Frazer Institute

Mr Rashad Mahbub

Research Officer
Frazer Institute
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Researcher biography

I am a postdoctoral researcher exploring biotechnology and computational biology to understand health and diseases. My passion lies in leveraging biotech for longevity and innovative healthcare solutions.

My current research focuses on the role of gut microbiome in type-1 diabetes. More specifically, I am interested in identifying early-life biomarkers using multi-omics approach (metagenomics, metabolomics, proteomics), with the goal of enabling early diagnosis for preventation and treatment.

Beyond academia, I am keen on research translation, believing in interdisciplinary collaboration with industry and startups to tackle biotech and AI challenges. I find true solace and inspiration in my faith which instils in me a sense of purpose and compassion for the well-being of others. I like spending time outdoors, and volunteering which keeps me grounded and inspired.

Publications

Journal Articles (5)
Conference Paper (1)

Journal Articles

Nwozor, Kingsley Okechukwu, Hackett, Tillie-Louise, Chen, Qing, Yang, Chen Xi, Aguilar Lozano, Sheila Patricia, Zheng, XinZi, Al-Fouadi, May, Kole, Tessa M., Faiz, Alen, Mahbub, Rashad Mohammad, Slebos, Dirk-Jan, Klooster, Karin, Timens, Wim, van den Berge, Maarten, Brandsma, Corry-Anke and Heijink, Irene H. (2025). Effect of age, COPD severity, and cigarette smoke exposure on bronchial epithelial barrier function. American Journal of Physiology-Lung Cellular and Molecular Physiology, 328 (5), L724-L737. doi: 10.1152/ajplung.00223.2024
Faiz, Alen, Mahbub, Rashad M., Boedijono, Fia Sabrina, Tomassen, Milan I., Kooistra, Wierd, Timens, Wim, Nawijn, Martijn, Hansbro, Philip M., Johansen, Matt D., Pouwels, Simon D., Heijink, Irene H., Massip, Florian, de Biase, Maria Stella, Schwarz, Roland F., Adcock, Ian M., Chung, Kian F., van der Does, Anne, Hiemstra, Pieter S., Goulaouic, Helene, Xing, Heming, Abdulai, Raolat, de Rinaldis, Emanuele, Cunoosamy, Danen, Harel, Sivan, Lederer, David, Nivens, Michael C., Wark, Peter A., Kerstjens, Huib A. M., Hylkema, Machteld N. ... van den Berge, Maarten (2023). IL-33 expression is lower in current smokers at both transcriptomic and protein levels. American Journal of Respiratory and Critical Care Medicine, 208 (10), 1075-1087. doi: 10.1164/rccm.202210-1881oc
Dickson, Kristie-Ann, Field, Natisha, Blackman, Tiane, Ma, Yue, Xie, Tao, Kurangil, Ecem, Idrees, Sobia, Rathnayake, Senani N. H., Mahbub, Rashad M., Faiz, Alen and Marsh, Deborah J (2023). CRISPR single base-editing: in silico predictions to variant clonal cell lines. Human Molecular Genetics, 32 (17), 2704-2716. doi: 10.1093/hmg/ddad105
Johansen, Matt D., Mahbub, Rashad M., Idrees, Sobia, Nguyen, Duc H., Miemczyk, Stefan, Pathinayake, Prabuddha, Nichol, Kristy, Hansbro, Nicole G., Gearing, Linden J., Hertzog, Paul J., Gallego-Ortega, David, Britton, Warwick J., Saunders, Bernadette M., Wark, Peter A., Faiz, Alen and Hansbro, Philip M. (2022). Increased SARS-CoV-2 infection, protease, and inflammatory responses in chronic obstructive pulmonary disease primary bronchial epithelial cells defined with single-cell rna sequencing. American Journal of Respiratory and Critical Care Medicine, 206 (6), 712-729. doi: 10.1164/rccm.202108-1901oc
van der Does, Anne M., Mahbub, Rashad M., Ninaber, Dennis K., Rathnayake, Senani N. H., Timens, Wim, van den Berge, Maarten, Aliee, Hananeh, Theis, Fabian J., Nawijn, Martijn C., Hiemstra, Pieter S. and Faiz, Alen (2022). Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa. Respiratory Research, 23 (1) 227, 1-15. doi: 10.1186/s12931-022-02150-2

Conference Paper

Mahbub, Rashad Mohammad, Gacesa, Ranko, Weersma, Rinse, Oliver, Brian, Vonk, Judith, Van Den Berge, Maarten and Faiz, Alen (2025). Late breaking abstract - Influence of gut microbiome and plasma metabolome on asthma in the Lifelines cohort. Unknown, Unknown, Unknown. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2025.pa5254