyun Jae, Li, Shihan, Barrera, Irving, Murray, Evan, Soon, Megan S. F., Engel, Jessica A., Khoury, David S., Le, Shirley, Wanrooy, Brooke J., Schienstock, Dominick, Alexandre, Yannick O., Skinner, Oliver P., Joseph, Rainon, Beattie, Lynette, Mueller, Scott N., Chen, Fei and Haque, Ashraful (2024). Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+T cells. Cell Reports, 43 (6) 114317, 1-28. doi: 10.1016/j.celrep.2024.114317
Irac, Sergio E., Soon, Megan Sioe Fei, Borcherding, Nicholas and Tuong, Zewen Kelvin (2024). Single-cell immune repertoire analysis. Nature Methods, 21 (5), 777-792. doi: 10.1038/s41592-024-02243-4
Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2024). Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 25 (4), 716-716. doi: 10.1038/s41590-024-01770-8
Dooley, Nicholas L., Chabikwa, Tinashe G., Pava, Zuleima, Loughland, Jessica R., Hamelink, Julianne, Berry, Kiana, Andrew, Dean, Soon, Megan S. F., SheelaNair, Arya, Piera, Kim A., William, Timothy, Barber, Bridget E., Grigg, Matthew J., Engwerda, Christian R., Lopez, J. Alejandro, Anstey, Nicholas M. and Boyle, Michelle J. (2023). Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets. Nature Communications, 14 (1) 7387, 1-22. doi: 10.1038/s41467-023-43181-7
Lansink, Lianne I. M., Skinner, Oliver P., Engel, Jessica A., Lee, Hyun Jae, Soon, Megan S. F., Williams, Cameron G., SheelaNair, Arya, Pernold, Clara P. S., Laohamonthonkul, Pawat, Akter, Jasmin, Stoll, Thomas, Hill, Michelle M., Talman, Arthur M., Russell, Andrew, Lawniczak, Mara, Jia, Xiaoxiao, Chua, Brendon, Anderson, Dovile, Creek, Darren J., Davenport, Miles P., Khoury, David S. and Haque, Ashraful (2023). Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites. mBio, 14 (4). doi: 10.1128/mbio.01129-23
Ng, Susanna S., De Labastida Rivera, Fabian, Yan, Juming, Corvino, Dillon, Das, Indrajit, Zhang, Ping, Kuns, Rachel, Chauhan, Shashi Bhushan, Hou, Jiajie, Li, Xian-Yang, Frame, Teija C. M., McEnroe, Benjamin A., Moore, Eilish, Na, Jinrui, Engel, Jessica A., Soon, Megan S. F., Singh, Bhawana, Kueh, Andrew J., Herold, Marco J., Montes de Oca, Marcela, Singh, Siddharth Sankar, Bunn, Patrick T., Aguilera, Amy Roman, Casey, Mika, Braun, Matthias, Ghazanfari, Nazanin, Wani, Shivangi, Wang, Yulin, Amante, Fiona H. ... Engwerda, Christian R. (2020). The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology, 21 (10), 1205-1218. doi: 10.1038/s41590-020-0758-6
Soon, Megan S. F., Lee, Hyun Jae, Engel, Jessica A., Straube, Jasmin, Thomas, Bryce S., Pernold, Clara P. S., Clarke, Lachlan S., Laohamonthonkul, Pawat, Haldar, Rohit N., Williams, Cameron G., Lansink, Lianne I. M., Moreira, Marcela L., Bramhall, Michael, Koufariotis, Lambros T., Wood, Scott, Chen, Xi, James, Kylie R., Lönnberg, Tapio, Lane, Steven W., Belz, Gabrielle T., Engwerda, Christian R., Khoury, David S., Davenport, Miles P., Svensson, Valentine, Teichmann, Sarah A. and Haque, Ashraful (2020). Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nature Immunology, 21 (12), 1597-1610. doi: 10.1038/s41590-020-0800-8
Lam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650
Akter, Jasmin, Khoury, David S., Aogo, Rosemary, Lansink, Lianne I. M., SheelaNair, Arya, Thomas, Bryce S., Laohamonthonkul, Pawat, Pernold, Clara P. S., Dixon, Matthew W. A., Soon, Megan S. F., Fogg, Lily G., Engel, Jessica A., Elliott, Trish, Sebina, Ismail, James, Kylie R., Cromer, Deborah, Davenport, Miles P. and Haque, Ashraful (2019). Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathogens, 15 (2) e1007599, e1007599. doi: 10.1371/journal.ppat.1007599
Aogo, Rosemary A., Khoury, David S., Cromer, Deborah, Elliott, Trish, Akter, Jasmin, Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Soon, Megan S. F., Thomas, Bryce S., Pernold, Clara P. S., Romanczuk, Aleksandra S., Laohamonthonkul, Pawat, Haque, Ashraful and Davenport, Miles P. (2018). Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice. International Journal for Parasitology, 48 (12), 903-913. doi: 10.1016/j.ijpara.2018.05.010
Kerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R. and Mattarollo, Stephen R. (2018). Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia. OncoImmunology, 7 (10) e1486952, 1-10. doi: 10.1080/2162402x.2018.1486952
Soon, Megan S F and Haque, Ashraful (2018). Recent insights into CD4 Th cell differentiation in malaria. Journal of Immunology, 200 (6), 1965-1975. doi: 10.4049/jimmunol.1701316
James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782
McKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599
Fernandez-Ruiz, Daniel, Lau, Lei Shong, Ghazanfari, Nazanin, Jones, Claerwen M., Ng, Wei Yi, Davey, Gayle M., Berthold, Dorothee, Holz, Lauren, Kato, Yu, Enders, Matthias H., Bayarsaikhan, Ganchimeg, Hendriks, Sanne H., Lansink, Lianne I. M., Engel, Jessica A., Soon, Megan S. F., James, Kylie R., Cozijnsen, Anton, Mollard, Vanessa, Uboldi, Alessandro D., Tonkin, Christopher J., de Koning-Ward, Tania F., Gilson, Paul R., Kaisho, Tsuneyasu, Haque, Ashraful, Crabb, Brendan S., Carbone, Francis R., McFadden, Geoffrey I. and Heath, William R. (2017). Development of a novel CD4+ TCR transgenic line that reveals a dominant role for CD8+ dendritic cells and CD40 signaling in the generation of helper and CTL responses to blood-stage malaria. The Journal of Immunology, 199 (12), 4165-4179. doi: 10.4049/jimmunol.1700186
Khoury, David S., Cromer, Deborah, Elliott, Trish, Soon, Megan S. F., Thomas, Bryce S., James, Kylie R., Best, Shannon E., Aogo, Rosemary A., Engel, Jessica A., Gartlan, Kate H., Akter, Jasmin, Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2017). Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo. International Journal for Parasitology, 47 (14), 913-922. doi: 10.1016/j.ijpara.2017.05.009
Khoury, David S., Cromer, Deborah, Akter, Jasmin, Sebina, Ismail, Elliott, Trish, Thomas, Bryce S., Soon, Megan S. F., James, Kylie R., Best, Shannon E., Haque, Ashraful and Davenport, Miles P. (2017). Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection. Proceedings of the National Academy of Sciences of the United States of America, 114 (29), 7701-7706. doi: 10.1073/pnas.1618939114
Lönnberg, Tapio, Svensson, Valentine, James, Kylie R., Fernandez-Ruiz, Daniel, Sebina, Ismail, Montandon, Ruddy, Soon, Megan S. F., Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Stubbington, Michael J. T., Ly, Lam-Ha, Bagger, Frederik Otzen, Zwiessele, Max, Lawrence, Neil D., Souza-Fonseca-Guimaraes, Fernando, Bunn, Patrick T., Engwerda, Christian R., Heath, William R., Billker, Oliver, Stegle, Oliver, Haque, Ashraful and Teichmann, Sarah A. (2017). Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFHfate bifurcation in malaria. Science Immunology, 2 (9) eaal2192, eaal2192. doi: 10.1126/sciimmunol.aal2192
McKee, Sara J., Doff, Brianna L., Soon, Megan S. F. and Mattarollo, Stephen R. (2017). Therapeutic efficacy of 4-1BB costimulation is abrogated by PD-1 blockade in a model of spontaneous B-cell lymphoma. Cancer Immunology Research, 5 (3), 191-197. doi: 10.1158/2326-6066.CIR-16-0249
Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999
Conference Papers
Coyle, Carl, Suwakulsiri, Wittaya, Andriessen, Lukas, Soon, Megan, Wehr, Pascale, Qureshi, Sumera, Altmann, Christopher, Small, Annabelle, Wong, Vincent, Cope, Andrew, Wei, Kevin, Nel, Hendrik, Wechalekar, Mihir and Thomas, Ranjeny (2025). Expansion of viral-reactive CD8+T cell repertoire stratified by pathotype in new-onset ACPA plus rheumatoid arthritis. Unknown, Unknown, Unknown. Hoboken, NJ United States: John Wiley & Sons.
Cai, Benjamin, Soon, Megan, Tuong, Zewen Kelvin, Morrison, Mark, Bergot, Anne-Sophie and Thomas, Ranjeny (2025). Enrichment of putative bacteria-reactive gut-derived IL-17+tissue resident memory helper T cells in arthritic ankles in the SKG mouse model of spondyloarthritis. ACR Convergence 2025, Chicago, IL, United States, 24 – 29 October 2025. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/art.43421
Lansink, Lianne I. M., Engel, Jessica A., Lee, Hyun Jae, Soon, Megan S. F., Williams, Cameron G., Aogo, Rosemary A., Cromer, Deborah, Davenport, Miles P., Khoury, David S. and Haque, Ashraful (2021). Exposure to host inflammation in vivo induces rapid transcriptomic change and impaired maturation in malaria parasites. Immunology 2021™ Meeting, Virtual, 10-15 May 2021. Cary, NC, United States: Oxford University Press. doi: 10.4049/jimmunol.206.Supp.99.22
Williams, Cameron Gerard, Engel, Jessica A., Soon, Megan S. F., Murray, Evan, Chen, Fei and Haque, Ashraful (2021). Studying lymphocyte differentiation in the spleen via spatial transcriptomics. Immunology 2021™ Meeting, Virtual, 10-15 May 2021. Cambridge, United Kingdom: Oxford University Press. doi: 10.4049/jimmunol.206.Supp.98.55
Loennberg, Tapio, James, Kylie, Svensson, Valentine, Fernandez-Ruiz, Daniel, Sebina, Ismail, Montandon, Ruddy, Soon, Megan, Stubbington, Michael, Souza-Fonseca-Guimaraes, Fernando, Heath, William, Billker, Oliver, Haque, Ashraful and Teichmann, Sarah (2016). Resolving T helper cell fate decisions using single-cell RNA-sequencing. 43rd Meeting of the Scandinavian Society for Immunology (SSI), Turku, Finland, 10-13 May 2016. Chichester, West Sussex United Kingdom: Wiley-Blackwell Publishing.
Doff, B., Soon, M., Kobayashi, T., McKee, S. and Mattarollo, S. (2016). Therapeutic vaccination enhances 4-1BB-mediated anti-tumor CD8 T cell immunity against poorly immunogenic haematological cancers. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley-VCH. doi: 10.1002/eji.201670200
Thesis
Soon, Sioe Fei (2021). Effector and memory CD4+ T cell development during experimental blood-stage malaria. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/6a26f34