Yu Group - Systems and translational immunology

About

The immune system strikes a kaleidoscope way to eliminate different types of infections and cancerous cells. While immune deficiency leads to susceptibility to infections and cancer, the trade-off of “strong” immune responses is the risk of autoimmune diseases and inflammation. The maintenance of a competent but balanced immune system is the cornerstone of health. The sophisticated immune defence mechanisms are essentially orchestrated by T cells. Not only can T cells directly kill infected and cancerous cells, but they also, through multiple subsets, fundamentally control the activation and function of other immune cell types.

In the lab of Systems and Translational Immunology Laboratory (STIL), Professor Di Yu and his team are investigating the molecular mechanisms and the landscape by which T cells control the competence and balance of the immune system, intending to design new strategies to modulate the immune system and to treat autoimmune and allergic diseases, infection and cancer. Our research ranges from those at the molecular level to animal disease models and human clinical trials, with the integration of the data-driven systems immunology approach.

Our basic and translational research has been published in high impact journals including Nature, Nature Immunology, Nature Medicine and Immunity.  Professor Di Yu is a world Highly Cited Researcher (HCR).