Book Chapter
Lavin, Martin F., Gatei, Magtouf, Chen, Philip, Kijas, Amanda and Kozlov, Sergei (2010). ATM mediated signaling defends the integrity of the genome. Handbook of Cell Signaling. (pp. 2171-2183) edited by Ralph A. Bradshaw and Edward A. Dennis. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-374145-5.00263-1
Journal Articles
Lynch, Matthew, Manoy, Sophie, Sly, Peter D., Wainwright, Claire E., Wolvetang, Ernst, Feenstra, John E., Dowling, Jason, Ware, Robert S., Patel, Maharshi S., Hermith-Ramirez, Diana, Vogel, Adam, Preece, Kahn, Zappala, Tania, Dai, Shuan, Webber, Ann, Yeo, Abrey, Subramanian, Goutham, Rao, Geetha, Ma, Cindy S., Jose, Sara, Gatei, Magtouf, Xin, Bowen, Sandona, Nicoletta, Lewindon, Peter, Sinclair, Katherine G., Nayler, Sam, Lavin, Martin F. and Coman, David J. (2025). Phase 2a/b randomised placebo-controlled dose-escalation trial of triheptanoin for ataxia-telangiectasia: treating mitochondrial dysfunction with anaplerosis. eBioMedicine, 118 105840, 1-17. doi: 10.1016/j.ebiom.2025.105840
Subramanian, Goutham Narayanan, Yeo, Abrey Jie, Gatei, Magtouf Hnaidi, Coman, David John and Lavin, Martin Francis (2022). Metabolic stress and mitochondrial dysfunction in ataxia-telangiectasia. Antioxidants, 11 (4) 653, 653. doi: 10.3390/antiox11040653
Yeo, A.J., Subramanian, G.N., Chong, K.L., Gatei, M., Parton, R.G., Coman, D. and Lavin, M.F. (2021). An anaplerotic approach to correct the mitochondrial dysfunction in ataxia-telangiectasia (A-T). Molecular Metabolism, 54 101354, 101354. doi: 10.1016/j.molmet.2021.101354
Yeo, Abrey J., Kok, Chong L., Gatei, Magtouf, Zou, Dongxiu, Stewart, Romal, Withey, Sarah, Wolvetang, Ernst, Parton, Robert G., Brown, Adam D., Kastan, Michael B., Coman, David and Lavin, Martin F. (2021). Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia. iScience, 24 (1) 101972, 101972. doi: 10.1016/j.isci.2020.101972
Samadani, Ali Akbar, Norollahi, Syedeh Elham, Rashidy-Pour, Ali, Mansour-Ghanaei, Fariborz, Nemati, Shadman, Joukar, Farahnaz, Afshar, Amir Mahmoud, Ghazanfari, Sahar, Safizadeh, Mahsa, Rostami, Pooya and Gatei, Magtouf (2018). Cancer signaling pathways with a therapeutic approach: An overview in epigenetic regulations of cancer stem cells. Biomedicine and Pharmacotherapy, 108, 590-599. doi: 10.1016/j.biopha.2018.09.048
Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 (4), 927-947. doi: 10.1189/jlb.4VMA0716-316R
Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016). A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Human Molecular Genetics, 26 (1), 109-123. doi: 10.1093/hmg/ddw371
Lavin, Martin F., Kozlov, Sergei, Gatei, Magtouf and Kijas, Amanda W. (2015). ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules, 5 (4) A31, 2877-2902. doi: 10.3390/biom5042877
Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754
Gatei, Magtouf, Kijas, Amanda W., Biard, Denis, Dork, Thilo and Lavin, Martin F. (2014). RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress. Human Molecular Genetics, 23 (16) ddu141, 4232-4248. doi: 10.1093/hmg/ddu141
Puccini, Joseph, Shalini, Sonia, Voss, Anne K., Gatei, Magtouf, Wilson, Claire H., Hiwase, Devendra K., Lavin, Martin F., Dorstyn, Loretta and Kumar, Sharad (2013). Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 110 (49), 19920-19925. doi: 10.1073/pnas.1311947110
Stewart, Romal, Kozlov, Sergei, Matigian, Nicholas, Wali, Gautam, Gatei, Magtouf, Sutharsan, Ratneswary, Bellette, Bernadette, Kijas, Amanda Wraith, Cochrane, Julie, Coulthard, Mark, Perry, Chris, Sinclair, Kate, Mackay-Sim, Alan and Lavin, Martin F. (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22 (12), 2495-2509. doi: 10.1093/hmg/ddt101
Nayler, Sam, Gatei, Magtouf, Kozlov, Sergei, Gatti, Richard, Mar, Jessica C., Wells, Christine A., Lavin, Martin and Wolvetang, Ernst (2012). Induced Pluripotent Stem Cells from Ataxia-Telangiectasia Recapitulate the Cellular Phenotype. Stem Cells Translational Medicine, 1 (7), 523-535. doi: 10.5966/sctm.2012-0024
Gatei, Magtouf, Jakob, Burkhard, Chen, Philip, Kijas, Amanda W., Becherel, Olivier J., Gueven, Nuri, Birrell, Geoff, Lee, Ji-Hoon, Paull, Tanya T., Lerenthal, Yaniv, Fazry, Shazrul, Taucher-Scholtz, Gisela, Kalb, Reinhard, Schindler, Detlev, Waltes, Regina, Doerk, Thilo and Lavin, Martin F. (2011). ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. Journal of Biological Chemistry, 286 (36), 31542-31556. doi: 10.1074/jbc.M111.258152
Waltes, R., Kalb, R., Gatei, M., Kijas, A.W., Stumm, M., Sobeck, A., Wieland, B., Varon, R., Lerenthal, Y., Lavin, M. F., Schindler, D. and Dörk, T. (2009). Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.. American Journal of Human Genetics, 84 (5), 605-616. doi: 10.1016/j.ajhg.2009.04.010
Suraweera, A., Becherel, O. J., Chen, P., Rundle, N., Woods, R., Nakamura, J., Gatei, M., Criscuolo, C., Filla, A., Chessa, L., Fusser, M., Epe, B., Gueven, N. and Lavin, M. F. (2007). Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. Journal of Cell Biology, 177 (6), 969-979. doi: 10.1083/jcb.200701042
Pylkas, K., Tommiska, J., Syrjakoski, K., Kere, J., Gatei, M., Waddell, N., Allinen, M., Karppinen, SM., Rapakko, K., Kaariainen, H., Aittomaki, K., Blomqvist, C., Mustonen, A., Holli, K., Khanna, K.K., Kallioniemi, O.P., Nevanlinna, H. and Winqvist, R. (2007). Evaluation of the role of Finnish ataxia-telangiectasia mutations in hereditary predisposition to breast cancer. Carcinogenesis, 28 (5), 1040-1045. doi: 10.1093/carcin/bgl237
Khanna, Kum Kum, Gatei, Magtouf and Tribbick, Gordon (2006). Phospho-specific antibodies as a tool to study in vivo regulation of BRCA1 after DNA damage. Methods in Molecular Medicine, 120, 441-452. doi: 10.1385/1-59259-969-9:441
Young, David B., Jonnalagadda, Jyoti, Gatei, Magtouf, Jans, David A., Meyn, Stephen and Khanna, Kum Kum (2005). Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. The Journal of Biological Chemistry, 280 (30), 27587-27594. doi: 10.1074/jbc.M411689200
Jekimovs, C. R., Chen, X., Arnold, J., Gatei, M., Richardson, D. J., kConFab Investigators, Spurdle, A. B., Khanna, K. K. and Chenevix-Trench, G. (2005). Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. British Journal Of Cancer, 92 (4), 784-790. doi: 10.1038/sj.bjc.6602381
Gatei, Magtouf, Sloper, Katie, Sorensen, Claus, Syljuasen, Randi, Falck, Jacob, Hobson, Karen, Savage, Kienan, Lukas, Jiri, Zhou, Bin-Bing, Bartek, Jiri and Khanna, Kum Kum (2003). Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278 (17), 14806-14811. doi: 10.1074/jbc.M210862200
Chenevix-Trench, Georgia, Spurdle, Amanda B., Gatei, Magtouf, Kelly, Helena, Marsh, Anna, Chen, Xiaoqing, Donn, Karen, Cummings, Margaret C., Nyholt, Dale, Jenkins, Mark A., Scott, Clare, Pupo, Gulietta M., Dork, Thilo, Bendix, Regina, Kirk, Judy, Tucker, Katherine, McCredie, Margaret R. E., Hopper, John L., Sambrook, Joseph, Mann, Graham J. and Khanna, Kum Kum (2002). Dominant negative ATM mutations in breast cancer families. Journal of the National Cancer Institute, 94 (3), 205-215. doi: 10.1093/jnci/94.3.205
Gatei, Magtouf, Zhou, Bin-Bing, Hobson, Karen, Scott, Shaun, Young, David and Khanna, Kum Kum (2001). Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 (20), 17276-17280. doi: 10.1074/jbc.M011681200
Gatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F. and Rotman, G. (2001). Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 (3), 289-294. doi: 10.1038/sj.onc.1204111
Fillippovich, I., Sorokina, N., Gatei, M., Haupt, Y., Hobson, K., Moallem, E., Spring, K., Mould, M., McGuckin, M. A., Lavin, M. F. and Khanna, K. K. (2001). Transactivation-deficient p73 alpha (p73 Delta exon2) inhibits apoptosis and competes with p53. Oncogene, 20 (4), 514-522. doi: 10.1038/sj.onc.1204118
Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 (1), 115-119. doi: 10.1038/75508
Gatei, M., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. and Khanna, K. (2000). Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Research, 60 (12), 3299-3304.
Fukao, Toshiyuki, Kaneko, Hideo, Birrell, Geoff, Gatei, Magtouf, Tashita, Hideaki, Yoshida, Toko, Cross, Simone, Kedar, Padmini, Watters, Dianne, Khanna, Kum Kum, Misko, Ihor, Kondo, Naomi and Lavin, Martin F. (1999). ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells. Blood, 94 (6), 1998-2006. doi: 10.1182/blood.v94.6.1998.418k01_1998_2006
Liao, Wen-Chieh, Haimovitz-Friedman, Adriana, Persaud, Roger S., McLoughlin, Maureen, Ehleiter, Desiree, Zhang, Ning, Gatei, Magtouf, Lavin, Martin, Kolesnick, Richard and Fuks, Zvi (1999). Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. Journal of Biological Chemistry, 274 (25), 17908-17917. doi: 10.1074/jbc.274.25.17908
Chen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K. and Lavin, M. F. (1999). CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia. Oncogene, 18 (1), 249-256. doi: 10.1038/sj.onc.1202257
Watters, D., Kedar, P., Spring, K., Bjorkman, J., Chen, P., Gatei, M., Birrell, G., Garrone, B., Sirinivasa, P., Crane, D. I. and Lavin, M. F. (1999). Localisation of a portion of extranuclear ATM to peroxisomes. Journal of Biological Chemistry, 274 (48), 34277-34282. doi: 10.1074/jbc.274.48.34277
Zhang, Ning, Chen, Phil, Gatei, Magtouf, Scott, Shaun, Khanna, Kum Kum and Lavin, Martin F. (1998). An anti-sense construct of full-length ATM cDNA imposes a radiosensitive phenotype on normal cells. Oncogene, 17 (7), 811-818. doi: 10.1038/sj.onc.1202007
Shafman, T, Khanna, KK, Kedar, P, Spring, K, Kozlov, S, Yen, T, Hobson, K, Gatei, M, Zhang, N, Watters, D, Egerton, M, Shiloh, Y, Kharbanda, S, Kufe, D and Lavin, MF (1997). Interaction between ATM protein and c-Abl in response to DNA damage. Nature, 387 (6632), 520-523. doi: 10.1038/387520a0
Watters, D, Khanna, KK, Beamish, H, Birrell, G, Spring, K, Kedar, P, Gatei, M, Stenzel, D, Hobson, K, Kozlov, S, Zhang, N, Farrell, A, Ramsay, J, Gatti, R and Lavin, M (1997). Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene, 14 (16), 1911-1921. doi: 10.1038/sj.onc.1201037
Zhang, N., Chen, P., Khanna, K.K., Scott, S., Gatei, M., Kozlov, S., Watters, D., Spring, K., Yen, T. and Lavin, M.F. (1997). Isolation of full-length ATM cDNA and correction of the ataxia- telangiectasia cellular phenotype. Proceedings of the National Academy of Sciences of the United States of America, 94 (15), 8021-8026. doi: 10.1073/pnas.94.15.8021
Chen, P., Girjes, A. A., Hobson, K., Beamish, H., Khanna, K. K., Farrell, A., Gatei, M., Teale, B., Buchwald, M., Legerski, R. and Lavin, M. F. (1996). Genetic complementation of radiation response by 3′ untranslated regions (UTR) of RNA. International Journal of Radiation Biology, 69 (3), 385-395. doi: 10.1080/095530096145940
Daniel, R.C.W., Gatei, M.H., Good, M.F., Boyle, D.B. and Lavin, M.F. (1993). Recombinant viral vaccines for enzootic bovine leucosis. Immunology and Cell Biology, 71 (5), 399-404. doi: 10.1038/icb.1993.46
Gatei, M. H., Naif, H. M., Kumar, S., Boyle, D. B., Daniel, R. C.W., Good, M. F. and Lavin, M. F. (1993). Protection of sheep against bovine leukemia virus (BLV) infection by vaccination with recombinant vaccinia viruses expressing BLV envelope glycoproteins: Correlation of protection with CD4 T-cell response to gp51 peptide 51-70. Journal of Virology, 67 (4), 1803-1810. doi: 10.1128/jvi.67.4.1803-1810.1993
Gatei, M. H., Good, M. F., Daniel, R. C.W. and Lavin, M. F. (1993). T-cell responses to highly conserved CD4 and CD8 epitopes on the outer membrane protein of bovine leukemia virus: Relevance to vaccine development. Journal of Virology, 67 (4), 1796-1802. doi: 10.1128/jvi.67.4.1796-1802.1993
Gatei, M.H., Chen, P.M., Daniel, R.C. and Lavin, M.F. (1991). DNA fingerprints of sheep using an M13 probe. Animal Genetics, 22 (3), 285-289. doi: 10.1111/j.1365-2052.1991.tb00678.x
Gatei, M. H., Lavin, M. F. and Daniel, R. C.W. (1990). Serum Immunoglobulin Concentrations in Cattle Naturally Infected with Bovine Leukemia Virus. Journal of Veterinary Medicine, Series B, 37 (1-10), 575-580. doi: 10.1111/j.1439-0450.1990.tb01099.x
Gatei, M. H., Brandon, R. B., Naif, H. M., McLennan, M. W., Daniel, R. C.W. and Lavin, M. F. (1989). Changes in B cell and T cell subsets in bovine leukaemia virus-infected cattle. Veterinary Immunology and Immunopathology, 23 (1-2), 139-147. doi: 10.1016/0165-2427(89)90116-5
Brandon, R. B., Gatei, M. H., Naif, H. M., Daniel, R. C.W. and Lavin, M. F. (1989). Observations on blood leucocytes and lymphocyte subsets in sheep infected with bovine leukaemia virus: A progressive study. Veterinary Immunology and Immunopathology, 23 (1-2), 15-27. doi: 10.1016/0165-2427(89)90106-2
Gatei, M. H., Brandon, R., Naif, H. M., Lavin, M. F. and Daniel, R. C.W. (1989). Lymphosarcoma Development in Sheep Experimentally Infected with Bovine Leukaemia Virus. Journal of Veterinary Medicine, Series B, 36 (1-10), 424-432. doi: 10.1111/j.1439-0450.1989.tb00624.x
Gatei, M. H., McLennan, M. W., Lavin, M. F. and Daniel, R. C.W. (1989). Experimental Infection of Sheep with Bovine Leukemia Virus: Infectivity of Blood, Nasal and Saliva Secretions. Journal of Veterinary Medicine, Series B, 36 (1-10), 652-660. doi: 10.1111/j.1439-0450.1989.tb00658.x
Conference Papers
Quek, H., Luff, J., Cheung, K., Kozlov, S., Gatei, M., Lee, C. S., Bellingham, M., Noakes, P., Lim, Y. C., Barnett, N., Dingwall, S., Wolvetang, E., Mashimo, T., Roberts, T. and Lavin, M. (2016). Neuroinflammation drives the neuronal degenerative phenotype in a rat model of Ataxia-telangiectasia. International Congress of Immunology (ICI), Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley. doi: 10.1002/eji.201670200
Lavin, M.F., Khanna, K.K., Watters, D., Spring, K., Scott, S., Keating, K., Gatei, M., Kaneko, H. and Kozlov, S. (2000). Sensing damage in DNA: ATM and cellular signalling. 11th International Congress of Radiation Research, Dublin, Ireland, 18-23 July 1999. Lawrence, KS United States: Allen Press.
Watters, D., Srinivasa, P., Spring, K., Kedar, P., Bjorkman, J., Chen, P., Gatei, M., Crane, D. and Lavin, M. F. (1999). ATM in peroxisomes: A role in ionizing radiation response and oxidative stress?. 11th Lorne Cancer Conference, Melbourne, VIC Australia, 11-14 February 1999. Melbourne, VIC Australia: Australian Cancer Society.
Watters, D., Spring, K., Chen, P., Kedar, P., Gatei, M., Bjorkman, J., Crane, D. and Lavin, M. F. (1999). ATM is present in peroxisomes. Australian Society for Biochemistry & Molecular Biology Combio 99, Gold Coast, QLD Australia, 26-30 September 1999. Brisbane, QLD Australia: Australian Society of Biochemistry.
Thesis
Gatei, Magtouf Hnaidi (1993). Some aspects of the pathogenicity and immunity of bovine leukemia virus infection in cattle and sheep. PhD Thesis, School of Veterinary Science, The University of Queensland. doi: 10.14264/ec8817a