Researcher biography
Dr Jun Yan is a molecular biologist, currently working in the field of neurological diseases. Dr Yan's research interest is cell signal transduction pathways invoved in mechanisms of the disease development.
Dr Jun Yan completed her postgraduate study at The University of Queensland, after which she undertook a postdoctoral position in Experimental Oncology laboratory in Department of Patholody, UQ and worked on Ras / Raf signalling pathway. In 2001 she joined the Neuroimmunology Research group in Department of Medicine, UQ, and works on neurological diseases, including autoimmune disease multiple sclerosis (MS), ischaemic stroke and amyotrophic lateral sclerosis (ALS) . She has been investigating NF-kB signal transduction pathway in MS and ALS, and cell immune responese to ischaemic stroke.
Journal Articles
Yan, Jun, McCombe, Pamela A., Pender, Michael P. and Greer, Judith M. (2020). Reduced IκB-α protein levels in peripheral blood cells of patients with multiple sclerosis — a possible cause of constitutive NF-κB activation. Journal of Clinical Medicine, 9 (8) 2534, 2534-13. doi: 10.3390/jcm9082534
Cloake, Nancy, Yan, Jun, Aminian, Atefeh, Pender, Michael and Greer, Judith (2018). PLP1 mutations in patients with multiple sclerosis: identification of a new mutation and potential pathogenicity of the mutations. Journal of Clinical Medicine, 7 (10) 342, 342. doi: 10.3390/jcm7100342
Yan, Jun, Winterford, Clay M., Catts, Vibeke S., Pat, Betty K., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2018). Increased constitutive activation of NF-κB p65 (RelA) in peripheral blood cells of patients with progressive multiple sclerosis. Journal of Neuroimmunology, 320, 111-116. doi: 10.1016/j.jneuroim.2018.04.002
Leibowitz, Saskia M. and Yan, Jun (2016). NF-kappa B pathways in the pathogenesis of multiple sclerosis and the therapeutic implications. Frontiers in Molecular Neuroscience, 9 (84) 84, 84. doi: 10.3389/fnmol.2016.00084
Yan, J., Greer, J. M. and McCombe, P. A. (2016). Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome. Journal of Neuroimmunology, 293, 22-27. doi: 10.1016/j.jneuroim.2016.02.001
Chan, Adeline, Yan, Jun, Csurhes, Peter, Greer, Judith and McCombe, Pamela (2015). Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: effect on outcome. Journal of Neuroimmunology, 286, 42-47. doi: 10.1016/j.jneuroim.2015.06.013
Yan, Jun, Liu, Jia, Greer, Judith M. and McCombe, Pamela A. (2014). Increased expression of the hypoxia-related genes in peripheral blood leukocytes of human subjects with acute ischemic stroke. Clinical and Experimental Neuroimmunology, 5 (2), 216-226. doi: 10.1111/cen3.12104
Liu, Jia, Yan, Jun, Greer, Judith M., Read, Stephen J., Henderson, Robert D., Rose, Stephen E., Coulthard, Alan and McCombe, Pamela A. (2014). Correlation of adrenomedullin gene expression in peripheral blood leukocytes with severity of ischemic stroke. International Journal of Neuroscience, 124 (4), 271-280. doi: 10.3109/00207454.2013.837462
Yan, Jun, Catts, Vibeke S., Chan, Anthony and McCombe, Pamela A. (2013). A simple and reliable immunohistochemical method for colocalization of 2 antigens in the same cells of paraffin-embedded tissues. Applied Immunohistochemistry and Molecular Morphol, 21 (5), 471-477. doi: 10.1097/PAI.0b013e3182795710
Yan, Jun, Lin, Clement Y. H., Pfluger, Casey M. and McCombe, Pamela A. (2013). Levels of interleukin 33 and soluble suppression of tumorigenicity 2 in acute ischemic stroke. Clinical and Experimental Neuroimmunology, 4 (3), 339-347. doi: 10.1111/cen3.12067
Yan, Jun, Greer, Judith M. and McCombe, Pamela A. (2012). Prolonged elevation of cytokine levels after human acute ischaemic stroke with evidence of individual variability. Journal of Neuroimmunology, 246 (1-2), 78-84. doi: 10.1016/j.jneuroim.2012.02.013
Yan, Jun, Read, Stephen J., Henderson, Robert D., Hull, Renee, O'Sullivan, John D., McCombe, Pamela A. and Greer, Judith M. (2012). Frequency and function of regulatory T cells after ischaemic stroke in humans. Journal of Neuroimmunology, 243 (1-2), 89-94. doi: 10.1016/j.jneuroim.2011.12.019
Yan, Jun, Liu, Jia, Lin, Clement Yihao, Australia and New Zealand Multiple Sclerorsis Genetics Consortium, Csurhes, Peter A., Pender, Michael P., McCombe, Pamela A. and Greer, Judith M. (2012). Interleukin-6 Gene Promoter-572 C Allele may play a role in rate of disease progression in Multiple Sclerosis. International Journal of Molecular Sciences, 13 (10), 13667-13679. doi: 10.3390/ijms131013667
Singh, P., Yan, J., Hull, R., Read, S., O'Sullivan, J., Henderson, R.D., Rose, S., Greer, J.M. and McCombe, P.A. (2011). Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke. Journal of the Neurological Sciences, 304 (1-2), 117-121. doi: 10.1016/j.jns.2011.01.025
Yan, Jun, Greer, Judith M., Hull, Renee, O'Sullivan, John D., Henderson, Robert D., Read, Stephen J. and McCombe, Pamela A. (2010). The effect of ageing on human lymphocyte subsets: comparison of males and females. Immunity & Ageing, 7 (4) 1742, 1-10. doi: 10.1186/1742-4933-7-4
Yan, Jun, Greer, Judith M., Etherington, Kellie, Cadigan, Greg P., Cavanagh, Helen, Henderson, Robert D., O'Sullivan, John D., Pandian, Jeyaraj D., Read, Stephen J. and McCombe, Pamela A. (2009). Immune activation in the peripheral blood of patients with acute ischemic stroke. Journal of Neuroimmunology, 206 (1-2), 112-117. doi: 10.1016/j.jneuroim.2008.11.001
Yan, J. and Greer, Judith M. (2008). NF-kB, a potential therapeutic target for the treatment of multiple sclerosis. CNS & Neurological Disorders - Drug Targets, 7 (6), 536-557. doi: 10.2174/187152708787122941
Jaumot, M., Yan, J., Clyde-Smith, J., Sluimer, J. and Hancock, J. F. (2002). The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. Journal of Biological Chemistry, 277 (1), 272-278. doi: 10.1074/jbc.M108423200
Prior, Ian A., Harding, Angus, Yan, Jun, Sluimer, Judith, Parton, Robert G. and Hancock, John F. (2001). GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nature Cell Biology, 3 (4), 368-375. doi: 10.1038/35070050
Yan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035.
Yan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. doi: 10.1080/09553000050111497
Zhang, X., Yan, J., Cuttle, L., Endre, Z. H. and Gobe, G. C. (2000). Escape from apoptosis after prolonged serum deprivation is associated with the regulation of the mitochondrial death pathway by Bcl-xL. Biochemical & Biophysical Research Communications, 277 (2), 487-493. doi: 10.1006/bbrc.2000.3699
Degnan, Bernard M., Yan, Jun and Lavin, Martin F. (1998). Evidence of multiple transcription initiation and termination sites within the rDNA intergenic spacer and rRNA readthrough transcription in the urochordate Herdmania curvata. Molecular Marine Biology And Biotechnology, 7 (4), 294-302.
Yan, J, Roy, S, Apolloni, A, Lane, A and Hancock, JF (1998). Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. Journal of Biological Chemistry, 273 (37), 24052-24056. doi: 10.1074/jbc.273.37.24052
Roy, S., McPherson, R. A., Apolloni, A., Yan, J., Lane, A., Clyde-Smith, J. and Hancock, J. F. (1998). 14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo. Molecular and Cellular Biology, 18 (7), 3947-3955. doi: 10.1128/MCB.18.7.3947
Roy, S, Lane, A, Yan, J, McPherson, R and Hancock, JF (1997). Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger. Journal of Biological Chemistry, 272 (32), 20139-20145. doi: 10.1074/jbc.272.32.20139
Khanna, KK, Yan, J, Watters, D, Hobson, K, Beamish, H, Spring, K, Shiloh, Y, Gatti, RA and Lavin, MF (1997). Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells. Journal of Biological Chemistry, 272 (14), 9489-9495. doi: 10.1074/jbc.272.14.9489
Yan, J, Khanna, KK and Lavin, MF (1996). Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation. International Journal of Radiation Biology, 69 (5), 539-546. doi: 10.1080/095530096145544
Khanna, KK, Beamish, H, Yan, J, Hobson, K, Williams, R, Dunn, I and Lavin, MF (1995). Nature of G1/s cell-cycle checkpoint defect in ataxia-telangiectasia. Oncogene, 11 (4), 609-618.
Degnan, B. M., Yan, J., Hawkins, C. J. and Lavin, M. F. (1990). rRNA genes from the lower chordate Herdmania momus; structural similarity with higher eukaryotes.. Nucleic Acids Research, 18 (23), 7063-7070. doi: 10.1093/nar/18.23.7063
Qi, ZH, Yan, J and Zhu, QL (1989). Studies On the Structure of Hbv Dna. Science in China Series B-Chemistry, 32 (11), 1318-1328.
Conference Papers
Cloake, Nancy, Yan, Jun, Pender, Michael, Aminian, Atefeh and Greer, Judith (2014). PLP1 mutations in patients with multiple sclerosis: Identification of a new mutation and analysis of in vitro effects of PLP1 mutations. 12th International Congress of Neuroimmunology (ISNI), Mainz Germany, 9-13 November 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jneuroim.2014.08.268
Yan, Jun, Greer, Judith, Mccombe, Pamela, Pender, Michael and Consortium, Anzgene (2014). Characterization of genetic variants in the NFKBIA promoter region in multiple sclerosis. 12th International Congress of Neuroimmunology (ISNI), Mainz, Germany, Nov 09-13, 2014. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.jneuroim.2014.08.141
Yan, J., Pender, M.P., Liu, J., McCombe, P.A., Greer, J.M. and ANZgene Consortium (2012). Investigation of gene mutations in the NFKBIA promoter region in patients with multiple sclerosis. Progress in MS Research Conference 2011, Melbourne, VIC, Australia, 26-28 October 2011. London, United Kingdom: Sage Publications.
McCombe, Pamela, Liu, Jia, Yan, Jun and Greer, Judith (2012). Increased expression of the hypoxia related genes in peripheral blood cells of subjects with acute ischaemic stroke. 11th International Congress of Neuroimmunology (ISNI), Boston MA., United States, 4-8 November 2012. Amsterdam, The Netherlands: Elsevier.
Badve, Monica S., Yan, J., Hull, R., Henderson, Robert, O’Sullivan, John D., Read, Stephen J., Wong, Andrew A. and McCombe, Pamela (2010). Immune response in acute ischaemic stroke. ANZAN Annual Scientific Meeting 2010, -, 2010. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jocn.2010.07.064
Yan, J., Greer, J. M., Cavanagh, H., Henderson, R., O'Sullivan, J., Read, S., Etherington, K. and McCombe, P. A. (2007). Increased population of activated T cells in patients after acute ischemic stroke. 37th Annual Scientific Meeting of the Australasian Society for Immunology, Sydney, Australia, 2-6 December 2007.
Yan, J., Pat, B., Winterford, C., Inglis, H. R., Pender, M. P. and Greer, J. M. (2005). Levels of constitutively activated NF-kB are increased and IB levels are decreased in T cells and macrophages from patients with multiple sclerosis. 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, 29 November - 2 December 2005. Copenhagen, Denmark: Munksgaard. doi: 10.1111/j.1399-0039.2005.00523.x
Gobe, G., Li, J., Pat, B., Yan, J., Vesey, D., Johnson, D. and Nicol, D. (2005). Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas. 41th [sic] Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, 4-8 September 2005, Carlton, Victoria. Blackwell Science: 1320-5358 (print); 1440-1797 (electronic). doi: 10.1111/j.1440-1797.2005.00461.x
Yan, J., Pat, B., Winterford, C., Inglis, F., Pender, M. P. and Greer, J. M. (2005). Increased constitutive activation of NF-kappa B in patients with multiple sclerosis. 5th Annual Meeting of the Federation of Clinical Immunology Society, Boston, MA, United States, 12-16 May 2005. SAN DIEGO: Academic Press.
Li, J., Pat, B., Yan, J., Vesey, D. A., Johnson, D. W., Nicol, D. and Gobe, G. C. (2003). Role of PKC-a and -e in cytotoxic chemotherapy of renal cell carcinomas. 39th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Perth, WA, Australia, 31 August- 3 September, 2003. Carlton South, Australia: Blackwell Publishing Asia. doi: 10.1046/j.1440-1797.8.s3.1.x
Yan, J., Inglis, H., Pender, M. P. and Greer, J. M. (2002). Comparison of NF-kB in immune cells of multiple sclerosis patients and controls Society for Cytokines, Inflammation and Leukocytes. 32nd Annual Scientific Meeting of the ASI, Brisbane, Qld, Australia, 8-12 December, 2002.
Yan, J., Rist, M. J., Dodson, M. J., Pender, M. P. and Greer, J. M. (2002). Comparison of regulatory cell populations in patients with multiple sclerosis and controls. Progress in MS Research, Sydney, 9-11 Oct, 2002.