Frazer Institute Summer Research projects - 2027
4. Stem cell therapy effects on mitochondrial dysfunction in the fetal growth restricted piglet brain
Hours of engagement and delivery mode | The project will be conducted over 6 weeks. Students will generally work across 4 days per week between 20-24h, with flexibility around the timing of laboratory activities. |
Project description | Fetal growth restriction (FGR) is a condition in which the fetus fails to grow properly during pregnancy, which is linked to neurodevelopmental impairments. Previous work in our lab has shown that FGR piglets show signs of mitochondrial dysfunction, suggesting problems in how brain cells produce energy. What remains unknown is which specific cell types are most affected and how this contributes to neuropathology. In this project, the student will use immunofluorescence to identify which brain cells show disrupted mitochondrial function by comparing brain tissue from normally grown and FGR piglets. In addition, an FGR stem cell treated group will be studied to determine whether stem cell therapy can restore mitochondrial health in vulnerable cell types. This work will contribute to understanding how adverse fetal conditions shape long-term brain health and support the development of therapeutic strategies. |
Expected outcomes and deliverables | Students will work with prepared brain tissue and learn how to identify relevant brain regions. They will perform immunofluorescence to label specific brain cell types alongside markers associated with mitochondrial dysfunction. |
Suitable for | This project is well suited to students from any biological discipline with an interest in brain research and early neurodevelopment. It is especially valuable for those considering a future research career, providing direct experience with data generation, and scientific communication. |
Primary supervisor | Dr Julie Wixey |
Instructions to applicants | Students may contact the supervisor before applying |