Associate Professor Andrew Brooks
Principal Research Fellow
Frazer Institute
Dr Andrew Brooks leads the Cytokine receptor signalling group.
Research projects
Class I cytokine receptors
Members of the class 1 cytokine receptor family are important therapeutic targets in cancers, inflammatory bowel disease, osteoporosis, multiple sclerosis, and disorders related to blood cell formation, postnatal growth, obesity, lactation, and neural function. Loss or gain of function mutations in these receptors are known to lead to a wide variety of clinically important disorders. Class I cytokine receptors regulate a wide range of clinically relevant and cellular processes. This family contains around 30 members including receptors for erythropoietin (EPO), prolactin (PRL), growth hormone (GH), thrombopoietin (TPO), granulocyte-macrophage colony-stimulating factor (GM-CSF), leukaemia inhibitory factor (LIF), interleukin-3 (IL-3), IL-5, and IL-6. Despite great progress in elucidating the structural details of ligand binding to the extracellular domain of receptors for several members of this family, the means by which these receptors activate their associated JAK kinases to initiate signalling has remained elusive. Recently we elucidated the mechanism of action of the archetypal class I cytokine receptor, the GH receptor (GHR), in unprecedented detail (published in Science 2014). Next we plan to determine if the same or similar mechanism exist for the related homodimeric and heterodimeric cytokine receptors. By utilising this new molecular understanding we will develop potential therapeutic molecules by targeting a novel region of these cytokine receptors.
- Understanding the mechanism of cytokine receptor activation
- Understanding the mechanism of the JAK2 kinase activation
- How mutations in cytokine receptor signalling pathways contribute to cancer
Student opportunities
- Defining the molecular mechanism of JAK2 activation by the EPO receptor
- Molecular mechanism for activation of Src by the Growth Hormone receptor.
- Defining the molecular mechanism of JAK2 activation by the Prolactin receptor
- Defining the molecular mechanism of JAK2 activation by the GM-CSF receptor
- Defining the molecular mechanism of JAK2 activation by the IL-6 receptor
Contact: a.brooks@uq.edu.au
Researcher biography
Dr Andrew Brooks is the Group Leader of the Cytokine Receptor Signalling Group at the University of Queensland Diamantina Institute (UQ DI) within the Translational Research Institute. Andrew completed his Honours research on Flaviviruses in 1996 at the Department of Microbiology and Immunology at James Cook University and then moved to the Department of Biochemistry to study Dengue Virus where he completed his PhD in 2002. He then moved to St Jude Children's Research Hospital in Memphis, TN, USA where he researched the role of Epstein-Barr Virus in B-cell lymphomagenesis. He then joined the research group headed by Prof Michael Waters at the Institute for Molecular Bioscience, UQ in 2006 and subsequently began his independent research group at UQ DI in 2014. Andrew's research interests are in cytokine receptors, cell signalling, oncogenesis, and immunology. His current research focus is on the molecular mechanisms of class I cytokine receptor activation including the growth hormone receptor (GHR), thrombopoietin receptor (TpoR/MPL), IL-7 receptor, and IL-6 receptor (IL-6R). In addition, he is investigating the regulation of inflammation by HLA-G. His research has led to publications in journals including Science, Blood, Hepatology, Oncogene, Nature Cell Biology, and PNAS. He has been the secured of over $12 million in research and commercialisation funding from sources including NHMRC, ARC, Innovation Connections, and Merck. He has a number of national and international collaborations, a scientific founder of a start-up company, and is an Editorial Board member for the Journal Cancers and Human Cell. He was previously a committee member of Australian Early-Mid Career Researchers Forum (AEMCRF) launched by the Australian Academy of Science.
Book Chapters
Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe (2018). Cytokine receptors. Endocrinology: principles of endocrinology and hormone action. (pp. 157-185) edited by Antonino Belfiore and Derek LeRoith. Amsterdam, The Netherlands: Springer. doi: 10.1007/978-3-319-44675-2_8
Brooks, Andrew J., Dehkhoda, Farhad and Kragelund, Birthe B. (2017). Cytokine Receptors. Principles of Endocrinology and Hormone Action. (pp. 1-29) Cham, Switzerland: Springer. doi: 10.1007/978-3-319-27318-1_8-2
Herington, Adrian C. and Brooks, Andrew J. (2014). Growth hormone-binding proteins. Reference module in biomedical research. (pp. 390-395) edited by Michael Caplan. Philadelphia, PA, United States: Elsevier. doi: 10.1016/B978-0-12-801238-3.04053-8
Brooks, Andrew J., Johansson, Magnus, Criswell, Erin, Jans, David A. and Vasudevan, Subhash G. (2002). The interdomain region of dengue NS5 protein interacts with NS3 and host proteins. Dengue Bulletin. (pp. 155-161) New Delhi, India.: WHO Regional Office for South-East Asia.
Journal Articles
Chhabra, Yash, Bielefeldt-Ohmann, Helle, Brooks, Tania Louise, Brooks, Andrew James and Waters, Michael J (2024). The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence. Endocrinology, 165 (11) ARTN bqae136. doi: 10.1210/endocr/bqae136
Rossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 102 (10), 1-11. doi: 10.1111/imcb.12820
Fernandez-Rojo, Manuel A., Pearen, Michael A., Burgess, Anita G., Ikonomopoulou, Maria P., Hoang-Le, Diem, Genz, Berit, Saggiomo, Silvia L., Nawaratna, Sujeevi S. K., Poli, Maura, Reissmann, Regina, Gobert, Geoffrey N., Deutsch, Urban, Engelhardt, Britta, Brooks, Andrew J., Jones, Alun, Arosio, Paolo and Ramm, Grant A. (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science Signaling, 17 (830) eade4335, 1-16. doi: 10.1126/scisignal.ade4335
Wahjudi, Handoko, Bovill, William D., Brooks, Andrew J. and Downes, Barbara J. (2024). Seasonal differences in amounts of oviposition habitat and egg-laying by caddisflies in rivers with regulated versus unregulated flows. Freshwater Biology, 69 (5), 645-659. doi: 10.1111/fwb.14236
Kefford, Ben J., Brooks, Andrew J., Shenton, Mark D., Hills, Kasey, Nichols, Susan J., Bray, Jonathan P. and Hyne, Ross V. (2024). Do magnesium and chloride ameliorate high sodium bicarbonate concentrations? A comparison between laboratory and mesocosm toxicity experiments. Science of the Total Environment, 912 169003, 1-13. doi: 10.1016/j.scitotenv.2023.169003
Gormal, Rachel S., Martinez-Marmol, Ramon, Brooks, Andrew J. and Meunier, Frédéric A. (2024). Location, location, location: Protein kinase nanoclustering for optimised signalling output. eLife, 13 ARTN e93902, 1-21. doi: 10.7554/elife.93902
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2023). Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 14 (1) 7951, 7951. doi: 10.1038/s41467-023-42706-4
Chhabra, Yash, Seiffert, Pernille, Gormal, Rachel S., Vullings, Manon, Lee, Christine Mei Mei, Wallis, Tristan P., Dehkhoda, Farhad, Indrakumar, Sowmya, Jacobsen, Nina L., Lindorff-Larsen, Kresten, Durisic, Nela, Waters, Michael J., Meunier, Frederic A., Kragelund, Birthe B. and Brooks, Andrew J. (2023). Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation. Cell Reports, 42 (5) 112490, 112490. doi: 10.1016/j.celrep.2023.112490
Butler, Liesl, Lee, Christine, Magor, Graham William, Morris, Rhiannon, Tallack, Michael, Lam, Charlene, Ivey, Adam, Lin, Jane, Deng, Zihao, Grigg, Andrew, Mason, Jane, Perchard, Malaika, Weston, Helen, Cummings, Nik, Brooks, Andrew, Babon, Jeffrey J, Murphy, Andrew J, Salmon, Jessica M and Perkins, Andrew Charles (2022). Germline missense variants in SH2B3 underpin platelet count variation and inherited MPN. Blood, 140 (S1), 1093-1094. doi: 10.1182/blood-2022-159416
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J. and Nicholson, Sandra E. (2021). Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nature Communications, 12 (1) 7032, 7032. doi: 10.1038/s41467-021-26983-5
Chhabra, Yash, Lee, Christine M. M., Mueller, Alexandra Franziska and Brooks, Andrew J. (2021). GHR signalling: Receptor activation and degradation mechanisms. Molecular and Cellular Endocrinology, 520 111075, 1-11. doi: 10.1016/j.mce.2020.111075
Brooks, Andrew J., Ishikawa, Mayumi, Fernández‐Rojo, Manuel A., Vivian, Julian P., Rossjohn, Jamie and Waters, Michael J. (2020). Reply to Letter to the Editors: Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy Allowing Liver Regeneration and Survival by Induction of H2‐Bl/HLA‐G. Hepatology, 73 (3) hep.31531, 1239-1239. doi: 10.1002/hep.31531
Brooks, Andrew J. and Putoczki, Tracy (2020). JAK-STAT signalling pathway in cancer. Cancers, 12 (7) 1971, 1971-3. doi: 10.3390/cancers12071971
Ishikawa, Mayumi, Brooks, Andrew J., Fernández-Rojo, Manuel A., Medina, Johan, Chhabra, Yash, Minami, Shiro, Tunny, Kathryn A., Parton, Robert G., Vivian, Julian P., Rossjohn, Jamie, Chikani, Viral, Ramm, Grant A., Ho, Ken K. Y. and Waters, Michael J. (2020). Growth hormone stops excessive inflammation after partial hepatectomy allowing liver regeneration and survival via induction of H2-Bl/HLA-G. Hepatology, 73 (2) hep.31297, 759-775. doi: 10.1002/hep.31297
Bridgford, Jessica L., Lee, Su Min, Lee, Christine M. M., Guglielmelli, Paola, Rumi, Elisa, Pietra, Daniela, Wilcox, Stephen, Chhabra, Yash, Rubin, Alan F., Cazzola, Mario, Vannucchi, Alessandro M., Brooks, Andrew J., Call, Matthew Edwin and Call, Melissa Joy (2020). Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning. Blood, 135 (4), 287-292. doi: 10.1182/blood.2019002561
Chhabra, Yash, Nelson, Caroline N., Plescher, Monika, Barclay, Johanna L., Smith, Aaron G., Andrikopoulos, Sof, Mangiafico, Salvatore, Waxman, David J., Brooks, Andrew J. and Waters, Michael J. (2019). Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (5), fj201802328R-6430. doi: 10.1096/fj.201802328R
Campos, Livia Weijenborg, Zenatti, Priscila Pini, Pissinato, Leonardo Granato, Rodrigues, Gisele Olinto Libanio, Artico, Leonardo Luís, Guimarães, Thais Rafael, Archangelo, Leticia Fröhlich, Martínez, Leandro, Brooks, Andrew J. and Yunes, Jose Andres (2019). Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7Rα cause receptor hypersensitivity. Blood, 133 (11), 1259-1263. doi: 10.1182/blood-2018-09-872945
Dehkhoda, Farhad , Lee, Christine M. M. , Medina, Johan and Brooks, Andrew J. (2018). The growth hormone receptor: mechanism of receptor activation, cell signaling, and physiological aspects. Frontiers in Endocrinology, 9 (35) 35, 35. doi: 10.3389/fendo.2018.00035
Chhabra, Y., Wong, H. Y., Nikolajsen, L. F., Steinocher, H., Papadopulos, A., Tunny, K. A., Meunier, F. A., Smith, A. G., Kragelund, B. B., Brooks, A. J. and Waters, M. J. (2018). A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation. Oncogene, 37 (4), 489-501. doi: 10.1038/onc.2017.352
De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136). Developmental Cell, 40 (4), 421-421. doi: 10.1016/j.devcel.2017.02.005
De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover. Developmental Cell, 40 (2), 123-136. doi: 10.1016/j.devcel.2016.12.017
Legrand, Julien M. D., Roy, Edwidge, Ellis, Jonathan J., Francois, Mathias, Brooks, Andrew J. and Khosrotehrani, Kiarash (2016). STAT5 activation in the dermal papilla is important for hair follicle growth phase induction. Journal of Investigative Dermatology, 136 (9), 1781-1791. doi: 10.1016/j.jid.2016.04.014
Stewart, Teneale A., Azimi, Iman, Brooks, Andrew J., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells. The International Journal of Biochemistry and Cell Biology, 76, 64-74. doi: 10.1016/j.biocel.2016.05.007
Brooks, Andrew J. and Haeusler, Tim (2016). Invertebrate responses to flow: trait-velocity relationships during low and moderate flows. Hydrobiologia, 773 (1), 23-34. doi: 10.1007/s10750-016-2676-z
Carey, Alison J., Sullivan, Matthew J., Duell, Benjamin L., Crossman, David K., Chattopadhyay, Debasish., Brooks, Andrew J., Tan, Chee K., Crowley, Michael., Sweet, Matthew J., Schembri, Mark A. and Ulett, Glen C. (2015). Uropathogenic Escherichia coli engages CD14-dependent signaling to enable bladder macrophage-dependent control of acute urinary tract infection. The Journal of infectious diseases, 213 (4), 659-668. doi: 10.1093/infdis/jiv424
Bugge, Katrine, Steinocher, Helena, Brooks, Andrew J., Lindorff-Larsen, Kresten and Kragelund, Birthe B. (2015). Exploiting Hydrophobicity for Efficient Production of Transmembrane Helices for Structure Determination by NMR Spectroscopy. Analytical Chemistry, 87 (18), 9126-9131. doi: 10.1021/acs.analchem.5b02365
Haxholm, Gitte W, Nikolajsen, Louise F, Olsen, Johan G, Fredsted, Jacob, Larsen, Flemming H, Goffin, Vincent, Pedersen, Stine F, Brooks, Andrew J, Waters, Michael J and Kragelund, Birthe B (2015). Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes. Biochemical Journal, 468 (3), 495-506. doi: 10.1042/BJ20141243
Waters, Michael J. and Brooks, Andrew J. (2015). JAK2 activation by growth hormone and other cytokines. Biochemical Journal, 466 (1), 1-11. doi: 10.1042/BJ20141293
Brooks, Andrew J. and Waters, Michael J. (2015). Rewriting the mechanism of JAK2 activation. Cell Cycle, 14 (3), 285-286. doi: 10.1080/15384101.2015.1006533
Dingwall, Steven, Brooks, Andrew, Apte, Simon H., Waters, Mike, Lavin, Martin F. and Wolvetang, Ernst J. (2015). Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance. Journal of Stem Cell Research and Therapy, 5 (12) 1000320, 1-8. doi: 10.4172/2157-7633.1000320
Waters, Michael J., Brooks, Andrew J. and Chhabra, Yash (2014). A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors. JAK-STAT, 3 (e29569), 1-6. doi: 10.4161/jkst.29569
Brooks, Andrew J., Dai, Wei, O’Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science, 344 (6185) 1249783, 1249783.1-1249783.12. doi: 10.1126/science.1249783
Waters, Micheal and Brooks, Andrew (2014). Why don't some dwarves get cancer?. Australasian Science, 35 (9), 22-23.
Fernández Rojo, Manuel, Gongora, Milena, Fitzsimmons, Rebecca L., Martel, Nick, Martin, Sheree D., Nixon, Susan, Brooks, Andrew J., Ikonomopoulou, Maria P., Martin, Sally, Lo, Harriet P., Myers, Stephen A., Restall, Christina, Ferguson, Charles, Pilch, Paul F., McGee, Sean L., Anderson, Robin L., Waters, Michael J., Hancock, John F., Grimmond, Sean M., Muscat, George E. and Parton, Robert G. (2013). Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling. Cell Reports, 4 (2), 238-247. doi: 10.1016/j.celrep.2013.06.017
Duell, Benjamin L., Carey, Alison J., Tan, Chee K., Cui, Xiangqin, Webb, Richard I., Totsika, Makrina, Schembri, Mark A., Derrington, Petra, Irving-Rodgers, Helen, Brooks, Andrew J., Cripps, Allan W., Crowley, Michael and Ulett, Glen C. (2012). Innate transcriptional networks activated in bladder in response to uropathogenic Escherichia coli drive diverse biological pathways and rapid synthesis of IL-10 for defense against bacterial urinary tract infection. Journal of Immunology, 188 (2), 781-792. doi: 10.4049/jimmunol.1101231
Chhabra, Yash, Waters, Michael J. and Brooks, Andrew J. (2011). Role of the growth hormone–IGF-1 axis in cancer. Expert Review of Endocrinology and Metabolism, 6 (1), 71-84. doi: 10.1586/eem.10.73
Brooks, Andrew J. and Waters, Michael J. (2010). The growth hormone receptor: mechanism of activation and clinical implications. Nature Reviews Endocrinology, 6 (9), 515-525. doi: 10.1038/nrendo.2010.123
Conway-Campbell, B. L., Brooks, A. J., Robinson, P. J., Perani, M. and Waters, M. J. (2008). The extracellular domain of the growth hormone receptor interacts with coactivator to promote cell proliferation. Molecular Endocrinology, 22 (9), 2190-2202. doi: 10.1210/me.2008-0128
Rowlinson, Scott W., Yoshizato, Hideo, Barclay, Johanna L., Brooks, Andrew J., Behncken, Stuart N., Kerr, Linda M., Millard, Kirstin, Palethorpe, Kathryn, Nielsen, Katherine, Clyde-Smith, Jodie, Hancock, John F. and Waters, Michael J. (2008). An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway. Nature Cell Biology, 10 (6), 740-747. doi: 10.1038/ncb1737
Brooks, Andrew J., Wooh, Jong Wei, Tunny, Kathryn A. and Waters, Michael J. (2008). Growth hormone receptor; mechanism of action. The International Journal of Biochemistry and Cell Biology, 40 (10), 1984-1989. doi: 10.1016/j.biocel.2007.07.008
Conway-Campbell, B., Wooh, J., Brooks, A., Gordon, D, Brown, R. J., Lichanska, A. M., Chin, H., Barton, C., Boyle, G., Parsons, P., Jans, D. A. and Waters, M. J. (2007). Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proceedings of The National Academy of Sciences of The United States of America, 104 (33), 13331-13336. doi: 10.1073/pnas.0600181104
Jiménez-Ramírez, Carmilia, Brooks, Andrew J., Forshell, Linus Plym, Yakimchuk, Konstantin, Zhao, Bo, Fulgham, Tacha Zi and Sample, Clare E. (2006). Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter. Journal of Virology, 80 (22), 11200-11208. doi: 10.1128/JVI.00897-06
Brooks, Andrew J., Johansson, Magnus, Criswell, Erin, Jans, David A. and Vasudevan, Subhash G. (2002). The interdomain region of dengue NS5 protein interacts with NS3 and host proteins. Dengue Bulletin, 26, 155-161.
Brooks, Andrew J., Johansson, Magnus, John, Anna V., Xu, Yibin, Jans, David A. and Vasudevan, Subhash G. (2002). The Interdomain Region of Dengue NS5 Protein That Binds to the Viral Helicase NS3 Contains Independently Functional Importin beta 1 and Importin alpha /beta -Recognized Nuclear Localization Signals. Journal of Biological Chemistry, 277 (39), 36399-36407. doi: 10.1074/jbc.M204977200
Johansson, Magnus, Brooks, Andrew J., Jans, David A. and Vasudevan, Subhash G. (2001). A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-β and the viral helicase, NS3. Journal of General Virology, 82 (4), 735-745. doi: 10.1099/0022-1317-82-4-735
Vasudevan, Subhash G., Johansson, Magnus, Brooks, Andrew J., Llewellyn, Lyndon E. and Jans, David A. (2001). Characterisation of inter- and intra-molecular interactions of the dengue virus RNA dependent RNA polymerase as potential drug targets. Farmaco, 56 (1-2), 33-36. doi: 10.1016/S0014-827X(01)01014-X
Forwood, Jade K., Brooks, Andrew, Briggs, Lyndall J., Xiao, Chong-Yun, Jans, David A. and Vasudevan, Subhash G. (1999). The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site. Biochemical and Biophysical Research Communications, 257 (3), 731-737. doi: 10.1006/bbrc.1999.0370
Conference Papers
Dang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Asplett, Kiran, Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Epithelial cancers demonstrate IL34-associated dysfunction of Langerhans cells. AACR Special Conference in Cancer Research: Tumor Immunology and Immunotherapy, Boston, MA, United States, 18-21 October 2024. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/2326-6074.tumimm24-a001
Dang, T. V. T., Gillinder, K. G., Brooks, A. J., Asplett, K., Tolley, L. K., Hume, D. A., Leggatt, G. R., Frazer, I. H. and Chandra, J. (2022). Gene-therapy based modulation of antigen-presenting cells within hyperproliferative epithelium to restore immunity. 29th Annual Congress of the European-Society-of-Gene-and-Cell-Therapy (ESCGT), Edinburgh, United Kingdom, 11-14 October 2022. New Rochelle, NY United States: Mary Ann Liebert.
Lee, Christine, Brooks, Andrew, Chhabra, Yash and Perkins, Andrew (2019). Specific domains of LNK (SH2B3) bind and regulate TPOR stability and signalling. 48th Annual Scientific Meeting of the Society for Experimental Hematology, Brisbane, Australia, 22-25 August 2019. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2019.06.387
Brooks, Andrew, Campos, Livia, Lee, Christine, Chhabra, Yash, Bridgford, Jessica, Lee, Su Min, Zenatti, Priscila, Pissinato, Leonardo, Rodrigues, Gisele, Artico, Leonardo, Guimarães, Thais, Archangelo, Leticia, Martínez, Leandro, Slape, Christopher, Call, Matthew, Call, Melissa and Yunes, José (2019). The mechanism of oncogenic mutations in the juxtamembrane and transmembrane region of IL7RA and TPOR/MPL. ISEH 2019, Brisbane, Australia, 22-25 August 2019. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2019.06.332
Steinocher, Helena, Bugge, Katrine, Nikolajsen, Louise Fletcher, Lindorff-Larsen, Kresten, Brooks, Andrew and Kragelund, Birthe Brandt (2017). Class I cytokine receptors: towards the inside. 61st Annual meeting of the Biophysical Society, New Orleans, LA, United States, 11-15 February 2017. St. Louis, MO United States: Cell Press. doi: 10.1016/j.bpj.2016.11.947
Brooks, Andrew J., O’Mara, Megan L., Dai, Wei, Abankwa, Daniel, Chhabra, Yash, Tunny, Kathryn A., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Haxholm, Gitte W., Nikolajsen, Louise F., Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2016). Mechanism of JAK2 Activation by the Archetype Class I Cytokine Receptor, the Growth Hormone Receptor. Biophysical Meeting, Los Angeles, CA, United States, 27 February - 2 March 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.233
Brooks, Andrew, Dai, W., O'Mara, M. L., Abankwa, D., Chhabra, Y., Pelekanos, R. A., Gardon, O., Tunny, K. A., Blucher, K. M., Morton, C. J., Parker, M. W., Sierecki, E., Gambin, Y., Gomez, G. A., Alexandrov, K., Wilson, I. A., Doxastakis, M., Mark, A. E. and Waters, M. J. (2016). Going downstream - how does GH binding activate JAK2. Annual Scientific Meeting of the Endocrine Society of Australia, Adelaide, Australia, 23-26 August, 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/cen.13010
Stewart, Teneale A., Azimi, Iman, Davis, Felicity M., Thompson, Erik W., Brooks, Andrew J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). A potential role for Janus protein tyrosine kinases in the regulation of epithelial-mesenchymal transition in a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition. 37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX United States, 9-13 December 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS14-P2-07-05
Bassett, John J., Stewart, Teneale A., Azimi, Iman , Davis, Felicity M., Thompson, Erik W., Brooks, Andrew J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Assessment of Janus protein tyrosine kinases as potential regulators of epithelial-mesenchymal transition using a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC Australia, 7-11 December 2014.
Brooks, Andrew J, Chhabra, Yash, Abankwa, Daniel, O’Mara, Megan, Dai, Wei, Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Guillermo A. Gomez, Alexandrov, Kirill Kirill, Doxastakis, Manolis, Mark, Alan E. and Waters, Michael J. (2014). A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor. 2nd Annual Meeting of the International Cytokine and Interferon Society (ICIS), Melbourne, VIC Australia, 26 - 29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.227
Waters, M. J. and Brooks, A. J. (2014). Mechanism of activation of JAK2 by growth hormone. Seventh International Congress of the GRS and the IGF Society, Singapore, 17-20 October 2014. London, United Kingdom: Churchill Livingstone. doi: 10.1016/S1096-6374(14)50035-4
Chhabra, Yash, Wong, Ho Yi, Brooks, Andrew James and Waters, Michael John (2014). The first cancer-associated variant of the growth hormone receptor. Endocrine Society's 96th Annual Meeting and Expo, Chicago, IL, United States, 21-24 June 2014. WASHINGTON: Endocrine Society.
Waters, Michael J. and Brooks, Andrew J. (2012). Growth hormone and cell growth. 6th ESPE Advanced Seminar in Developmental Endocrinology, Bern, Switzerland, 10-11 May 2012. Basel, Switzerland: S. Karger. doi: 10.1159/000341761
Ishikawa, M., Barclay, J. L., Brooks, A. J., McPhee, T. R., Yoshino, G. and Waters, M. J. (2012). Hepatic IGF-I production is regulated by Kupffer cells. Sixth International Congress of the GRS and the IGF Society, Munich, Germany, 17-20 October 2012. London, United Kingdom: Churchill Livingstone. doi: 10.1016/S1096-6374(12)60056-2
Waters, Michael J. and Brooks, Andrew J. (2011). Growth hormone receptor: structure function relationships. Switzerland: S. Karger AG. doi: 10.1159/000329138
Ishikawa, M., McPhee, T. R., Barclay, J. L., Fernandez-Rojo, M., Brooks, A. J. and Waters, M. J. (2010). Role of growth hormone signaling pathways in liver regeneration. Fifth International congress of the GRS and the IGF Society, New York, NY, United States, 3-7 October. London, United Kingdom: Churchill Livingstone. doi: 10.1016/S1096-6374(10)70011-3